Reduction in targeted potentially inappropriate medication use in elderly inpatients: a pragmatic randomized controlled trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-10

AUTHORS

Benoit Cossette, Jean-François Éthier, Thomas Joly-Mischlich, Josée Bergeron, Geneviève Ricard, Serge Brazeau, Mathieu Caron, Olivier Germain, Hélène Payette, Janusz Kaczorowski, Mitchell Levine

ABSTRACT

PURPOSE: The use of potentially inappropriate medications (PIMs) in hospitalized older adults is a complex problem, but the use of computerized alert systems (CAS) has shown some potential. The study's objective is to assess the change in PIM use with a CAS-based pharmacist-physician intervention model compared to usual clinical care. METHODS: Pragmatic single-site randomized controlled trial was conducted at a university teaching hospital. Hospitalizations identified with selected Beers or STOPP criteria were randomized to usual clinical care or to the CAS-based pharmacist-physician intervention. The primary outcome was PIM drug cessation or dosage decrease. Clinical relevance of the CAS alerts was assessed. RESULTS: Analyses included 231 patients who had 128 and 126 hospitalizations in the control and intervention groups, respectively. Patients had a mean age of 81, and 60% were female. In the intervention compared to the control group, drug cessation or dosage decrease were more frequent at 48 h post-alert (45.8 vs 15.9%; absolute difference 30.0%; 95%CI 13.8 to 46.1%) and at discharge from the hospital (48.1 vs 27.3%; absolute difference 20.8%; 95%CI 4.6 to 37.0%). In a post hoc analysis of all alerts, regardless of their clinical relevance, the absolute difference in drug cessation or dosage decrease between the intervention and control groups was 16.2% (95%CI 2.9 to 29.6%) at 48 h and 8.0% (95%CI -4.0 to 20.0%) at discharge from the hospital. CONCLUSIONS: In hospitalized older adults, a CAS-based pharmacist-physician intervention, compared to usual clinical care, resulted in significant higher number of drug cessation and dosage reductions for targeted PIMs. More... »

PAGES

1237-1245

References to SciGraph publications

  • 2003-06. Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2013-10. Prevention of Inappropriate Prescribing in Hospitalized Older Patients Using a Computerized Prescription Support System (INTERcheck®) in DRUGS & AGING
  • 2002-04. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
  • 2005-05. Predicting and Preventing Adverse Drug Reactions in the Very Old in DRUGS & AGING
  • 2012-08. Adverse Drug Reactions in a Population of Hospitalized Very Elderly Patients in DRUGS & AGING
  • 2006-01. Impact of Hospitalisation in an Acute Medical Geriatric Unit on Potentially Inappropriate Medication Use in DRUGS & AGING
  • 2012-08. Adverse drug reactions in a population of hospitalized very elderly patients. in DRUGS & AGING
  • 2016-04. A New Computer-Based Tool to Reduce Potentially Inappropriate Prescriptions in Hospitalized Geriatric Patients in DRUGS & AGING
  • 2013-07. Systematic review of anticholinergic risk scales in older adults in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2015-08. A Pharmacist–Physician Intervention Model Using a Computerized Alert System to Reduce High-Risk Medication Use in Elderly Inpatients in DRUGS & AGING
  • 2012-12. Inappropriate prescribing in hospitalised Australian elderly as determined by the STOPP criteria in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
  • 2014-06. The Impact of a Structured Pharmacist Intervention on the Appropriateness of Prescribing in Older Hospitalized Patients in DRUGS & AGING
  • 2016-01. Prevention of Adverse Drug Reactions in Hospitalised Older Patients Using a Software-Supported Structured Pharmacist Intervention: A Cluster Randomised Controlled Trial in DRUGS & AGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00228-017-2293-4

    DOI

    http://dx.doi.org/10.1007/s00228-017-2293-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090740808

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28717929


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