Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

Thomas M. Caparrotta, Daniel J. Antoine, James W. Dear

ABSTRACT

PURPOSE: Paracetamol is one of the world's most commonly used drugs. In overdose, it is well established to be hepatotoxic. The aim of this review was to identify factors that have been, or actually are, associated with the development of liver injury after paracetamol exposure in humans. METHOD: Google Scholar and PubMed were searched on various dates between December 2016 and March 2017. Papers identified had their references analysed for further studies that might be relevant. RESULTS: At the time of writing, there was little good quality clinical evidence-from studies of paracetamol overdose or therapeutic use-to suggest that any groups of people are relatively protected from, or are at greater risk of, liver injury. The factors that were historically used to indicate higher risk in the UK have no good quality clinical evidence to support their re-introduction into clinical practice. The safe (and still effective) oral dose of paracetamol in patients weighing less than 50 kg has not been established. CONCLUSION: There is no patient group that is unequivocally at elevated risk of paracetamol-induced liver toxicity. We propose two clinical scenarios that warrant further research. Firstly, there is a need to establish whether the dose of paracetamol should be reduced in patients with low body weight. Secondly, if or when genomic information regarding individual patients becomes readily available to inform prescribing, we propose the contribution of the genome to paracetamol toxicity should be re-investigated with robustly designed studies. Such studies could enhance the safe use of one of the most frequently taken drugs. More... »

PAGES

147-160

References to SciGraph publications

  • 1999-03. Heterogeneity of paracetamol metabolism in Gilbert’s syndrome in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • 2002-05. Sulfation through the looking glass—recent advances in sulfotransferase research for the curious in THE PHARMACOGENOMICS JOURNAL
  • 2011-02. Pharmacokinetics of Intravenous Paracetamol in Elderly Patients in CLINICAL PHARMACOKINETICS
  • 1979-11. Paracetamol metabolism in chronic liver disease in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1978-05. Paracetamol (acetaminophen) kinetics in patients with Gilbert's syndrome in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1999-02. Acetaminophen hepatotoxicity: An update in CURRENT GASTROENTEROLOGY REPORTS
  • 1982-02. Acetaminophen kinetics in the elderly in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2000-03. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1980-07. Measurement of hepatic drug-metabolizing enzyme activity in man in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1988-03. Comparison of paracetamol metabolism in young adult and elderly males in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1997-07. The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S‐mephenytoin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2013-09. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis in PHARMACEUTICAL RESEARCH
  • 2003-07. Paracetamol and metabolite pharmacokinetics in infants in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1986-09. Reduction of Paracetamol and Aspirin Metabolism During Viral Hepatitis in CLINICAL PHARMACOKINETICS
  • 1984-09. Acetaminophen accumulation in pediatric patients after repeated therapeutic doses in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1986-01. Lethal enhancement of therapeutic doses of acetaminophen by alcohol in DIGESTIVE DISEASES AND SCIENCES
  • 1983-01. Acetaminophen in chronic liver disease in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2011-11. Acetaminophen Metabolism After Major Surgery: A Greater Challenge With Increasing Age in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1977-07. Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2000-06. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2011-04. Mechanisms of drug-induced liver injury: from bedside to bench in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 1975-01. Pharmacokinetics in the elderly in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2001-05. Substances used in deliberate self-poisoning 1985–1997: trends and associations with age, gender, repetition and suicide intent in SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
  • 2013-02. Transplantation for Acute Liver Failure in Patients Exposed to NSAIDs or Paracetamol (Acetaminophen) in DRUG SAFETY
  • 2014-12. A randomized, placebo-controlled trial to determine the course of aminotransferase elevation during prolonged acetaminophen administration in BMC PHARMACOLOGY AND TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00228-017-2356-6

    DOI

    http://dx.doi.org/10.1007/s00228-017-2356-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092338475

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29067481


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acetaminophen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Analgesics, Non-Narcotic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemical and Drug Induced Liver Injury", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "NHS Lothian", 
              "id": "https://www.grid.ac/institutes/grid.39489.3f", 
              "name": [
                "Speciality Registrar Clinical Pharmacology and Therapeutics, NHS Lothian, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caparrotta", 
            "givenName": "Thomas M.", 
            "id": "sg:person.013646156163.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013646156163.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Edinburgh", 
              "id": "https://www.grid.ac/institutes/grid.4305.2", 
              "name": [
                "MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Antoine", 
            "givenName": "Daniel J.", 
            "id": "sg:person.0664363247.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664363247.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Edinburgh", 
              "id": "https://www.grid.ac/institutes/grid.4305.2", 
              "name": [
                "University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dear", 
            "givenName": "James W.", 
            "id": "sg:person.01027656510.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027656510.58"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1136/bmj.2.6135.478-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000342220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.d2218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000536073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005792-199705000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000961352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005792-199705000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000961352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11894-999-0086-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003236915", 
              "https://doi.org/10.1007/s11894-999-0086-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02395207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003244760", 
              "https://doi.org/10.1007/bf02395207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02395207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003244760", 
              "https://doi.org/10.1007/bf02395207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.1991.tb03989.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003321541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0031-6989(82)80052-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004203852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/03602532.2010.527984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004562937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00045391-200205000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004590101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00045391-200205000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004590101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2796.2003.01097.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005100239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2004.054619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005142326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2011.176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005200885", 
