Ontology type: schema:ScholarlyArticle
2019-04
AUTHORSNingyuan Zhang, Yinghua Lv, Huafang Li, Junchao Chen, Yunfei Li, Fang Yin, Lujin Li, Qingshan Zheng
ABSTRACTPURPOSE: This study aimed to establish a non-linear mixed effects model to quantitatively analyze the placebo responses of neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD). METHODS: A comprehensive literature search was conducted in public databases. Placebo-controlled randomized AD clinical trials using the neuropsychiatric inventory (NPI) score as the primary or secondary outcome were included. Non-linear mixed effects model was used to describe the time course of the placebo responses of NPS in AD clinical trials. Potential affecting factors were tested as covariates. RESULTS: A total of 32 clinical studies (involving 3942 subjects) were included in model-based analysis. We found that the maximal placebo responses of NPS were reached at week 4 approximately, after which rebound effects appeared. The baseline NPI score had a significant impact on the placebo responses. Higher baseline NPI score tended to cause greater reductions in NPI score at week 8 and a smaller degree of rebound. For AD patients whose normalized baseline NPI score was 10 points and 30 points, the reduction in normalized NPI score at week 8 was estimated to be 0.83 and 7.43 points, respectively; and the rebound rate after week 8 was estimated to be 0.1 points/week and 0.08 points/week, respectively. CONCLUSIONS: The duration of 4 weeks is sufficient to determine the drug efficacy for assessing NPS in AD clinical trials. The baseline NPI score was a key factor associated with placebo responses of NPS, which should be considered when designing future clinical trials and conducting comparisons across trials. More... »
PAGES497-509
http://scigraph.springernature.com/pub.10.1007/s00228-018-02620-x
DOIhttp://dx.doi.org/10.1007/s00228-018-02620-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111157092
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30612155
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Shanghai University of Traditional Chinese Medicine",
"id": "https://www.grid.ac/institutes/grid.412540.6",
"name": [
"Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Zhang",
"givenName": "Ningyuan",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shanghai University of Traditional Chinese Medicine",
"id": "https://www.grid.ac/institutes/grid.412540.6",
"name": [
"Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Lv",
"givenName": "Yinghua",
"id": "sg:person.01053263346.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053263346.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shanghai Mental Health Center",
"id": "https://www.grid.ac/institutes/grid.415630.5",
"name": [
"Shanghai Mental Health Center, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Huafang",
"id": "sg:person.0632156532.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632156532.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shanghai University of Traditional Chinese Medicine",
"id": "https://www.grid.ac/institutes/grid.412540.6",
"name": [
"Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Junchao",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shanghai University of Traditional Chinese Medicine",
"id": "https://www.grid.ac/institutes/grid.412540.6",
"name": [
"Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Yunfei",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shanghai University of Traditional Chinese Medicine",
"id": "https://www.grid.ac/institutes/grid.412540.6",
"name": [
"Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Yin",
"givenName": "Fang",
"id": "sg:person.010445503023.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010445503023.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shanghai University of Traditional Chinese Medicine",
"id": "https://www.grid.ac/institutes/grid.412540.6",
"name": [
"Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Lujin",
"id": "sg:person.0776336240.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776336240.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shanghai University of Traditional Chinese Medicine",
"id": "https://www.grid.ac/institutes/grid.412540.6",
"name": [
"Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China"
],
"type": "Organization"
},
"familyName": "Zheng",
"givenName": "Qingshan",
"id": "sg:person.0611706517.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611706517.12"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.jalz.2010.03.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002016338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00019442-200002000-00010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003976350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archpsyc.57.10.968",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009391426"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.0050076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010235795"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.jgp.0000224350.82719.83",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011453476"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/gps.1032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011927118"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jalz.2009.05.665",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012812367"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.trci.2016.11.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013155070"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/npp.2011.306",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014638877",
"https://doi.org/10.1038/npp.2011.306"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11920-014-0470-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015049697",
"https://doi.org/10.1007/s11920-014-0470-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jalz.2007.10.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017957715"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1011527125570",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020213805",
"https://doi.org/10.1023/a:1011527125570"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa066583",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020350218"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1532-5415.2001.49266.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021460615"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/wad.0b013e318065c495",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022651573"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/wad.0b013e318065c495",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022651573"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.89.23.11466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023494902"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1468-1331.2010.03040.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023694535"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(06)68350-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024312268"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archneur.62.5.753",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026084740"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jnnp-2014-308112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026752761"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10928-012-9263-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027409616",
