Evolutionary Analysis of the Lysine-Rich N-terminal Cytoplasmic Domains of the Gastric H+,K+-ATPase and the Na+,K+-ATPase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Dil Diaz, Ronald J. Clarke

ABSTRACT

The catalytic α-subunits of both the Na+,K+-ATPase and the gastric H+,K+-ATPase possess lysine-rich N-termini which project into the cytoplasm. Due to conflicting experimental results, it is currently unclear whether the N-termini play a role in ion pump function or regulation, and, if they do, by what mechanism. Comparison of the lysine frequencies of the N-termini of both proteins with those of all of their extramembrane domains showed that the N-terminal lysine frequencies are far higher than one would expect simply from exposure to the aqueous solvent. The lysine frequency was found to vary significantly between different vertebrate classes, but this is due predominantly to a change in N-terminal length. As evidenced by a comparison between fish and mammals, an evolutionary trend towards an increase of the length of the N-terminus of the H+,K+-ATPase on going from an ancestral fish to mammals could be identified. This evolutionary trend supports the hypothesis that the N-terminus is important in ion pump function or regulation. In placental mammals, one of the lysines is replaced by serine (Ser-27), which is a target for protein kinase C. In most other animal species, a lysine occupies this position and hence no protein kinase C target is present. Interaction with protein kinase C is thus not the primary role of the lysine-rich N-terminus. The disordered structure of the N-terminus may, via increased flexibility, facilitate interaction with another binding partner, e.g. the surrounding membrane, or help to stabilise particular enzyme conformations via the increased entropy it produces. More... »

PAGES

1-14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00232-018-0043-x

DOI

http://dx.doi.org/10.1007/s00232-018-0043-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105895259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30056551


