Content Delivery of Lipidic Nanovesicles in Electropermeabilized Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

P. Henri, R. Ospital, Justin Teissié

ABSTRACT

Lipidic nanovesicles (the so-called liposomes) were among the one of the earliest forms of nanovectors. One of their limits was our lack of knowledge on the delivery pathway of their content to the target cell cytoplasm. In most models, it appears to be linked to endocytotic transfer. Their direct content delivery can be enhanced by electric field pulses applied to a cell liposomes mixture. The optimal form for liposomes was shown to be large unilamellar vesicles (LUV). The present communication describes an optimization to enhance the delivery. When lipidic nanovesicles (LUVs) are electrostatically brought in contact with electropermeabilized cells by a salt bridge, their content is delivered into the cytoplasm of electropermeabilized cells. The PEF parameters are selected to affect specifically the cells leaving the vesicles unaffected. Cell viability is positively affected by the treatment. High-field short pulses are more efficient than low-field long pulses. A homogeneous cytoplasm labeling is observed under digitized videomicroscopy. The process is a content mixing, not an endocytotic pathway. The lipidic composition of the LUV should contain charged lipids (phosphatidylserine), fusion promoting lipids (phosphatidylethanolamine), and cholesterol. More... »

PAGES

849-855

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00232-015-9789-6

DOI

http://dx.doi.org/10.1007/s00232-015-9789-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032918571

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25796486


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electroporation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endocytosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Permeability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Unilamellar Liposomes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Pharmacology and Structural Biology", 
          "id": "https://www.grid.ac/institutes/grid.461904.e", 
          "name": [
            "CNRS UMR5089 \u2013 IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 Route de Narbonne, BP 64182, 31077, Toulouse, France", 
            "Universit\u00e9 de Toulouse, UPS, IPBS, 31077, Toulouse, France", 
            "UMR CNRS 5247, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henri", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pharmacology and Structural Biology", 
          "id": "https://www.grid.ac/institutes/grid.461904.e", 
          "name": [
            "CNRS UMR5089 \u2013 IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 Route de Narbonne, BP 64182, 31077, Toulouse, France", 
            "Universit\u00e9 de Toulouse, UPS, IPBS, 31077, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ospital", 
        "givenName": "R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pharmacology and Structural Biology", 
          "id": "https://www.grid.ac/institutes/grid.461904.e", 
          "name": [
            "CNRS UMR5089 \u2013 IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 Route de Narbonne, BP 64182, 31077, Toulouse, France", 
            "Universit\u00e9 de Toulouse, UPS, IPBS, 31077, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teissi\u00e9", 
        "givenName": "Justin", 
        "id": "sg:person.066405144.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.066405144.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bbagen.2005.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002879869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagen.2005.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002879869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(94)90005-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011377145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(94)90005-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011377145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ph.48.030186.001221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013371719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(02)02676-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014207867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijn.s68861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017548023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2012.09.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022957338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.151247498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025367823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(90)90149-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025829578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(90)90149-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025829578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00232-010-9272-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026112283", 
          "https://doi.org/10.1007/s00232-010-9272-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00232-010-9272-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026112283", 
          "https://doi.org/10.1007/s00232-010-9272-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02531316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027537169", 
          "https://doi.org/10.1007/bf02531316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(91)90163-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030895912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(91)90163-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030895912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(98)77898-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035579898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-2736(96)00228-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041994733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0602766103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046640646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep03382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051632914", 
          "https://doi.org/10.1038/srep03382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adhm.201300602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053553123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00509a022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055178678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078853711", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-10", 
    "datePublishedReg": "2015-10-01", 
    "description": "Lipidic nanovesicles (the so-called liposomes) were among the one of the earliest forms of nanovectors. One of their limits was our lack of knowledge on the delivery pathway of their content to the target cell cytoplasm. In most models, it appears to be linked to endocytotic transfer. Their direct content delivery can be enhanced by electric field pulses applied to a cell liposomes mixture. The optimal form for liposomes was shown to be large unilamellar vesicles (LUV). The present communication describes an optimization to enhance the delivery. When lipidic nanovesicles (LUVs) are electrostatically brought in contact with electropermeabilized cells by a salt bridge, their content is delivered into the cytoplasm of electropermeabilized cells. The PEF parameters are selected to affect specifically the cells leaving the vesicles unaffected. Cell viability is positively affected by the treatment. High-field short pulses are more efficient than low-field long pulses. A homogeneous cytoplasm labeling is observed under digitized videomicroscopy. The process is a content mixing, not an endocytotic pathway. The lipidic composition of the LUV should contain charged lipids (phosphatidylserine), fusion promoting lipids (phosphatidylethanolamine), and cholesterol. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00232-015-9789-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1012006", 
        "issn": [
          "0022-2631", 
          "1432-1424"
        ], 
        "name": "The Journal of Membrane Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "248"
      }
    ], 
    "name": "Content Delivery of Lipidic Nanovesicles in Electropermeabilized Cells", 
    "pagination": "849-855", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9cd1df71df58a6bba7fd26d135f07caf849053e563a2d88f88a7ede1c823c4f8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25796486"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0211301"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00232-015-9789-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032918571"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00232-015-9789-6", 
      "https://app.dimensions.ai/details/publication/pub.1032918571"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00232-015-9789-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00232-015-9789-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00232-015-9789-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00232-015-9789-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00232-015-9789-6'


 

This table displays all metadata directly associated to this object as RDF triples.