              "https://doi.org/10.1038/clpt.2011.176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.1984.tb02453.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005847026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cpt1979264483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005944705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.1840220312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006162901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.1992.tb04112.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006167453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00609245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007201329", 
              "https://doi.org/10.1007/bf00609245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00609245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007201329", 
              "https://doi.org/10.1007/bf00609245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2362.1987.tb01242.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007429969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.161.18.2247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007815105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.1991.tb03873.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007946846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.20300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008913334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2050-6511-15-39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009578278", 
              "https://doi.org/10.1186/2050-6511-15-39"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/07357909609012140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010472509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.29.9.1153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012556582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1345/aph.1a035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012558093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1345/aph.1a035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012558093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199710163371602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013937413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/13556210220120424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014645555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003088-198611030-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015838131", 
              "https://doi.org/10.2165/00003088-198611030-00006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(95)91385-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016119455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(95)91385-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016119455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.1992.tb00926.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016379016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00609984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016606009", 
              "https://doi.org/10.1007/bf00609984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00609984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016606009", 
              "https://doi.org/10.1007/bf00609984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00609984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016606009", 
              "https://doi.org/10.1007/bf00609984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11537240-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016756708", 
              "https://doi.org/10.2165/11537240-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11537240-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016756708", 
              "https://doi.org/10.2165/11537240-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bcp.12362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016978216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1986.03370190120036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017198518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.tpj.6500117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018073588", 
              "https://doi.org/10.1038/sj.tpj.6500117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.tpj.6500117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018073588", 
              "https://doi.org/10.1038/sj.tpj.6500117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1997.7466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018577889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2036.2002.01224.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018982256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00561743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019554449", 
              "https://doi.org/10.1007/bf00561743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00561743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019554449", 
              "https://doi.org/10.1007/bf00561743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40264-012-0013-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019632380", 
              "https://doi.org/10.1007/s40264-012-0013-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40264-012-0013-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019632380", 
              "https://doi.org/10.1007/s40264-012-0013-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2796.2003.01107.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019942489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/clt-120030940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019966006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(84)80376-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020701134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2125.2000.00167.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021081403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2710.2000.00282.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021412035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1067/mcp.2000.106574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021572787", 
              "https://doi.org/10.1067/mcp.2000.106574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2710.2000.00301.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021808972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2710.2000.00301.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021808972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0009-2797(94)03587-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022474329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.1991.00400060113019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022525531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2011.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022657948", 
              "https://doi.org/10.1038/nrgastro.2011.22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0470011815.b2a17103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023251584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.1983.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024024536", 