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "School of Chemistry, University of Sydney, 2006, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diaz", 
        "givenName": "Dil", 
        "id": "sg:person.013360612424.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013360612424.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "School of Chemistry, University of Sydney, 2006, Sydney, NSW, Australia", 
            "The University of Sydney Nano Institute, 2006, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clarke", 
        "givenName": "Ronald J.", 
        "id": "sg:person.01233617533.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233617533.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1982.tb25743.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000701839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.17.9132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001893443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1999.3110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002979516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003600050224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005638447", 
          "https://doi.org/10.1007/s003600050224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00513.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005776139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1996.1589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007739847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3233(02)62004-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008887485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1243352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009080707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1243352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009080707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-440x(02)00289-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011350804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00006286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011413241", 
          "https://doi.org/10.1007/pl00006286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btn195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012413956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msw054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012564990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m705899200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016730890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sbi.2012.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020775760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023657224", 
          "https://doi.org/10.1038/nature12578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/polym6102684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025055021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025846396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026130589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028033266", 
          "https://doi.org/10.1038/nrm3031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028033266", 
          "https://doi.org/10.1038/nrm3031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m206115200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028879176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(03)74977-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029864896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.39.23683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032132370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-1-4832-2734-4.50017-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032138540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032306700", 
          "https://doi.org/10.1038/nature07939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032306700", 
          "https://doi.org/10.1038/nature07939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0134116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032907579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(75)90239-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033969747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(75)90239-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033969747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.24105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037273117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2170/jjphysiol.50.419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038386284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(86)90555-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038552288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(86)90555-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038552288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-890-0:571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038854297", 
          "https://doi.org/10.1385/1-59259-890-0:571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.71.102201.141218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043362040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01870942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046010638", 
          "https://doi.org/10.1007/bf01870942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01870942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046010638", 
          "https://doi.org/10.1007/bf01870942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046382388", 
          "https://doi.org/10.1038/nature06419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-008-0495-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046856644", 
          "https://doi.org/10.1007/s00424-008-0495-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-008-0495-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046856644", 
          "https://doi.org/10.1007/s00424-008-0495-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00232-002-1041-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047083627", 
          "https://doi.org/10.1007/s00232-002-1041-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.23.14072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048279425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.24065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050419334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340040204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052424463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340040204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052424463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(88)80033-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053213988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2017.01.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053877231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi0504456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055200341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi0504456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055200341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.4.1.1353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2016.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074212150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077197870", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.molbev.a040454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079752303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082569397", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1558-5646.1985.tb00420.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085717760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2018.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101358304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0003-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101862103", 
          "https://doi.org/10.1038/s41586-018-0003-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0003-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101862103", 
