CYP3A5 *1 allele associated with tacrolimus trough concentrations but not subclinical acute rejection or chronic allograft nephropathy in Japanese renal ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01-06

AUTHORS

Shigeru Satoh, Mitsuru Saito, Takamitsu Inoue, Hideaki Kagaya, Masatomo Miura, Kazuyuki Inoue, Atsushi Komatsuda, Norihiko Tsuchiya, Toshio Suzuki, Tomonori Habuchi

ABSTRACT

PurposeWe assessed reported associations of CYP3A5 *1 allele with a delay in achieving target tacrolimus concentrations, and occurrence of biopsy-confirmed subclinical acute rejection (SAR) and chronic allograft nephropathy (CAN) in Japanese subjects.MethodsForty-one renal allograft recipients were studied. The targeted tacrolimus trough concentrations were 20–25 ng/mL up to 2 weeks post-transplantation, 10–15 ng/mL up to 6 weeks, and 5–10 ng/mL thereafter. At 1 month and 1 year post-transplantation, allograft biopsies were performed.ResultsThe CYP3A5 *1/*1 + *1/*3 (expresser) and *3/*3 (nonexpresser) alleles were detected in 19 and 22 patients, respectively. Although the mean trough concentrations were lower in CYP3A5 expressers than nonexpressers for the first 3 weeks, no difference in frequency of SAR among CYP3A5 genotypes was found. The mean trough concentrations were lower from 8 to 12 months post-transplantation, and the frequency of CAN was lower in CYP3A5 expressers.ConclusionsIn contrast to the previous reports, the CYP3A5 *1 allele was not associated with the frequency of SAR or CAN, suggesting that further studies of different immunosuppressive strategies using tacrolimus are needed to confirm the adequate dosing and concentration of tacrolimus for each CYP3A5 genotype. More... »

PAGES

473

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00228-008-0606-3

DOI

http://dx.doi.org/10.1007/s00228-008-0606-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048804676

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19125240


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