Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-05

AUTHORS

Mikko Kuoppamäki, Kirsi Korpela, Reijo Marttila, Valtteri Kaasinen, Päivi Hartikainen, Jukka Lyytinen, Seppo Kaakkola, Jutta Hänninen, Eliisa Löyttyniemi, Marita Kailajärvi, Päivi Ruokoniemi, Juha Ellmén

ABSTRACT

OBJECTIVES: To compare plasma levodopa concentrations after repeated doses of levodopa/carbidopa/entacapone (LCE) and levodopa/carbidopa (LC). METHODS: Open-label, randomized, two-period, active-controlled, cross-over study with four dosing regimens: groups I and II (healthy volunteers and Parkinson's disease patients) received levodopa 100 mg or 150 mg four times daily, respectively, and groups III and IV (healthy volunteers) received the same strengths of levodopa five times daily. Pharmacokinetic (PK) parameters determined for levodopa included Cmin, Cmax, Cmax - Cmin, AUC, t(1/2), and tmax. RESULTS: In healthy volunteers and PD patients, mean trough levels (Cmin), Cmax, and AUC of levodopa were, in general, significantly higher during LCE compared to LC administration. Compared to Cmin, Cmax, and AUC, differences between the treatments in variability of levodopa concentrations (Cmax - Cmin) were less consistent. CONCLUSIONS: The present results on the differences in levodopa PK between LCE and LC provide a basis to evaluate the relationship of levodopa PK and the induction of motor complications in an on-going study in early Parkinson's disease using similar dosing regimens. More... »

PAGES

443-455

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00228-009-0622-y

DOI

http://dx.doi.org/10.1007/s00228-009-0622-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035778893

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19229530


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