167 TRIPLES      21 PREDICATES      54 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00232-015-9789-6 schema:about N2a19878e288147678bf92cc32ec8d594
2 N317e42f5797b40f8a812c359250f4330
3 N5d9e2c7729e745038c1dd34d1e849211
4 N7f3aca2ae2bb4e10bde3d600ce23ffe0
5 Nad4eb7bf874b449297f29a7d56eeccc7
6 Nfc9d233ac5fd4d27bfe2218e1104cf08
7 Nffebf7ad780946f2b387071197bb71c2
8 anzsrc-for:06
9 anzsrc-for:0601
10 schema:author Nb62c8728aa364390b76f149dbd8ba279
11 schema:citation sg:pub.10.1007/bf02531316
12 sg:pub.10.1007/s00232-010-9272-3
13 sg:pub.10.1038/srep03382
14 https://app.dimensions.ai/details/publication/pub.1078853711
15 https://doi.org/10.1002/adhm.201300602
16 https://doi.org/10.1016/0005-2736(90)90149-i
17 https://doi.org/10.1016/0005-2736(91)90163-3
18 https://doi.org/10.1016/0005-2736(94)90005-1
19 https://doi.org/10.1016/j.addr.2012.09.037
20 https://doi.org/10.1016/j.bbagen.2005.05.006
21 https://doi.org/10.1016/s0005-2736(96)00228-3
22 https://doi.org/10.1016/s0006-3495(98)77898-1
23 https://doi.org/10.1016/s0014-5793(02)02676-5
24 https://doi.org/10.1021/bi00509a022
25 https://doi.org/10.1073/pnas.0602766103
26 https://doi.org/10.1073/pnas.151247498
27 https://doi.org/10.1146/annurev.ph.48.030186.001221
28 https://doi.org/10.2147/ijn.s68861
29 schema:datePublished 2015-10
30 schema:datePublishedReg 2015-10-01
31 schema:description Lipidic nanovesicles (the so-called liposomes) were among the one of the earliest forms of nanovectors. One of their limits was our lack of knowledge on the delivery pathway of their content to the target cell cytoplasm. In most models, it appears to be linked to endocytotic transfer. Their direct content delivery can be enhanced by electric field pulses applied to a cell liposomes mixture. The optimal form for liposomes was shown to be large unilamellar vesicles (LUV). The present communication describes an optimization to enhance the delivery. When lipidic nanovesicles (LUVs) are electrostatically brought in contact with electropermeabilized cells by a salt bridge, their content is delivered into the cytoplasm of electropermeabilized cells. The PEF parameters are selected to affect specifically the cells leaving the vesicles unaffected. Cell viability is positively affected by the treatment. High-field short pulses are more efficient than low-field long pulses. A homogeneous cytoplasm labeling is observed under digitized videomicroscopy. The process is a content mixing, not an endocytotic pathway. The lipidic composition of the LUV should contain charged lipids (phosphatidylserine), fusion promoting lipids (phosphatidylethanolamine), and cholesterol.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N12625fe3ef3f4a33baac725863207e6f
36 N7ad4505c2fd74fd4b1399a660017b97e
37 sg:journal.1012006
38 schema:name Content Delivery of Lipidic Nanovesicles in Electropermeabilized Cells
39 schema:pagination 849-855
40 schema:productId N665306868d7a4d8fa5619bf8352e6be0
41 Nc56d459fe8d94206a6d983042d18b024
42 Ne307784eec234e1c9607f693f51244e6
43 Ne4c523db8e024c82a430153ceaa213b3
44 Nec97c0de770f4fd08be30fba266aebb7
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032918571
46 https://doi.org/10.1007/s00232-015-9789-6
47 schema:sdDatePublished 2019-04-11T01:11
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher Nc442b7afa636438c84ee210aaa6fe771
50 schema:url http://link.springer.com/10.1007%2Fs00232-015-9789-6
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N12625fe3ef3f4a33baac725863207e6f schema:issueNumber 5
55 rdf:type schema:PublicationIssue
56 N2a19878e288147678bf92cc32ec8d594 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Electroporation
58 rdf:type schema:DefinedTerm
59 N317e42f5797b40f8a812c359250f4330 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Membrane Fusion
61 rdf:type schema:DefinedTerm
62 N5a7af6e8edf046da8b572f7c7d18bf00 rdf:first sg:person.066405144.83
63 rdf:rest rdf:nil
64 N5d9e2c7729e745038c1dd34d1e849211 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Humans
66 rdf:type schema:DefinedTerm
67 N665306868d7a4d8fa5619bf8352e6be0 schema:name nlm_unique_id
68 schema:value 0211301
69 rdf:type schema:PropertyValue
70 N7491421374524f04912088793522bccf schema:affiliation https://www.grid.ac/institutes/grid.461904.e
71 schema:familyName Ospital
72 schema:givenName R.
73 rdf:type schema:Person
74 N7ad4505c2fd74fd4b1399a660017b97e schema:volumeNumber 248
75 rdf:type schema:PublicationVolume
76 N7f3aca2ae2bb4e10bde3d600ce23ffe0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Unilamellar Liposomes
78 rdf:type schema:DefinedTerm
79 N9b08d0c2a1d340a3b33b466cd791ff2e schema:affiliation https://www.grid.ac/institutes/grid.461904.e
80 schema:familyName Henri
81 schema:givenName P.
82 rdf:type schema:Person
83 Nad4eb7bf874b449297f29a7d56eeccc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Phospholipids
