A Novel microCT Method for Bone and Marrow Adipose Tissue Alignment Identifies Key Differences Between Mandible and Tibia in Rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01-30

AUTHORS

Xavier Coutel, Cécile Olejnik, Pierre Marchandise, Jérôme Delattre, Hélène Béhal, Greet Kerckhofs, Guillaume Penel

ABSTRACT

Bone homeostasis is influenced by the bone marrow adipose tissue (BMAT). BMAT distribution varies from one anatomical location in the skeleton to another. We developed an advanced microfocus computed tomography imaging and analysis protocol that allows accurate alignment of both the BMAT distribution and bone micro-architecture as well as calculation of the distance of the BMAT adipocytes from the bone surface. Using this protocol, we detected a different spatial BMAT distribution between the rat tibia and mandible: in the proximal metaphysis of the tibia a large amount of BMAT (~ 20% of the total BMAT) was located close to the bone surface (< 20 µm), whereas in the alveolar ridge ~ 30% of the total BMAT was located between 40 and 60 µm from the bone surface. In the alveolar ridge of rats, the trabecular bone volume was 48.3% higher compared to the proximal metaphysis of the tibia (p < 0.0001) and the percentage of adiposity determined to the relative marrow volume was lower (1.5%) compared to the proximal metaphysis of the tibia (9%, p = 0.0002). Interestingly, in the tibia a negative correlation was found between the percentage of adiposity in the total volume and the trabecular thickness (r =− 0.74, p = 0.037). The present study highlights that in comparison to tibial proximal metaphysis, the mandibular bone exhibits a massive trabecular network and a low BMAT content with almost no contact with the bone surface. These findings are of great interest because of the importance of the fat–bone interaction and its potential relevance to several resorptive bone diseases. More... »

PAGES

189-197

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00223-018-0397-1

DOI

http://dx.doi.org/10.1007/s00223-018-0397-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100691827

