Effect of food on the bioavailability of oxybutynin from a controlled release tablet View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

E. Lukkari, P. Castrèn-Kortekangas, A. Juhakoski, E. Löyttyniemi, K. Aranko, P. J. Neuvonen

ABSTRACT

OBJECTIVE: The effect of food on the bioavailability of oxybutynin was assessed in a randomised cross-over study in 23 healthy volunteers. A single oral 10 mg dose of a controlled release oxybutynin tablet was administered after a high fat breakfast and to fasting subjects. The AUC, Cmax, tmax, t1/2 and MRT of oxybutynin and its active metabolite N-desethyloxybutynin were determined. RESULTS: Breakfast did not change the AUC of oxybutynin but increased the AUC of N-desethyloxybutynin by about 20%. The Cmax of oxybutynin and N-desethyloxybutynin were two-fold higher when the drug was administered after breakfast compared to the fasting state. CONCLUSION: Breakfast significantly reduced the MRT of oxybutynin and N-desethyloxybutynin. More... »

PAGES

221-223

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002280050096

DOI

http://dx.doi.org/10.1007/s002280050096

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016600665

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8737763


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