Clinical pharmacokinetics of penicillins in the neonate: a review of the literature View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

G. M. Pacifici, J. Labatia, H. Mulla, I. Choonara

ABSTRACT

BACKGROUND: Sepsis is common in neonates and a major cause of morbidity and mortality. Sixty percent of preterm neonates receive at least one antibiotic during the first week of life, with penicillins being the most frequently administered antibiotics. The clearance (Cl), serum half-life (t((1/2))) and volume of distribution (Vd) of penicillins are different in the neonate than in the adult. As such, the pharmacokinetics of penicillins need be studied in neonates in order to optimise therapy in this age class with these drugs. OBJECTIVES: The aim of this study was to review the published data on the pharmacokinetics of penicillins in the neonate in order to provide a critical analysis of the literature and, consequently, a useful tool in the hands of the physician. METHODS: The bibliographic search was performed electronically using the PubMed and EMBASE databases as search engines. An initial search was performed with the keywords "pharmacokinetics", "penicillins" and "neonates". Secondly, other searches were performed using the keywords "pharmacokinetics" and "neonates", followed by the name of a single antibiotic. The search included articles up to 2007. RESULTS: There have been few pharmacokinetic studies on the use of penicillins in neonates. The results from those few studies that have been carried out suggest that the Cl is reduced and t((1/2)) prolonged in the neonate as compared with the more mature infant. There is little variation in Vd during the first week of life. In the premature neonate, Cl is reduced compared to the full-term infant. As postnatal age proceeds, the Cl of penicillins increases. CONCLUSIONS: More pharmacokinetic studies are required to provide a sound scientific basis for planning a dosage regimen with penicillins in the neonate. More... »

PAGES

191-198

References to SciGraph publications

  • 2004-04. Antimicrobial pharmacodynamics: critical interactions of 'bug and drug' in NATURE REVIEWS MICROBIOLOGY
  • 1987-07. Pharmacokinetics of free and total flucloxacilin in newborn infants in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1990-10. Clinical Pharmacokinetics of Antibacterial Drugs in Neonates in CLINICAL PHARMACOKINETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00228-008-0562-y

    DOI

    http://dx.doi.org/10.1007/s00228-008-0562-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052908872

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18810399


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        "description": "BACKGROUND: Sepsis is common in neonates and a major cause of morbidity and mortality. Sixty percent of preterm neonates receive at least one antibiotic during the first week of life, with penicillins being the most frequently administered antibiotics. The clearance (Cl), serum half-life (t((1/2))) and volume of distribution (Vd) of penicillins are different in the neonate than in the adult. As such, the pharmacokinetics of penicillins need be studied in neonates in order to optimise therapy in this age class with these drugs.\nOBJECTIVES: The aim of this study was to review the published data on the pharmacokinetics of penicillins in the neonate in order to provide a critical analysis of the literature and, consequently, a useful tool in the hands of the physician.\nMETHODS: The bibliographic search was performed electronically using the PubMed and EMBASE databases as search engines. An initial search was performed with the keywords \"pharmacokinetics\", \"penicillins\" and \"neonates\". Secondly, other searches were performed using the keywords \"pharmacokinetics\" and \"neonates\", followed by the name of a single antibiotic. The search included articles up to 2007.\nRESULTS: There have been few pharmacokinetic studies on the use of penicillins in neonates. The results from those few studies that have been carried out suggest that the Cl is reduced and t((1/2)) prolonged in the neonate as compared with the more mature infant. There is little variation in Vd during the first week of life. In the premature neonate, Cl is reduced compared to the full-term infant. As postnatal age proceeds, the Cl of penicillins increases.\nCONCLUSIONS: More pharmacokinetic studies are required to provide a sound scientific basis for planning a dosage regimen with penicillins in the neonate.", 
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