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29383407


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adiposity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Density", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeostasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Image Processing, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imaging, Three-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mandible", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osmium Tetroxide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tibia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Ray Microtomography", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.503422.2", 
          "name": [
            "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coutel", 
        "givenName": "Xavier", 
        "id": "sg:person.014276063255.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014276063255.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.503422.2", 
          "name": [
            "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olejnik", 
        "givenName": "C\u00e9cile", 
        "id": "sg:person.01302417734.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302417734.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.503422.2", 
          "name": [
            "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchandise", 
        "givenName": "Pierre", 
        "id": "sg:person.07763333455.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07763333455.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.503422.2", 
          "name": [
            "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delattre", 
        "givenName": "J\u00e9r\u00f4me", 
        "id": "sg:person.013513000144.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013513000144.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Univ. Lille, CHU Lille, EA 2694 - Sant\u00e9 publique: \u00e9pid\u00e9miologie et qualit\u00e9 des soins, Unit\u00e9 de M\u00e9thodologie et Biostatistiques, 59000, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "Univ. Lille, CHU Lille, EA 2694 - Sant\u00e9 publique: \u00e9pid\u00e9miologie et qualit\u00e9 des soins, Unit\u00e9 de M\u00e9thodologie et Biostatistiques, 59000, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00e9hal", 
        "givenName": "H\u00e9l\u00e8ne", 
        "id": "sg:person.01216301103.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216301103.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Department of Development and Regeneration, Skeletal Biology and Engineering Center, KU Leuven, Leuven, Belgium", 
            "Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerckhofs", 
        "givenName": "Greet", 
        "id": "sg:person.01054642661.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054642661.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.503422.2", 
          "name": [
            "Univ.Lille, Univ. Littoral C\u00f4te d\u2019Opale, EA 4490 - PMOI \u2013 Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Penel", 
        "givenName": "Guillaume", 
        "id": "sg:person.0576716050.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576716050.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00276-012-0943-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006217614", 
          "https://doi.org/10.1007/s00276-012-0943-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00318051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028620659", 
          "https://doi.org/10.1007/bf00318051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10266-010-0153-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001308281", 
          "https://doi.org/10.1007/s10266-010-0153-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms8808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003648329", 
          "https://doi.org/10.1038/ncomms8808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-016-0168-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040196309", 
          "https://doi.org/10.1007/s00223-016-0168-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1011513223894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018871641", 
          "https://doi.org/10.1023/a:1011513223894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011517403", 
          "https://doi.org/10.1038/nature08099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02554882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020104969", 
          "https://doi.org/10.1007/bf02554882"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-01-30", 
    "datePublishedReg": "2018-01-30", 
    "description": "Bone homeostasis is influenced by the bone marrow adipose tissue (BMAT). BMAT distribution varies from one anatomical location in the skeleton to another. We developed an advanced microfocus computed tomography imaging and analysis protocol that allows accurate alignment of both the BMAT distribution and bone micro-architecture as well as calculation of the distance of the BMAT adipocytes from the bone surface. Using this protocol, we detected a different spatial BMAT distribution between the rat tibia and mandible: in the proximal metaphysis of the tibia a large amount of BMAT (~\u200920% of the total BMAT) was located close to the bone surface (<\u200920\u00a0\u00b5m), whereas in the alveolar ridge\u2009~\u200930% of the total BMAT was located between 40 and 60\u00a0\u00b5m from the bone surface. In the alveolar ridge of rats, the