              "https://doi.org/10.1038/clpt.1983.14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.113.053546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025534056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1366-0071(99)80006-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026157108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1366-0071(99)80006-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026157108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/fn.80.1.f59", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026614689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(83)92150-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026906907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1532-5415.1976.tb03312.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027118945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00607678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027133220", 
              "https://doi.org/10.1007/bf00607678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00607678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027133220", 
              "https://doi.org/10.1007/bf00607678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00607678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027133220", 
              "https://doi.org/10.1007/bf00607678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1994.03520230055038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027184210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bcp.12831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027939188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.1981.00340030122022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029126625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1399-6576.2001.450104.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029257367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/clt-120002882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029320388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinthera.2006.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031328121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/toxsci/49.2.156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031929178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0954-6820.1987.tb10672.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031936769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0954-6820.1987.tb10672.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031936769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1067/mcp.2000.104736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032350454", 
              "https://doi.org/10.1067/mcp.2000.104736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00616415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033579096", 
              "https://doi.org/10.1007/bf00616415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00616415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033579096", 
              "https://doi.org/10.1007/bf00616415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.1986.tb02953.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033624878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1542/peds.2011-2345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034148324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01347918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034271481", 
              "https://doi.org/10.1007/bf01347918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ejp.621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034605882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000108654.77178.03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034991640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000108654.77178.03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034991640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpedi.1984.02140430006003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035015287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1460-9592.1998.00295.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035154821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1460-9592.1998.00295.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035154821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2010.04.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035368758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/15563650.2014.987397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035760423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2044.2007.05340.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036040676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-013-1007-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036906108", 
              "https://doi.org/10.1007/s11095-013-1007-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1592/phco.27.9.1219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037331272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.1980.tb01812.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037918584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(98)70479-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039032818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(00)85930-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040007763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0003-9861(88)90592-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040210141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.2011.04067.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040303968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1553-2712.2007.00019.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040454613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.2.6198.1097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040777426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(95)90758-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040942866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0009-9236(97)90148-xb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041471051", 
              "https://doi.org/10.1016/s0009-9236(97)90148-xb"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00228-003-0608-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043180544", 
              "https://doi.org/10.1007/s00228-003-0608-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03190005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044196718", 
              "https://doi.org/10.1007/bf03190005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinthera.2006.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044761812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.090241.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046419737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00045391-200007020-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046607284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00045391-200007020-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046607284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(93)90437-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046713020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(93)90437-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046713020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.1.6073.1384", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046925347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001270170053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047440048", 
              "https://doi.org/10.1007/s001270170053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.1973.tb08536.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048023151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00625800", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048173482", 