          "https://doi.org/10.1038/s41586-018-0003-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2018.04.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104993852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2018.04.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104993852"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "The catalytic \u03b1-subunits of both the Na+,K+-ATPase and the gastric H+,K+-ATPase possess lysine-rich N-termini which project into the cytoplasm. Due to conflicting experimental results, it is currently unclear whether the N-termini play a role in ion pump function or regulation, and, if they do, by what mechanism. Comparison of the lysine frequencies of the N-termini of both proteins with those of all of their extramembrane domains showed that the N-terminal lysine frequencies are far higher than one would expect simply from exposure to the aqueous solvent. The lysine frequency was found to vary significantly between different vertebrate classes, but this is due predominantly to a change in N-terminal length. As evidenced by a comparison between fish and mammals, an evolutionary trend towards an increase of the length of the N-terminus of the H+,K+-ATPase on going from an ancestral fish to mammals could be identified. This evolutionary trend supports the hypothesis that the N-terminus is important in ion pump function or regulation. In placental mammals, one of the lysines is replaced by serine (Ser-27), which is a target for protein kinase C. In most other animal species, a lysine occupies this position and hence no protein kinase C target is present. Interaction with protein kinase C is thus not the primary role of the lysine-rich N-terminus. The disordered structure of the N-terminus may, via increased flexibility, facilitate interaction with another binding partner, e.g. the surrounding membrane, or help to stabilise particular enzyme conformations via the increased entropy it produces.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00232-018-0043-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5127721", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6712166", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1012006", 
        "issn": [
          "0022-2631", 
          "1432-1424"
        ], 
        "name": "The Journal of Membrane Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5-6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "251"
      }
    ], 
    "name": "Evolutionary Analysis of the Lysine-Rich N-terminal Cytoplasmic Domains of the Gastric H+,K+-ATPase and the Na+,K+-ATPase", 
    "pagination": "1-14", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "295a6ae9a44e3af14706c9cbe380e8de079b0eadb0c821fe44437b67b0f7827c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30056551"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0211301"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00232-018-0043-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105895259"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00232-018-0043-x", 
      "https://app.dimensions.ai/details/publication/pub.1105895259"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000609.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00232-018-0043-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00232-018-0043-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00232-018-0043-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00232-018-0043-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00232-018-0043-x'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00232-018-0043-x schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N0247ab8fcb8a45ceb802ce3082743a9f
4 schema:citation sg:pub.10.1007/bf01870942
5 sg:pub.10.1007/pl00006286
6 sg:pub.10.1007/s00232-002-1041-5
7 sg:pub.10.1007/s003600050224
8 sg:pub.10.1007/s00424-008-0495-4
9 sg:pub.10.1038/nature06419
10 sg:pub.10.1038/nature07939
11 sg:pub.10.1038/nature12578
12 sg:pub.10.1038/nrm3031
13 sg:pub.10.1038/s41586-018-0003-8
14 sg:pub.10.1385/1-59259-890-0:571
15 https://app.dimensions.ai/details/publication/pub.1077197870
16 https://app.dimensions.ai/details/publication/pub.1082569397
17 https://doi.org/10.1002/prot.24065
18 https://doi.org/10.1002/prot.24105
19 https://doi.org/10.1002/prot.340040204
20 https://doi.org/10.1006/bbrc.1996.1589
21 https://doi.org/10.1006/jmbi.1999.3110
22 https://doi.org/10.1016/0005-2736(75)90239-4
23 https://doi.org/10.1016/0005-2736(86)90555-9
24 https://doi.org/10.1016/b978-1-4832-2734-4.50017-6
25 https://doi.org/10.1016/j.bbamem.2017.01.022
26 https://doi.org/10.1016/j.bbamem.2018.03.002
27 https://doi.org/10.1016/j.bpj.2016.12.008
28 https://doi.org/10.1016/j.bpj.2018.04.027
29 https://doi.org/10.1016/j.sbi.2012.11.005
30 https://doi.org/10.1016/s0006-291x(88)80033-0
31 https://doi.org/10.1016/s0006-3495(03)74977-7
32 https://doi.org/10.1016/s0065-3233(02)62004-2
33 https://doi.org/10.1016/s0959-440x(02)00289-0
34 https://doi.org/10.1021/bi0504456
35 https://doi.org/10.1073/pnas.93.17.9132
36 https://doi.org/10.1074/jbc.270.23.14072
37 https://doi.org/10.1074/jbc.271.39.23683
38 https://doi.org/10.1074/jbc.m206115200
39 https://doi.org/10.1074/jbc.m705899200
40 https://doi.org/10.1093/bioinformatics/btn195
41 https://doi.org/10.1093/molbev/msw054
42 https://doi.org/10.1093/nar/gkh253
43 https://doi.org/10.1093/nar/gkh340
44 https://doi.org/10.1093/oxfordjournals.molbev.a040454
45 https://doi.org/10.1111/j.1558-5646.1985.tb00420.x
46 https://doi.org/10.1111/j.1749-6632.1982.tb25743.x
47 https://doi.org/10.1126/science.1243352
48 https://doi.org/10.1146/annurev.biochem.71.102201.141218
49 https://doi.org/10.1152/ajpregu.00513.2003
50 https://doi.org/10.1371/journal.pone.0134116
51 https://doi.org/10.2170/jjphysiol.50.419
52 https://doi.org/10.3390/polym6102684
53 https://doi.org/10.4161/cc.4.1.1353
54 schema:datePublished 2018-12
55 schema:datePublishedReg 2018-12-01
56 schema:description The catalytic α-subunits of both the Na<sup>+</sup>,K<sup>+</sup>-ATPase and the gastric H<sup>+</sup>,K<sup>+</sup>-ATPase possess lysine-rich N-termini which project into the cytoplasm. Due to conflicting experimental results, it is currently unclear whether the N-termini play a role in ion pump function or regulation, and, if they do, by what mechanism. Comparison of the lysine frequencies of the N-termini of both proteins with those of all of their extramembrane domains showed that the N-terminal lysine frequencies are far higher than one would expect simply from exposure to the aqueous solvent. The lysine frequency was found to vary significantly between different vertebrate classes, but this is due predominantly to a change in N-terminal length. As evidenced by a comparison between fish and mammals, an evolutionary trend towards an increase of the length of the N-terminus of the H<sup>+</sup>,K<sup>+</sup>-ATPase on going from an ancestral fish to mammals could be identified. This evolutionary trend supports the hypothesis that the N-terminus is important in ion pump function or regulation. In placental mammals, one of the lysines is replaced by serine (Ser-27), which is a target for protein kinase C. In most other animal species, a lysine occupies this position and hence no protein kinase C target is present. Interaction with protein kinase C is thus not the primary role of the lysine-rich N-terminus. The disordered structure of the N-terminus may, via increased flexibility, facilitate interaction with another binding partner, e.g. the surrounding membrane, or help to stabilise particular enzyme conformations via the increased entropy it produces.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N11ba234a9a104ff88913338a2a156f38
61 Ncfc14c7fa21b428980538938c6aa2b12
62 sg:journal.1012006
63 schema:name Evolutionary Analysis of the Lysine-Rich N-terminal Cytoplasmic Domains of the Gastric H+,K+-ATPase and the Na+,K+-ATPase
64 schema:pagination 1-14
65 schema:productId N665f21d4e0464b80a490fe54f5baee72
66 N701750efb8074f7b9421d5573a863a42
67 N70ceb88ea67f4215aaee134c4bfdd121
68 Nbc4949dfab7042bb85c9eed032327af0
69 Nd43c3bb1edda436bb9e3b8f9aad16495
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105895259
71 https://doi.org/10.1007/s00232-018-0043-x
72 schema:sdDatePublished 2019-04-10T18:33
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Ne8a24ed09a30472aa92a8232948fd5fe
75 schema:url http://link.springer.com/10.1007%2Fs00232-018-0043-x
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0247ab8fcb8a45ceb802ce3082743a9f rdf:first sg:person.013360612424.26
80 rdf:rest Nebb9d0a46ca14dd5903dc51ac845ff9a
81 N11ba234a9a104ff88913338a2a156f38 schema:issueNumber 5-6
82 rdf:type schema:PublicationIssue
83 N665f21d4e0464b80a490fe54f5baee72 schema:name pubmed_id
84 schema:value 30056551
85 rdf:type schema:PropertyValue
86 N701750efb8074f7b9421d5573a863a42 schema:name readcube_id
87 schema:value 295a6ae9a44e3af14706c9cbe380e8de079b0eadb0c821fe44437b67b0f7827c
88 rdf:type schema:PropertyValue
89 N70ceb88ea67f4215aaee134c4bfdd121 schema:name dimensions_id
90 schema:value pub.1105895259
91 rdf:type schema:PropertyValue
92 Nbc4949dfab7042bb85c9eed032327af0 schema:name doi
93 schema:value 10.1007/s00232-018-0043-x
94 rdf:type schema:PropertyValue
95 Ncfc14c7fa21b428980538938c6aa2b12 schema:volumeNumber 251
96 rdf:type schema:PublicationVolume
