Pharmacokinetics of buccal and intranasal lorazepam in healthy adult volunteers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02

AUTHORS

Mark Anderson, Parag Tambe, Helen Sammons, Hussain Mulla, Richard Cole, Imti Choonara

ABSTRACT

PURPOSE: To investigate the plasma-concentration profile of lorazepam when administered by the intranasal and buccal routes to determine their utility for the treatment of prolonged seizures. METHODS: On two occasions separated by at least 7 days washout, 12 healthy adult male volunteers received 2 mg of lorazepam via the intranasal or buccal route. Blood samples were collected at time periods from 0 to 48 h, and pharmacokinetic parameters were determined. RESULTS: Lorazepam was well absorbed from both administration routes; however, there was a more pronounced lag phase with the buccal route and absorption was more rapid from the intranasal route. CONCLUSIONS: Intranasal lorazepam has more favourable pharmacokinetics than buccal lorazepam when considering the need for the rapid blood concentrations required for seizure termination. Further clinical evaluation of this route is required. More... »

PAGES

155-159

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00228-011-1109-1

DOI

http://dx.doi.org/10.1007/s00228-011-1109-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028981374

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21837394


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