              "https://doi.org/10.1007/bf00625800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.296.1.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048559401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0735-6757(88)90044-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048617014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00045391-200501000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049085716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00045391-200501000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049085716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.me.35.020184.003045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049694169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(77)80787-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050207171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0954-6820.1979.tb00728.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050995699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0954-6820.1979.tb00728.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050995699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00365518109090500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051276764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3810/pgm.2000.01.831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051693754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(97)70359-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051711649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.112.202010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052248549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(92)90106-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052404249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/qjmed/93.6.341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052628863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2710.2010.01193.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052707562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cpt1976193284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052750880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(71)91125-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052753155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(71)91125-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052753155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.1992.tb00976.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053042330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.1992.tb00976.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053042330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.1982.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053744347", 
              "https://doi.org/10.1038/clpt.1982.24"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2710.2000.00301.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056736484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ageing/19.6.419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059368409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.c6764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062808070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.c6764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062808070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-104-3-399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073690815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-104-3-427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073690820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-92-4-511_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073737679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074763545", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078032015", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007611-199009000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078784969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007611-199009000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078784969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007611-199009000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078784969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080349085", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080564516", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080564519", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082069239", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082176651", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082822613", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083009656", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cpt.690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084514176"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-02", 
        "datePublishedReg": "2018-02-01", 
        "description": "PURPOSE: Paracetamol is one of the world's most commonly used drugs. In overdose, it is well established to be hepatotoxic. The aim of this review was to identify factors that have been, or actually are, associated with the development of liver injury after paracetamol exposure in humans.\nMETHOD: Google Scholar and PubMed were searched on various dates between December 2016 and March 2017. Papers identified had their references analysed for further studies that might be relevant.\nRESULTS: At the time of writing, there was little good quality clinical evidence-from studies of paracetamol overdose or therapeutic use-to suggest that any groups of people are relatively protected from, or are at greater risk of, liver injury. The factors that were historically used to indicate higher risk in the UK have no good quality clinical evidence to support their re-introduction into clinical practice. The safe (and still effective) oral dose of paracetamol in patients weighing less than 50\u00a0kg has not been established.\nCONCLUSION: There is no patient group that is unequivocally at elevated risk of paracetamol-induced liver toxicity. We propose two clinical scenarios that warrant further research. Firstly, there is a need to establish whether the dose of paracetamol should be reduced in patients with low body weight. Secondly, if or when genomic information regarding individual patients becomes readily available to inform prescribing, we propose the contribution of the genome to paracetamol toxicity should be re-investigated with robustly designed studies. Such studies could enhance the safe use of one of the most frequently taken drugs.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00228-017-2356-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1054337", 
            "issn": [
              "0031-6970", 
              "1432-1041"
            ], 
            "name": "European Journal of Clinical Pharmacology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "74"
          }
        ], 
        "name": "Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature", 
        "pagination": "147-160", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "06019394b6201ebcff88e1c33da67fe72c439de366d2b42a68b819784edbfe6d"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29067481"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "1256165"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00228-017-2356-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1092338475"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00228-017-2356-6", 
          "https://app.dimensions.ai/details/publication/pub.1092338475"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000569.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00228-017-2356-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00228-017-2356-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00228-017-2356-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00228-017-2356-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00228-017-2356-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    519 TRIPLES      21 PREDICATES      166 URIs      26 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00228-017-2356-6 schema:about N2bc7990d9ff848cc980c14814fc6225c
    2 N4628513d52b3439c9e2b003080c3f54e
    3 N88bd7465b12449999502c3bf9aa46ae3
    4 Na68ae2c5bcb04b2593d37565638ab737
    5 Nd077817d95484a6abf015bc2695b9501
    6 anzsrc-for:11
    7 anzsrc-for:1103
    8 schema:author N45e4cce376a3467aad4f1ef7b16e4852
    9 schema:citation sg:pub.10.1007/bf00561743
    10 sg:pub.10.1007/bf00607678
    11 sg:pub.10.1007/bf00609245
    12 sg:pub.10.1007/bf00609984
    13 sg:pub.10.1007/bf00616415
    14 sg:pub.10.1007/bf00625800
    15 sg:pub.10.1007/bf01347918
    16 sg:pub.10.1007/bf02395207