85 rdf:type schema:DefinedTerm
86 Naed7e57d62cc4682ad3a757832c317a6 rdf:first N7491421374524f04912088793522bccf
87 rdf:rest N5a7af6e8edf046da8b572f7c7d18bf00
88 Nb62c8728aa364390b76f149dbd8ba279 rdf:first N9b08d0c2a1d340a3b33b466cd791ff2e
89 rdf:rest Naed7e57d62cc4682ad3a757832c317a6
90 Nc442b7afa636438c84ee210aaa6fe771 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 Nc56d459fe8d94206a6d983042d18b024 schema:name doi
93 schema:value 10.1007/s00232-015-9789-6
94 rdf:type schema:PropertyValue
95 Ne307784eec234e1c9607f693f51244e6 schema:name dimensions_id
96 schema:value pub.1032918571
97 rdf:type schema:PropertyValue
98 Ne4c523db8e024c82a430153ceaa213b3 schema:name pubmed_id
99 schema:value 25796486
100 rdf:type schema:PropertyValue
101 Nec97c0de770f4fd08be30fba266aebb7 schema:name readcube_id
102 schema:value 9cd1df71df58a6bba7fd26d135f07caf849053e563a2d88f88a7ede1c823c4f8
103 rdf:type schema:PropertyValue
104 Nfc9d233ac5fd4d27bfe2218e1104cf08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Endocytosis
106 rdf:type schema:DefinedTerm
107 Nffebf7ad780946f2b387071197bb71c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Permeability
109 rdf:type schema:DefinedTerm
110 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
111 schema:name Biological Sciences
112 rdf:type schema:DefinedTerm
113 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
114 schema:name Biochemistry and Cell Biology
115 rdf:type schema:DefinedTerm
116 sg:journal.1012006 schema:issn 0022-2631
117 1432-1424
118 schema:name The Journal of Membrane Biology
119 rdf:type schema:Periodical
120 sg:person.066405144.83 schema:affiliation https://www.grid.ac/institutes/grid.461904.e
121 schema:familyName Teissié
122 schema:givenName Justin
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.066405144.83
124 rdf:type schema:Person
125 sg:pub.10.1007/bf02531316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027537169
126 https://doi.org/10.1007/bf02531316
127 rdf:type schema:CreativeWork
128 sg:pub.10.1007/s00232-010-9272-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026112283
129 https://doi.org/10.1007/s00232-010-9272-3
130 rdf:type schema:CreativeWork
131 sg:pub.10.1038/srep03382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051632914
132 https://doi.org/10.1038/srep03382
133 rdf:type schema:CreativeWork
134 https://app.dimensions.ai/details/publication/pub.1078853711 schema:CreativeWork
135 https://doi.org/10.1002/adhm.201300602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053553123
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1016/0005-2736(90)90149-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1025829578
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1016/0005-2736(91)90163-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030895912
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1016/0005-2736(94)90005-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011377145
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1016/j.addr.2012.09.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022957338
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1016/j.bbagen.2005.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002879869
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/s0005-2736(96)00228-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041994733
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/s0006-3495(98)77898-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035579898
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/s0014-5793(02)02676-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014207867
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1021/bi00509a022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055178678
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1073/pnas.0602766103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046640646
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1073/pnas.151247498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025367823
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1146/annurev.ph.48.030186.001221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013371719
160 rdf:type schema:CreativeWork
161 https://doi.org/10.2147/ijn.s68861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017548023
162 rdf:type schema:CreativeWork
163 https://www.grid.ac/institutes/grid.461904.e schema:alternateName Institute of Pharmacology and Structural Biology
164 schema:name CNRS UMR5089 – IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 Route de Narbonne, BP 64182, 31077, Toulouse, France
165 UMR CNRS 5247, Montpellier, France
166 Université de Toulouse, UPS, IPBS, 31077, Toulouse, France
167 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...