"https://doi.org/10.1007/s10928-012-9263-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.jcp.0000178415.22309.8f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028003352"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.jcp.0000178415.22309.8f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028003352"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.jcp.0000178415.22309.8f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028003352"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jalz.2016.08.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029398986"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.294.15.1934",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030157525"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jnnp.71.5.589",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031490694"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/gps.1788",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034377444"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.289.21.2819",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034936315"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa013128",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035088478"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0001475",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035131326"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/089198870101400211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035612555"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/089198870101400211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035612555"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0035185",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036923799"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/jgp.0b013e3181557b47",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037786866"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/s1041610215001106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038439067"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000086613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042819899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000086613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042819899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2015.10214",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043301772"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/jgp.0b013e318165db77",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049224583"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/s1041610213000239",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049327896"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1468-1331.2006.01222.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050125089"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1468-1331.2006.01222.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050125089"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jalz.2015.08.138",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052689046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1176/appi.ajp.2008.07111779",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063498116"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000260240.46070.7c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064349140"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000260240.46070.7c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064349140"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000260240.46070.7c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064349140"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000266627.96040.5a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064349384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000266627.96040.5a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064349384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000266627.96040.5a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064349384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e318216eb7b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064356106"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e318216eb7b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064356106"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e318216eb7b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064356106"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.44.12.2308",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064372220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.48.5_suppl_6.10s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064374999"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.48.5_suppl_6.10s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064374999"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.48.5_suppl_6.10s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064374999"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.54.12.2269",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064378228"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.57.4.613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064380021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.57.4.613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064380021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.57.4.613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064380021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/1567205011666140505100858",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069188172"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4088/jcp.v65n0120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072208694"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077894111",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3233/jad-130575",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078748893"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jagp.2017.02.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084084199"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-04",
"datePublishedReg": "2019-04-01",
"description": "PURPOSE: This study aimed to establish a non-linear mixed effects model to quantitatively analyze the placebo responses of neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD).\nMETHODS: A comprehensive literature search was conducted in public databases. Placebo-controlled randomized AD clinical trials using the neuropsychiatric inventory (NPI) score as the primary or secondary outcome were included. Non-linear mixed effects model was used to describe the time course of the placebo responses of NPS in AD clinical trials. Potential affecting factors were tested as covariates.\nRESULTS: A total of 32 clinical studies (involving 3942 subjects) were included in model-based analysis. We found that the maximal placebo responses of NPS were reached at week 4 approximately, after which rebound effects appeared. The baseline NPI score had a significant impact on the placebo responses. Higher baseline NPI score tended to cause greater reductions in NPI score at week 8 and a smaller degree of rebound. For AD patients whose normalized baseline NPI score was 10 points and 30 points, the reduction in normalized NPI score at week 8 was estimated to be 0.83 and 7.43 points, respectively; and the rebound rate after week 8 was estimated to be 0.1 points/week and 0.08 points/week, respectively.\nCONCLUSIONS: The duration of 4\u00a0weeks is sufficient to determine the drug efficacy for assessing NPS in AD clinical trials. The baseline NPI score was a key factor associated with placebo responses of NPS, which should be considered when designing future clinical trials and conducting comparisons across trials.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00228-018-02620-x",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1054337",
"issn": [
"0031-6970",
"1432-1041"
],
"name": "European Journal of Clinical Pharmacology",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "75"
}
],
"name": "Quantifying placebo responses in clinical evaluation of neuropsychiatric symptoms in Alzheimer\u2019s disease",
"pagination": "497-509",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"00ebfcb6828b07a9b5284a7516c0bae87c2ee436e43bc6c1f31fa6d73287a6f9"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30612155"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"1256165"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00228-018-02620-x"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111157092"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00228-018-02620-x",
"https://app.dimensions.ai/details/publication/pub.1111157092"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:20",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78965_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs00228-018-02620-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00228-018-02620-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00228-018-02620-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00228-018-02620-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00228-018-02620-x'
This table displays all metadata directly associated to this object as RDF triples.
277 TRIPLES
21 PREDICATES
81 URIs
21 LITERALS
9 BLANK NODES