    17 sg:pub.10.1007/bf03190005
    18 sg:pub.10.1007/s001270170053
    19 sg:pub.10.1007/s00228-003-0608-0
    20 sg:pub.10.1007/s11095-013-1007-6
    21 sg:pub.10.1007/s11894-999-0086-3
    22 sg:pub.10.1007/s40264-012-0013-7
    23 sg:pub.10.1016/s0009-9236(97)90148-xb
    24 sg:pub.10.1038/clpt.1982.24
    25 sg:pub.10.1038/clpt.1983.14
    26 sg:pub.10.1038/clpt.2011.176
    27 sg:pub.10.1038/nrgastro.2011.22
    28 sg:pub.10.1038/sj.tpj.6500117
    29 sg:pub.10.1067/mcp.2000.104736
    30 sg:pub.10.1067/mcp.2000.106574
    31 sg:pub.10.1186/2050-6511-15-39
    32 sg:pub.10.2165/00003088-198611030-00006
    33 sg:pub.10.2165/11537240-000000000-00000
    34 https://app.dimensions.ai/details/publication/pub.1074763545
    35 https://app.dimensions.ai/details/publication/pub.1078032015
    36 https://app.dimensions.ai/details/publication/pub.1080349085
    37 https://app.dimensions.ai/details/publication/pub.1080564516
    38 https://app.dimensions.ai/details/publication/pub.1080564519
    39 https://app.dimensions.ai/details/publication/pub.1082069239
    40 https://app.dimensions.ai/details/publication/pub.1082176651
    41 https://app.dimensions.ai/details/publication/pub.1082822613
    42 https://app.dimensions.ai/details/publication/pub.1083009656
    43 https://doi.org/10.1001/archinte.161.18.2247
    44 https://doi.org/10.1001/archinte.1981.00340030122022
    45 https://doi.org/10.1001/archinte.1991.00400060113019
    46 https://doi.org/10.1001/archpedi.1984.02140430006003
    47 https://doi.org/10.1001/jama.1986.03370190120036
    48 https://doi.org/10.1001/jama.1994.03520230055038
    49 https://doi.org/10.1001/jama.296.1.87
    50 https://doi.org/10.1002/0470011815.b2a17103
    51 https://doi.org/10.1002/cpt.690
    52 https://doi.org/10.1002/cpt1976193284
    53 https://doi.org/10.1002/cpt1979264483
    54 https://doi.org/10.1002/ejp.621
    55 https://doi.org/10.1002/hep.1840220312
    56 https://doi.org/10.1002/hep.20300
    57 https://doi.org/10.1006/bbrc.1997.7466
    58 https://doi.org/10.1016/0003-9861(88)90592-9
    59 https://doi.org/10.1016/0006-2952(93)90437-2
    60 https://doi.org/10.1016/0009-2797(94)03587-x
    61 https://doi.org/10.1016/0016-5085(92)90106-9
    62 https://doi.org/10.1016/0016-5085(95)90758-0
    63 https://doi.org/10.1016/0735-6757(88)90044-7
    64 https://doi.org/10.1016/j.bcp.2010.04.034
    65 https://doi.org/10.1016/j.clinthera.2006.02.004
    66 https://doi.org/10.1016/j.clinthera.2006.05.002
    67 https://doi.org/10.1016/s0016-5085(00)85930-2
    68 https://doi.org/10.1016/s0022-3476(77)80787-7
    69 https://doi.org/10.1016/s0022-3476(84)80376-5
    70 https://doi.org/10.1016/s0022-3476(97)70359-7
    71 https://doi.org/10.1016/s0022-3476(98)70479-2
    72 https://doi.org/10.1016/s0031-6989(82)80052-0
    73 https://doi.org/10.1016/s0140-6736(71)91125-1
    74 https://doi.org/10.1016/s0140-6736(83)92150-5
    75 https://doi.org/10.1016/s0140-6736(95)91385-8
    76 https://doi.org/10.1016/s1366-0071(99)80006-0
    77 https://doi.org/10.1034/j.1399-6576.2001.450104.x
    78 https://doi.org/10.1046/j.1365-2036.2002.01224.x
    79 https://doi.org/10.1046/j.1365-2125.2000.00167.x
    80 https://doi.org/10.1046/j.1365-2710.2000.00282.x
    81 https://doi.org/10.1046/j.1365-2710.2000.00301.x
    82 https://doi.org/10.1046/j.1365-2796.2003.01097.x
    83 https://doi.org/10.1046/j.1365-2796.2003.01107.x
    84 https://doi.org/10.1046/j.1460-9592.1998.00295.x
    85 https://doi.org/10.1056/nejm199710163371602
    86 https://doi.org/10.1080/13556210220120424
    87 https://doi.org/10.1081/clt-120002882
    88 https://doi.org/10.1081/clt-120030940
    89 https://doi.org/10.1093/ageing/19.6.419
    90 https://doi.org/10.1093/qjmed/93.6.341
    91 https://doi.org/10.1093/toxsci/49.2.156
    92 https://doi.org/10.1097/00005792-199705000-00004
    93 https://doi.org/10.1097/00007611-199009000-00017
    94 https://doi.org/10.1097/00045391-200007020-00009
    95 https://doi.org/10.1097/00045391-200205000-00008
    96 https://doi.org/10.1097/00045391-200501000-00009
    97 https://doi.org/10.1097/01.alc.0000108654.77178.03
    98 https://doi.org/10.1101/gr.090241.108
    99 https://doi.org/10.1111/bcp.12362
    100 https://doi.org/10.1111/bcp.12831
    101 https://doi.org/10.1111/j.0954-6820.1979.tb00728.x
    102 https://doi.org/10.1111/j.0954-6820.1987.tb10672.x
    103 https://doi.org/10.1111/j.1365-2044.2007.05340.x
    104 https://doi.org/10.1111/j.1365-2125.1980.tb01812.x
    105 https://doi.org/10.1111/j.1365-2125.1984.tb02453.x
    106 https://doi.org/10.1111/j.1365-2125.1986.tb02953.x
    107 https://doi.org/10.1111/j.1365-2125.1991.tb03873.x
    108 https://doi.org/10.1111/j.1365-2125.1991.tb03989.x
    109 https://doi.org/10.1111/j.1365-2125.1992.tb04112.x
    110 https://doi.org/10.1111/j.1365-2125.2011.04067.x
    111 https://doi.org/10.1111/j.1365-2362.1987.tb01242.x
    112 https://doi.org/10.1111/j.1365-2710.2000.00301.x
    113 https://doi.org/10.1111/j.1365-2710.2010.01193.x
    114 https://doi.org/10.1111/j.1365-2796.1992.tb00976.x
    115 https://doi.org/10.1111/j.1440-1746.1992.tb00926.x
    116 https://doi.org/10.1111/j.1476-5381.1973.tb08536.x
    117 https://doi.org/10.1111/j.1532-5415.1976.tb03312.x
    118 https://doi.org/10.1111/j.1553-2712.2007.00019.x
    119 https://doi.org/10.1124/dmd.113.053546
    120 https://doi.org/10.1124/jpet.112.202010
    121 https://doi.org/10.1136/bmj.1.6073.1384
    122 https://doi.org/10.1136/bmj.2.6135.478-a
    123 https://doi.org/10.1136/bmj.2.6198.1097
    124 https://doi.org/10.1136/bmj.c6764
    125 https://doi.org/10.1136/bmj.d2218
    126 https://doi.org/10.1136/fn.80.1.f59
    127 https://doi.org/10.1136/gut.2004.054619
    128 https://doi.org/10.1136/gut.29.9.1153
    129 https://doi.org/10.1146/annurev.me.35.020184.003045
    130 https://doi.org/10.1345/aph.1a035
    131 https://doi.org/10.1542/peds.2011-2345
    132 https://doi.org/10.1592/phco.27.9.1219
    133 https://doi.org/10.3109/00365518109090500
    134 https://doi.org/10.3109/03602532.2010.527984
    135 https://doi.org/10.3109/07357909609012140
    136 https://doi.org/10.3109/15563650.2014.987397
    137 https://doi.org/10.3810/pgm.2000.01.831
    138 https://doi.org/10.7326/0003-4819-104-3-399
    139 https://doi.org/10.7326/0003-4819-104-3-427
    140 https://doi.org/10.7326/0003-4819-92-4-511_1
    141 schema:datePublished 2018-02
    142 schema:datePublishedReg 2018-02-01
    143 schema:description PURPOSE: Paracetamol is one of the world's most commonly used drugs. In overdose, it is well established to be hepatotoxic. The aim of this review was to identify factors that have been, or actually are, associated with the development of liver injury after paracetamol exposure in humans. METHOD: Google Scholar and PubMed were searched on various dates between December 2016 and March 2017. Papers identified had their references analysed for further studies that might be relevant. RESULTS: At the time of writing, there was little good quality clinical evidence-from studies of paracetamol overdose or therapeutic use-to suggest that any groups of people are relatively protected from, or are at greater risk of, liver injury. The factors that were historically used to indicate higher risk in the UK have no good quality clinical evidence to support their re-introduction into clinical practice. The safe (and still effective) oral dose of paracetamol in patients weighing less than 50 kg has not been established. CONCLUSION: There is no patient group that is unequivocally at elevated risk of paracetamol-induced liver toxicity. We propose two clinical scenarios that warrant further research. Firstly, there is a need to establish whether the dose of paracetamol should be reduced in patients with low body weight. Secondly, if or when genomic information regarding individual patients becomes readily available to inform prescribing, we propose the contribution of the genome to paracetamol toxicity should be re-investigated with robustly designed studies. Such studies could enhance the safe use of one of the most frequently taken drugs.
