Studying Variations in Bone Composition at Nano-Scale Resolution: A Preliminary Report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08-26

AUTHORS

Samuel Gourion-Arsiquaud, Curtis Marcott, Qichi Hu, Adele L. Boskey

ABSTRACT

Bone has a hierarchical structure extending from the micrometer to the nanometer scale. We report here the first analysis of non-human primate osteonal bone obtained using a spectrometer coupled to an AFM microscope (AFM-IR), with a resolution of 50–100 nm. Average spectra correspond to those observed with conventional FTIR spectroscopy. The following validated FTIR parameters were calculated based on intensities observed in scans covering ~60 µm from the osteon center: mineral content (1030/1660 cm−1), crystallinity (1030/1020 cm−1), collagen maturity (1660/1690 cm−1), and acid phosphate content (1128/1096 cm−1). A repeating pattern was found in most of these calculated IR parameters corresponding to the reported inter- and intra-lamellar spacing in human bone, indicating that AFM-IR measurements will be able to provide novel compositional information on the variation in bone at the nanometer level. More... »

PAGES

413-418

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00223-014-9909-9

DOI

http://dx.doi.org/10.1007/s00223-014-9909-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017755189

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25155443


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