trabecular bone volume was 48.3% higher compared to the proximal metaphysis of the tibia (p\u2009<\u20090.0001) and the percentage of adiposity determined to the relative marrow volume was lower (1.5%) compared to the proximal metaphysis of the tibia (9%, p\u2009=\u20090.0002). Interestingly, in the tibia a negative correlation was found between the percentage of adiposity in the total volume and the trabecular thickness (r\u2009=\u2212\u20090.74, p\u2009=\u20090.037). The present study highlights that in comparison to tibial proximal metaphysis, the mandibular bone exhibits a massive trabecular network and a low BMAT content with almost no contact with the bone surface. These findings are of great interest because of the importance of the fat\u2013bone interaction and its potential relevance to several resorptive bone diseases.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00223-018-0397-1", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8498387", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1089641", 
        "issn": [
          "0171-967X", 
          "1432-0827"
        ], 
        "name": "Calcified Tissue International", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "103"
      }
    ], 
    "keywords": [
      "bone marrow adipose tissue", 
      "percentage of adiposity", 
      "proximal metaphysis", 
      "alveolar ridge", 
      "bone surface", 
      "fat-bone interactions", 
      "tibial proximal metaphysis", 
      "resorptive bone diseases", 
      "trabecular bone volume", 
      "bone disease", 
      "adipose tissue", 
      "bone homeostasis", 
      "bone volume", 
      "anatomical location", 
      "marrow volume", 
      "trabecular thickness", 
      "metaphysis", 
      "mandibular bone", 
      "tomography imaging", 
      "tibia", 
      "surface", 
      "adiposity", 
      "rat tibia", 
      "rats", 
      "bone", 
      "microCT method", 
      "present study", 
      "trabecular network", 
      "potential relevance", 
      "mandible", 
      "negative correlation", 
      "tissue alignment", 
      "accurate alignment", 
      "great interest", 
      "total volume", 
      "thickness", 
      "large amount", 
      "disease", 
      "percentage", 
      "distribution", 
      "homeostasis", 
      "microfocus", 
      "tissue", 
      "volume", 
      "protocol", 
      "imaging", 
      "findings", 
      "analysis protocol", 
      "contact", 
      "alignment", 
      "calculations", 
      "differences", 
      "study", 
      "method", 
      "ridge", 
      "correlation", 
      "relevance", 
      "amount", 
      "location", 
      "content", 
      "key differences", 
      "network", 
      "comparison", 
      "distance", 
      "importance", 
      "interest", 
      "skeleton", 
      "interaction"
    ], 
    "name": "A Novel microCT Method for Bone and Marrow Adipose Tissue Alignment Identifies Key Differences Between Mandible and Tibia in Rats", 
    "pagination": "189-197", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100691827"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00223-018-0397-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29383407"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00223-018-0397-1", 
      "https://app.dimensions.ai/details/publication/pub.1100691827"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_762.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00223-018-0397-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00223-018-0397-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00223-018-0397-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00223-018-0397-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00223-018-0397-1'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      21 PREDICATES      117 URIs      101 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00223-018-0397-1 schema:about N0b46d3dae4fd4d93bc1fba77cac8927f
2 N109215904e904e4bb31e8ef978ac1d83
3 N11d73915c6f1484b92c6b252df99c42d
4 N18c1f2152a3840369f31809644e6f2df
5 N31d9b8cb202f4c839954798feaab19a5
6 N36c0f70782304f22bc5643088d7403f4
7 N396c5c8c5bb24a878ea75ef17e9aa038
8 N4a43055672d04cc3a6124386d4b7ac41
9 N6415b11afed44f57b409d924182b7ca2
10 N65eafc51cb1545b6958471436e8c8b31
11 Na33080ffc82d490281939a0158a6ac3b
12 Na4f2a2c2b9d64a8986a881f6e48f2795
13 Nb3c9a2a161b04cb38af95055a278896c
14 Ncc6ed7b9e03f475cb513f8bbed5d8fc1
15 Nd42fc4218f104f3ea444a6ef2a618c5c
16 Ne3a5d2404d4747b688814fbb5eb69320
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Ncf894d180d0640f5b2ee3069d0ca5d7a
20 schema:citation sg:pub.10.1007/bf00318051
21 sg:pub.10.1007/bf02554882
22 sg:pub.10.1007/s00223-016-0168-9
23 sg:pub.10.1007/s00276-012-0943-x
24 sg:pub.10.1007/s10266-010-0153-0
25 sg:pub.10.1023/a:1011513223894
26 sg:pub.10.1038/nature08099
27 sg:pub.10.1038/ncomms8808
28 schema:datePublished 2018-01-30
29 schema:datePublishedReg 2018-01-30