    144 schema:genre research_article
    145 schema:inLanguage en
    146 schema:isAccessibleForFree true
    147 schema:isPartOf N5391f118de384228bb88f98f89e7cfb7
    148 N9e940dc8d7f649a6b683a3ed9bf087a0
    149 sg:journal.1054337
    150 schema:name Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature
    151 schema:pagination 147-160
    152 schema:productId N9883ba7431184eac9c8cfe89c83bc709
    153 Na440acd1b0924b41bfebe73a3e7b1b26
    154 Nc47262afaf50468086ed15fa18fdda80
    155 Ne83a08115ea14172a3f4474f6fb9b877
    156 Nf8d50722629041f3800af5d52979a38b
    157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092338475
    158 https://doi.org/10.1007/s00228-017-2356-6
    159 schema:sdDatePublished 2019-04-10T17:40
    160 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    161 schema:sdPublisher N17708d977ed0478fa83cae2200b4e277
    162 schema:url https://link.springer.com/10.1007%2Fs00228-017-2356-6
    163 sgo:license sg:explorer/license/
    164 sgo:sdDataset articles
    165 rdf:type schema:ScholarlyArticle
    166 N17708d977ed0478fa83cae2200b4e277 schema:name Springer Nature - SN SciGraph project
    167 rdf:type schema:Organization
    168 N2bc7990d9ff848cc980c14814fc6225c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Chemical and Drug Induced Liver Injury
    170 rdf:type schema:DefinedTerm
    171 N45e4cce376a3467aad4f1ef7b16e4852 rdf:first sg:person.013646156163.49
    172 rdf:rest N8ef05b8665e447aa87ffcfb1ecb0e58f
    173 N4628513d52b3439c9e2b003080c3f54e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Risk Factors
    175 rdf:type schema:DefinedTerm
    176 N5391f118de384228bb88f98f89e7cfb7 schema:issueNumber 2
    177 rdf:type schema:PublicationIssue
    178 N88bd7465b12449999502c3bf9aa46ae3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Analgesics, Non-Narcotic
    180 rdf:type schema:DefinedTerm
    181 N8ef05b8665e447aa87ffcfb1ecb0e58f rdf:first sg:person.0664363247.31
    182 rdf:rest Nb1b85e9ba0294027b28646a814ae348f
    183 N9883ba7431184eac9c8cfe89c83bc709 schema:name doi
    184 schema:value 10.1007/s00228-017-2356-6
    185 rdf:type schema:PropertyValue
    186 N9e940dc8d7f649a6b683a3ed9bf087a0 schema:volumeNumber 74
    187 rdf:type schema:PublicationVolume
    188 Na440acd1b0924b41bfebe73a3e7b1b26 schema:name pubmed_id
    189 schema:value 29067481
    190 rdf:type schema:PropertyValue
    191 Na68ae2c5bcb04b2593d37565638ab737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Humans
    193 rdf:type schema:DefinedTerm
    194 Nb1b85e9ba0294027b28646a814ae348f rdf:first sg:person.01027656510.58
    195 rdf:rest rdf:nil
    196 Nc47262afaf50468086ed15fa18fdda80 schema:name nlm_unique_id
    197 schema:value 1256165
    198 rdf:type schema:PropertyValue
    199 Nd077817d95484a6abf015bc2695b9501 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Acetaminophen
    201 rdf:type schema:DefinedTerm
    202 Ne83a08115ea14172a3f4474f6fb9b877 schema:name readcube_id
    203 schema:value 06019394b6201ebcff88e1c33da67fe72c439de366d2b42a68b819784edbfe6d
    204 rdf:type schema:PropertyValue
    205 Nf8d50722629041f3800af5d52979a38b schema:name dimensions_id
    206 schema:value pub.1092338475
    207 rdf:type schema:PropertyValue
    208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    209 schema:name Medical and Health Sciences
    210 rdf:type schema:DefinedTerm
    211 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Clinical Sciences
    213 rdf:type schema:DefinedTerm
    214 sg:journal.1054337 schema:issn 0031-6970
    215 1432-1041
    216 schema:name European Journal of Clinical Pharmacology
    217 rdf:type schema:Periodical
    218 sg:person.01027656510.58 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
    219 schema:familyName Dear
    220 schema:givenName James W.