97 Nd43c3bb1edda436bb9e3b8f9aad16495 schema:name nlm_unique_id
98 schema:value 0211301
99 rdf:type schema:PropertyValue
100 Ne8a24ed09a30472aa92a8232948fd5fe schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 Nebb9d0a46ca14dd5903dc51ac845ff9a rdf:first sg:person.01233617533.46
103 rdf:rest rdf:nil
104 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
105 schema:name Biological Sciences
106 rdf:type schema:DefinedTerm
107 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
108 schema:name Biochemistry and Cell Biology
109 rdf:type schema:DefinedTerm
110 sg:grant.5127721 http://pending.schema.org/fundedItem sg:pub.10.1007/s00232-018-0043-x
111 rdf:type schema:MonetaryGrant
112 sg:grant.6712166 http://pending.schema.org/fundedItem sg:pub.10.1007/s00232-018-0043-x
113 rdf:type schema:MonetaryGrant
114 sg:journal.1012006 schema:issn 0022-2631
115 1432-1424
116 schema:name The Journal of Membrane Biology
117 rdf:type schema:Periodical
118 sg:person.01233617533.46 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
119 schema:familyName Clarke
120 schema:givenName Ronald J.
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233617533.46
122 rdf:type schema:Person
123 sg:person.013360612424.26 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
124 schema:familyName Diaz
125 schema:givenName Dil
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013360612424.26
127 rdf:type schema:Person
128 sg:pub.10.1007/bf01870942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046010638
129 https://doi.org/10.1007/bf01870942
130 rdf:type schema:CreativeWork
131 sg:pub.10.1007/pl00006286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011413241
132 https://doi.org/10.1007/pl00006286
133 rdf:type schema:CreativeWork
134 sg:pub.10.1007/s00232-002-1041-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047083627
135 https://doi.org/10.1007/s00232-002-1041-5
136 rdf:type schema:CreativeWork
137 sg:pub.10.1007/s003600050224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005638447
138 https://doi.org/10.1007/s003600050224
139 rdf:type schema:CreativeWork
140 sg:pub.10.1007/s00424-008-0495-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046856644
141 https://doi.org/10.1007/s00424-008-0495-4
142 rdf:type schema:CreativeWork
143 sg:pub.10.1038/nature06419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046382388
144 https://doi.org/10.1038/nature06419
145 rdf:type schema:CreativeWork
146 sg:pub.10.1038/nature07939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032306700
147 https://doi.org/10.1038/nature07939
148 rdf:type schema:CreativeWork
149 sg:pub.10.1038/nature12578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023657224
150 https://doi.org/10.1038/nature12578
151 rdf:type schema:CreativeWork
152 sg:pub.10.1038/nrm3031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028033266
153 https://doi.org/10.1038/nrm3031
154 rdf:type schema:CreativeWork
155 sg:pub.10.1038/s41586-018-0003-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101862103
156 https://doi.org/10.1038/s41586-018-0003-8
157 rdf:type schema:CreativeWork
158 sg:pub.10.1385/1-59259-890-0:571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038854297
159 https://doi.org/10.1385/1-59259-890-0:571
160 rdf:type schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1077197870 schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1082569397 schema:CreativeWork
163 https://doi.org/10.1002/prot.24065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050419334
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1002/prot.24105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037273117
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1002/prot.340040204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052424463
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1006/bbrc.1996.1589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007739847
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1006/jmbi.1999.3110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002979516
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/0005-2736(75)90239-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033969747
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/0005-2736(86)90555-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038552288
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/b978-1-4832-2734-4.50017-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032138540
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.bbamem.2017.01.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053877231
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.bbamem.2018.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101358304
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.bpj.2016.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074212150
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.bpj.2018.04.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104993852
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.sbi.2012.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020775760
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/s0006-291x(88)80033-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053213988
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/s0006-3495(03)74977-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029864896
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0065-3233(02)62004-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008887485
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0959-440x(02)00289-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011350804
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1021/bi0504456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055200341
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1073/pnas.93.17.9132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001893443
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1074/jbc.270.23.14072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048279425
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1074/jbc.271.39.23683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032132370
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1074/jbc.m206115200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028879176
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1074/jbc.m705899200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016730890
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1093/bioinformatics/btn195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012413956
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/molbev/msw054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012564990
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1093/nar/gkh253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026130589
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1093/nar/gkh340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025846396
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1093/oxfordjournals.molbev.a040454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079752303
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1558-5646.1985.tb00420.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1085717760
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/j.1749-6632.1982.tb25743.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000701839
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1126/science.1243352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009080707
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1146/annurev.biochem.71.102201.141218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043362040
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1152/ajpregu.00513.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005776139
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1371/journal.pone.0134116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032907579
230 rdf:type schema:CreativeWork
231 https://doi.org/10.2170/jjphysiol.50.419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038386284
232 rdf:type schema:CreativeWork
233 https://doi.org/10.3390/polym6102684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025055021
234 rdf:type schema:CreativeWork
235 https://doi.org/10.4161/cc.4.1.1353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298075
236 rdf:type schema:CreativeWork
237 https://www.grid.ac/institutes/grid.1013.3 schema:alternateName University of Sydney
238 schema:name School of Chemistry, University of Sydney, 2006, Sydney, NSW, Australia
239 The University of Sydney Nano Institute, 2006, Sydney, NSW, Australia
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...