30 schema:description Bone homeostasis is influenced by the bone marrow adipose tissue (BMAT). BMAT distribution varies from one anatomical location in the skeleton to another. We developed an advanced microfocus computed tomography imaging and analysis protocol that allows accurate alignment of both the BMAT distribution and bone micro-architecture as well as calculation of the distance of the BMAT adipocytes from the bone surface. Using this protocol, we detected a different spatial BMAT distribution between the rat tibia and mandible: in the proximal metaphysis of the tibia a large amount of BMAT (~ 20% of the total BMAT) was located close to the bone surface (< 20 µm), whereas in the alveolar ridge ~ 30% of the total BMAT was located between 40 and 60 µm from the bone surface. In the alveolar ridge of rats, the trabecular bone volume was 48.3% higher compared to the proximal metaphysis of the tibia (p < 0.0001) and the percentage of adiposity determined to the relative marrow volume was lower (1.5%) compared to the proximal metaphysis of the tibia (9%, p = 0.0002). Interestingly, in the tibia a negative correlation was found between the percentage of adiposity in the total volume and the trabecular thickness (r =− 0.74, p = 0.037). The present study highlights that in comparison to tibial proximal metaphysis, the mandibular bone exhibits a massive trabecular network and a low BMAT content with almost no contact with the bone surface. These findings are of great interest because of the importance of the fat–bone interaction and its potential relevance to several resorptive bone diseases.
31 schema:genre article
32 schema:isAccessibleForFree false
33 schema:isPartOf N0f1314e88eb649e0881ddcf8de6a19f2
34 Nb69b399ee7704cafa3bae8b6e6f6ae95
35 sg:journal.1089641
36 schema:keywords accurate alignment
37 adipose tissue
38 adiposity
39 alignment
40 alveolar ridge
41 amount
42 analysis protocol
43 anatomical location
44 bone
45 bone disease
46 bone homeostasis
47 bone marrow adipose tissue
48 bone surface
49 bone volume
50 calculations
51 comparison
52 contact
53 content
54 correlation
55 differences
56 disease
57 distance
58 distribution
59 fat-bone interactions
60 findings
61 great interest
62 homeostasis
63 imaging
64 importance
65 interaction
66 interest
67 key differences
68 large amount
69 location
70 mandible
71 mandibular bone
72 marrow volume
73 metaphysis
74 method
75 microCT method
76 microfocus
77 negative correlation
78 network
79 percentage
80 percentage of adiposity
81 potential relevance
82 present study
83 protocol
84 proximal metaphysis
85 rat tibia
86 rats
87 relevance
88 resorptive bone diseases
89 ridge
90 skeleton
91 study
92 surface
93 thickness
94 tibia
95 tibial proximal metaphysis
96 tissue
97 tissue alignment
98 tomography imaging
99 total volume
100 trabecular bone volume
101 trabecular network
102 trabecular thickness
103 volume
104 schema:name A Novel microCT Method for Bone and Marrow Adipose Tissue Alignment Identifies Key Differences Between Mandible and Tibia in Rats
105 schema:pagination 189-197
106 schema:productId N8cc51afde5bc44549e50433ff5227449
107 Na226d5e30119424fbc4188b8e8aea5ef
108 Ndefdce74105746c88bbdbf663f7441d7
109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100691827
110 https://doi.org/10.1007/s00223-018-0397-1
111 schema:sdDatePublished 2022-11-24T21:03
112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
113 schema:sdPublisher Ne8931129ef374c86a09802091a73836c
114 schema:url https://doi.org/10.1007/s00223-018-0397-1
115 sgo:license sg:explorer/license/
116 sgo:sdDataset articles
117 rdf:type schema:ScholarlyArticle
118 N02d4a113ac124760965fc4d44044edef rdf:first sg:person.013513000144.25
119 rdf:rest Nb5147ff04acc43838312f78333af160d
120 N0b46d3dae4fd4d93bc1fba77cac8927f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Tibia
122 rdf:type schema:DefinedTerm
123 N0f1314e88eb649e0881ddcf8de6a19f2 schema:volumeNumber 103
124 rdf:type schema:PublicationVolume
125 N109215904e904e4bb31e8ef978ac1d83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Rats, Sprague-Dawley
127 rdf:type schema:DefinedTerm
128 N11d73915c6f1484b92c6b252df99c42d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mandible
130 rdf:type schema:DefinedTerm
131 N15e0f879a223425cbdacefdb695ba9bd rdf:first sg:person.01054642661.26
132 rdf:rest Ndf9d297b1c684d7faa512e348b4a41f2
133 N18c1f2152a3840369f31809644e6f2df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name X-Ray Microtomography
135 rdf:type schema:DefinedTerm
136 N31d9b8cb202f4c839954798feaab19a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Osmium Tetroxide
138 rdf:type schema:DefinedTerm
139 N36c0f70782304f22bc5643088d7403f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Rats
141 rdf:type schema:DefinedTerm
142 N396c5c8c5bb24a878ea75ef17e9aa038 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Female
144 rdf:type schema:DefinedTerm
145 N3bf8234b9b404f1083043ba46cce1e90 rdf:first sg:person.01302417734.36
146 rdf:rest Nec738116e58b4f71a87ab154f2dde4c2
147 N4a43055672d04cc3a6124386d4b7ac41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adiposity
149 rdf:type schema:DefinedTerm
150 N6415b11afed44f57b409d924182b7ca2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Bone Marrow
152 rdf:type schema:DefinedTerm
153 N65eafc51cb1545b6958471436e8c8b31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Imaging, Three-Dimensional
155 rdf:type schema:DefinedTerm
156 N8cc51afde5bc44549e50433ff5227449 schema:name dimensions_id
157 schema:value pub.1100691827
158 rdf:type schema:PropertyValue
159 Na226d5e30119424fbc4188b8e8aea5ef schema:name pubmed_id
160 schema:value 29383407
161 rdf:type schema:PropertyValue
162 Na33080ffc82d490281939a0158a6ac3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adipocytes
164 rdf:type schema:DefinedTerm
165 Na4f2a2c2b9d64a8986a881f6e48f2795 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 Nb3c9a2a161b04cb38af95055a278896c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Homeostasis
170 rdf:type schema:DefinedTerm
171 Nb5147ff04acc43838312f78333af160d rdf:first sg:person.01216301103.45
172 rdf:rest N15e0f879a223425cbdacefdb695ba9bd
