Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-03-22

AUTHORS

Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

ABSTRACT

Current treatment options for osteoporosis primarily involve pharmacotherapies, but they are often accompanied by undesirable side effects. Utilization of mechanical stress which can noninvasively induce bone formation has been suggested as an alternative to conventional treatments. Here, we examined the efficacy of mechanical stress induced by electrical stimulation, radial extracorporeal shock waves, and ultrasound for estrogen-deficient osteoporosis. Female Wistar rats were divided into following five groups: sham-operated group, untreated after ovariectomy, and treated with electrical stimulation, radial extracorporeal shock wave, or ultrasound starting at 8 weeks after ovariectomy for 4 weeks. Trabecular bone architecture of the femur was assessed by micro-CT and its biomechanical properties were obtained by mechanical testing. The femurs were further evaluated by histochemical, immunohistochemical, and real-time PCR analyses. Radial extracorporeal shock wave and ultrasound treatment improved trabecular bone microarchitecture and bone strength in osteoporotic rats, but not electrical stimulation. The shock wave decreased osteoclast activity and RANKL expression. The exposure of ultrasound increased osteoblast activity and β-catenin-positive cells, and they decreased sclerostin-positive osteocytes. These findings suggest that mechanical stress induced by radial extracorporeal shock wave and ultrasound can improve estrogen-deficient bone loss and bone fragility through promoted bone formation or attenuated bone resorption. More... »

PAGES

215-229

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00223-021-00831-6

DOI

http://dx.doi.org/10.1007/s00223-021-00831-6

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33751141


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