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027656510.58
    222 rdf:type schema:Person
    223 sg:person.013646156163.49 schema:affiliation https://www.grid.ac/institutes/grid.39489.3f
    224 schema:familyName Caparrotta
    225 schema:givenName Thomas M.
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013646156163.49
    227 rdf:type schema:Person
    228 sg:person.0664363247.31 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
    229 schema:familyName Antoine
    230 schema:givenName Daniel J.
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664363247.31
    232 rdf:type schema:Person
    233 sg:pub.10.1007/bf00561743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019554449
    234 https://doi.org/10.1007/bf00561743
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/bf00607678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027133220
    237 https://doi.org/10.1007/bf00607678
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/bf00609245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007201329
    240 https://doi.org/10.1007/bf00609245
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/bf00609984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016606009
    243 https://doi.org/10.1007/bf00609984
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/bf00616415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033579096
    246 https://doi.org/10.1007/bf00616415
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/bf00625800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048173482
    249 https://doi.org/10.1007/bf00625800
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/bf01347918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034271481
    252 https://doi.org/10.1007/bf01347918
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/bf02395207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003244760
    255 https://doi.org/10.1007/bf02395207
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/bf03190005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044196718
    258 https://doi.org/10.1007/bf03190005
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s001270170053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047440048
    261 https://doi.org/10.1007/s001270170053
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s00228-003-0608-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043180544
    264 https://doi.org/10.1007/s00228-003-0608-0
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s11095-013-1007-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036906108
    267 https://doi.org/10.1007/s11095-013-1007-6
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s11894-999-0086-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003236915
    270 https://doi.org/10.1007/s11894-999-0086-3
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s40264-012-0013-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019632380
    273 https://doi.org/10.1007/s40264-012-0013-7
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1016/s0009-9236(97)90148-xb schema:sameAs https://app.dimensions.ai/details/publication/pub.1041471051
    276 https://doi.org/10.1016/s0009-9236(97)90148-xb
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/clpt.1982.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053744347
    279 https://doi.org/10.1038/clpt.1982.24
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/clpt.1983.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024024536
    282 https://doi.org/10.1038/clpt.1983.14
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/clpt.2011.176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005200885
    285 https://doi.org/10.1038/clpt.2011.176
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nrgastro.2011.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022657948
    288 https://doi.org/10.1038/nrgastro.2011.22
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/sj.tpj.6500117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018073588
    291 https://doi.org/10.1038/sj.tpj.6500117
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1067/mcp.2000.104736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032350454
    294 https://doi.org/10.1067/mcp.2000.104736
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1067/mcp.2000.106574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021572787
    297 https://doi.org/10.1067/mcp.2000.106574
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1186/2050-6511-15-39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009578278
    300 https://doi.org/10.1186/2050-6511-15-39
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.2165/00003088-198611030-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015838131
    303 https://doi.org/10.2165/00003088-198611030-00006
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.2165/11537240-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016756708
    306 https://doi.org/10.2165/11537240-000000000-00000
    307 rdf:type schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1074763545 schema:CreativeWork
    309 https://app.dimensions.ai/details/publication/pub.1078032015 schema:CreativeWork
    310 https://app.dimensions.ai/details/publication/pub.1080349085 schema:CreativeWork
    311 https://app.dimensions.ai/details/publication/pub.1080564516 schema:CreativeWork
    312 https://app.dimensions.ai/details/publication/pub.1080564519 schema:CreativeWork
    313 https://app.dimensions.ai/details/publication/pub.1082069239 schema:CreativeWork
    314 https://app.dimensions.ai/details/publication/pub.1082176651 schema:CreativeWork
    315 https://app.dimensions.ai/details/publication/pub.1082822613 schema:CreativeWork
    316 https://app.dimensions.ai/details/publication/pub.1083009656 schema:CreativeWork
    317 https://doi.org/10.1001/archinte.161.18.2247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007815105
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1001/archinte.1981.00340030122022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029126625
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1001/archinte.1991.00400060113019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022525531
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1001/archpedi.1984.02140430006003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035015287
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1001/jama.1986.03370190120036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017198518
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1001/jama.1994.03520230055038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027184210
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1001/jama.296.1.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048559401
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1002/0470011815.b2a17103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023251584
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1002/cpt.690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084514176
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1002/cpt1976193284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052750880
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1002/cpt1979264483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005944705
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1002/ejp.621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034605882
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1002/hep.1840220312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006162901
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1002/hep.20300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008913334
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1006/bbrc.1997.7466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018577889
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/0003-9861(88)90592-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040210141
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/0006-2952(93)90437-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046713020
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/0009-2797(94)03587-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022474329
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/0016-5085(92)90106-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052404249
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/0016-5085(95)90758-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040942866
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/0735-6757(88)90044-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048617014
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/j.bcp.2010.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035368758
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/j.clinthera.2006.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044761812
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/j.clinthera.2006.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031328121
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/s0016-5085(00)85930-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040007763
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/s0022-3476(77)80787-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050207171
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/s0022-3476(84)80376-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020701134
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/s0022-3476(97)70359-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051711649
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/s0022-3476(98)70479-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039032818
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/s0031-6989(82)80052-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004203852