173 Nb69b399ee7704cafa3bae8b6e6f6ae95 schema:issueNumber 2
174 rdf:type schema:PublicationIssue
175 Ncc6ed7b9e03f475cb513f8bbed5d8fc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Adipose Tissue
177 rdf:type schema:DefinedTerm
178 Ncf894d180d0640f5b2ee3069d0ca5d7a rdf:first sg:person.014276063255.35
179 rdf:rest N3bf8234b9b404f1083043ba46cce1e90
180 Nd42fc4218f104f3ea444a6ef2a618c5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Bone Density
182 rdf:type schema:DefinedTerm
183 Ndefdce74105746c88bbdbf663f7441d7 schema:name doi
184 schema:value 10.1007/s00223-018-0397-1
185 rdf:type schema:PropertyValue
186 Ndf9d297b1c684d7faa512e348b4a41f2 rdf:first sg:person.0576716050.90
187 rdf:rest rdf:nil
188 Ne3a5d2404d4747b688814fbb5eb69320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Image Processing, Computer-Assisted
190 rdf:type schema:DefinedTerm
191 Ne8931129ef374c86a09802091a73836c schema:name Springer Nature - SN SciGraph project
192 rdf:type schema:Organization
193 Nec738116e58b4f71a87ab154f2dde4c2 rdf:first sg:person.07763333455.50
194 rdf:rest N02d4a113ac124760965fc4d44044edef
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
199 schema:name Clinical Sciences
200 rdf:type schema:DefinedTerm
201 sg:grant.8498387 http://pending.schema.org/fundedItem sg:pub.10.1007/s00223-018-0397-1
202 rdf:type schema:MonetaryGrant
203 sg:journal.1089641 schema:issn 0171-967X
204 1432-0827
205 schema:name Calcified Tissue International
206 schema:publisher Springer Nature
207 rdf:type schema:Periodical
208 sg:person.01054642661.26 schema:affiliation grid-institutes:grid.5596.f
209 schema:familyName Kerckhofs
210 schema:givenName Greet
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054642661.26
212 rdf:type schema:Person
213 sg:person.01216301103.45 schema:affiliation grid-institutes:grid.410463.4
214 schema:familyName Béhal
215 schema:givenName Hélène
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216301103.45
217 rdf:type schema:Person
218 sg:person.01302417734.36 schema:affiliation grid-institutes:grid.503422.2
219 schema:familyName Olejnik
220 schema:givenName Cécile
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302417734.36
222 rdf:type schema:Person
223 sg:person.013513000144.25 schema:affiliation grid-institutes:grid.503422.2
224 schema:familyName Delattre
225 schema:givenName Jérôme
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013513000144.25
227 rdf:type schema:Person
228 sg:person.014276063255.35 schema:affiliation grid-institutes:grid.503422.2
229 schema:familyName Coutel
230 schema:givenName Xavier
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014276063255.35
232 rdf:type schema:Person
233 sg:person.0576716050.90 schema:affiliation grid-institutes:grid.503422.2
234 schema:familyName Penel
235 schema:givenName Guillaume
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576716050.90
237 rdf:type schema:Person
238 sg:person.07763333455.50 schema:affiliation grid-institutes:grid.503422.2
239 schema:familyName Marchandise
240 schema:givenName Pierre
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07763333455.50
242 rdf:type schema:Person
243 sg:pub.10.1007/bf00318051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028620659
244 https://doi.org/10.1007/bf00318051
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/bf02554882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020104969
247 https://doi.org/10.1007/bf02554882
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/s00223-016-0168-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040196309
250 https://doi.org/10.1007/s00223-016-0168-9
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/s00276-012-0943-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006217614
253 https://doi.org/10.1007/s00276-012-0943-x
254 rdf:type schema:CreativeWork
255 sg:pub.10.1007/s10266-010-0153-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001308281
256 https://doi.org/10.1007/s10266-010-0153-0
257 rdf:type schema:CreativeWork
258 sg:pub.10.1023/a:1011513223894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018871641
259 https://doi.org/10.1023/a:1011513223894
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nature08099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011517403
262 https://doi.org/10.1038/nature08099
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/ncomms8808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003648329
265 https://doi.org/10.1038/ncomms8808
266 rdf:type schema:CreativeWork
267 grid-institutes:grid.410463.4 schema:alternateName Univ. Lille, CHU Lille, EA 2694 - Santé publique: épidémiologie et qualité des soins, Unité de Méthodologie et Biostatistiques, 59000, Lille, France
268 schema:name Univ. Lille, CHU Lille, EA 2694 - Santé publique: épidémiologie et qualité des soins, Unité de Méthodologie et Biostatistiques, 59000, Lille, France
269 rdf:type schema:Organization
270 grid-institutes:grid.503422.2 schema:alternateName Univ.Lille, Univ. Littoral Côte d’Opale, EA 4490 - PMOI – Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France
271 schema:name Univ.Lille, Univ. Littoral Côte d’Opale, EA 4490 - PMOI – Physiopathologie des Maladies Osseuses Inflammatoires, 59000, Lille, France
272 rdf:type schema:Organization
273 grid-institutes:grid.5596.f schema:alternateName Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
274 schema:name Department of Development and Regeneration, Skeletal Biology and Engineering Center, KU Leuven, Leuven, Belgium
275 Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...