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/s0140-6736(71)91125-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052753155
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/s0140-6736(83)92150-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026906907
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1016/s0140-6736(95)91385-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016119455
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1016/s1366-0071(99)80006-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026157108
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1034/j.1399-6576.2001.450104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029257367
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1046/j.1365-2036.2002.01224.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018982256
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1046/j.1365-2125.2000.00167.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021081403
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1046/j.1365-2710.2000.00282.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021412035
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1046/j.1365-2710.2000.00301.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056736484
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1046/j.1365-2796.2003.01097.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005100239
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1046/j.1365-2796.2003.01107.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019942489
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1046/j.1460-9592.1998.00295.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035154821
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1056/nejm199710163371602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013937413
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1080/13556210220120424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014645555
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1081/clt-120002882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029320388
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1081/clt-120030940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019966006
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1093/ageing/19.6.419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059368409
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1093/qjmed/93.6.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052628863
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1093/toxsci/49.2.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031929178
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1097/00005792-199705000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000961352
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1097/00007611-199009000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078784969
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1097/00045391-200007020-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046607284
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1097/00045391-200205000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004590101
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1097/00045391-200501000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049085716
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1097/01.alc.0000108654.77178.03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034991640
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1101/gr.090241.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046419737
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1111/bcp.12362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016978216
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1111/bcp.12831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027939188
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1111/j.0954-6820.1979.tb00728.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050995699
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1111/j.0954-6820.1987.tb10672.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031936769
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1111/j.1365-2044.2007.05340.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036040676
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1111/j.1365-2125.1980.tb01812.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037918584
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1111/j.1365-2125.1984.tb02453.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005847026
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1111/j.1365-2125.1986.tb02953.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033624878
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1111/j.1365-2125.1991.tb03873.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007946846
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1111/j.1365-2125.1991.tb03989.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003321541
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1111/j.1365-2125.1992.tb04112.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006167453
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1111/j.1365-2125.2011.04067.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040303968
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1111/j.1365-2362.1987.tb01242.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007429969
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1111/j.1365-2710.2000.00301.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021808972
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1111/j.1365-2710.2010.01193.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052707562
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1111/j.1365-2796.1992.tb00976.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053042330
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1111/j.1440-1746.1992.tb00926.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016379016
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1111/j.1476-5381.1973.tb08536.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048023151
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1111/j.1532-5415.1976.tb03312.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027118945
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1111/j.1553-2712.2007.00019.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040454613
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1124/dmd.113.053546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025534056
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1124/jpet.112.202010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052248549
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1136/bmj.1.6073.1384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046925347
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1136/bmj.2.6135.478-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1000342220
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1136/bmj.2.6198.1097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040777426
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1136/bmj.c6764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062808070
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1136/bmj.d2218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000536073
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1136/fn.80.1.f59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026614689
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1136/gut.2004.054619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005142326
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1136/gut.29.9.1153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012556582
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1146/annurev.me.35.020184.003045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049694169
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1345/aph.1a035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012558093
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1542/peds.2011-2345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034148324
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1592/phco.27.9.1219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037331272
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.3109/00365518109090500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051276764
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.3109/03602532.2010.527984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004562937
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.3109/07357909609012140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010472509
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.3109/15563650.2014.987397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035760423
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.3810/pgm.2000.01.831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051693754
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.7326/0003-4819-104-3-399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073690815
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.7326/0003-4819-104-3-427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073690820
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.7326/0003-4819-92-4-511_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073737679
    512 rdf:type schema:CreativeWork
    513 https://www.grid.ac/institutes/grid.39489.3f schema:alternateName NHS Lothian
    514 schema:name Speciality Registrar Clinical Pharmacology and Therapeutics, NHS Lothian, Edinburgh, UK
    515 rdf:type schema:Organization
    516 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
    517 schema:name MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    518 University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    519 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...