Ontology type: schema:ScholarlyArticle
2012-10-23
AUTHORSYohann Bala, Joseph Kohles, Robert R. Recker, Georges Boivin
ABSTRACTPostmenopausal osteoporotic (PMOP) women treated with ibandronate had higher bone mineral density, lower bone turnover, and decreased incidence of new vertebral fractures. The aim of this study was to investigate the effect of daily or intermittent oral ibandronate on the degree of mineralization (DMB) of bone and microhardness (Hv) at the bone tissue and bone structural unit (BSU) levels. A total of 110 iliac biopsies were taken from patients treated for 22 or 34 months with an oral placebo (n = 36), 2.5 mg daily oral ibandronate (n = 40), or 20 mg intermittent oral ibandronate (n = 34). These regimens provide annual cumulative exposures (ACEs) that are about half of the therapeutic doses currently licensed for PMOP women. DMB and Hv were measured at the global level (i.e., cortical or cancellous) and the focal level (i.e., BSU). At the global level, DMB and its distribution were not significantly different from placebo after 22 and 34 months of treatment. Hv was significantly higher in the cortical, cancellous, and total bone after 22 and 34 months of ibandronate versus placebo for both regimens. At the focal level, DMB and Hv, measured simultaneously in 3,760 BSUs, were significantly and positively correlated in all groups (r = 0.59–0.65, p < 0.0001). However, analysis of covariance highlighted the differences in the y intercepts of the linear regressions of the placebo- and ibandronate-treated groups. We infer that a low ACE of oral ibandronate altered the bone micromechanical properties irrespective of changes in secondary mineralization. More... »
PAGES6-14
http://scigraph.springernature.com/pub.10.1007/s00223-012-9658-6
DOIhttp://dx.doi.org/10.1007/s00223-012-9658-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1036510668
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23090678
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Administration, Oral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biopsy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Density",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Density Conservation Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diphosphonates",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Double-Blind Method",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fractures, Bone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ibandronic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Osteoporosis, Postmenopausal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Placebos",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Regression Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reproducibility of Results",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Universit\u00e9 de Lyon, UMR 1033, 69008, Lyon, France",
"id": "http://www.grid.ac/institutes/grid.25697.3f",
"name": [
"INSERM UMR 1033 Equipe \u201cQualit\u00e9 Osseuse et Marqueurs Biologiques\u201d, Facult\u00e9 de M\u00e9decine Lyon Est, Claude Bernard (Domaine Laennec), Universit\u00e9 de Lyon, 7\u201311 rue Guillaume Paradin, 69372, Lyon Cedex 08, France",
"Universit\u00e9 de Lyon, UMR 1033, 69008, Lyon, France"
],
"type": "Organization"
},
"familyName": "Bala",
"givenName": "Yohann",
"id": "sg:person.01260243176.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260243176.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hoffmann-LaRoche, 07110, Nutley, NJ, USA",
"id": "http://www.grid.ac/institutes/grid.418158.1",
"name": [
"Hoffmann-LaRoche, 07110, Nutley, NJ, USA"
],
"type": "Organization"
},
"familyName": "Kohles",
"givenName": "Joseph",
"id": "sg:person.01150513510.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150513510.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center, 68131, Omaha, NE, USA",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Osteoporosis Research Center, 68131, Omaha, NE, USA"
],
"type": "Organization"
},
"familyName": "Recker",
"givenName": "Robert R.",
"id": "sg:person.016325222544.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016325222544.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universit\u00e9 de Lyon, UMR 1033, 69008, Lyon, France",
"id": "http://www.grid.ac/institutes/grid.25697.3f",
"name": [
"INSERM UMR 1033 Equipe \u201cQualit\u00e9 Osseuse et Marqueurs Biologiques\u201d, Facult\u00e9 de M\u00e9decine Lyon Est, Claude Bernard (Domaine Laennec), Universit\u00e9 de Lyon, 7\u201311 rue Guillaume Paradin, 69372, Lyon Cedex 08, France",
"Universit\u00e9 de Lyon, UMR 1033, 69008, Lyon, France"
],
"type": "Organization"
},
"familyName": "Boivin",
"givenName": "Georges",
"id": "sg:person.01270330331.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270330331.76"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00198-007-0540-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051377661",
"https://doi.org/10.1007/s00198-007-0540-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00198-005-2035-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041631602",
"https://doi.org/10.1007/s00198-005-2035-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1018671823059",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017861302",
"https://doi.org/10.1023/a:1018671823059"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00198-007-0462-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029822466",
"https://doi.org/10.1007/s00198-007-0462-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00198-003-1530-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045100855",
"https://doi.org/10.1007/s00198-003-1530-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1557/jmr.1999.0490",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053186687",
"https://doi.org/10.1557/jmr.1999.0490"
],
"type": "CreativeWork"
}
],
"datePublished": "2012-10-23",
"datePublishedReg": "2012-10-23",
"description": "Postmenopausal osteoporotic (PMOP) women treated with ibandronate had higher bone mineral density, lower bone turnover, and decreased incidence of new vertebral fractures. The aim of this study was to investigate the effect of daily or intermittent oral ibandronate on the degree of mineralization (DMB) of bone and microhardness (Hv) at the bone tissue and bone structural unit (BSU) levels. A total of 110 iliac biopsies were taken from patients treated for 22 or 34\u00a0months with an oral placebo (n\u00a0=\u00a036), 2.5\u00a0mg daily oral ibandronate (n\u00a0=\u00a040), or 20\u00a0mg intermittent oral ibandronate (n\u00a0=\u00a034). These regimens provide annual cumulative exposures (ACEs) that are about half of the therapeutic doses currently licensed for PMOP women. DMB and Hv were measured at the global level (i.e., cortical or cancellous) and the focal level (i.e., BSU). At the global level, DMB and its distribution were not significantly different from placebo after 22 and 34\u00a0months of treatment. Hv was significantly higher in the cortical, cancellous, and total bone after 22 and 34\u00a0months of ibandronate versus placebo for both regimens. At the focal level, DMB and Hv, measured simultaneously in 3,760 BSUs, were significantly and positively correlated in all groups (r\u00a0=\u00a00.59\u20130.65, p\u00a0<\u00a00.0001). However, analysis of covariance highlighted the differences in the y intercepts of the linear regressions of the placebo- and ibandronate-treated groups. We infer that a low ACE of oral ibandronate altered the bone micromechanical properties irrespective of changes in secondary mineralization.",
"genre": "article",
"id": "sg:pub.10.1007/s00223-012-9658-6",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1089641",
"issn": [
"0171-967X",
"1432-0827"
],
"name": "Calcified Tissue International",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "92"
}
],
"keywords": [
"annual cumulative exposure",
"intermittent oral ibandronate",
"oral ibandronate",
"higher bone mineral density",
"new vertebral fractures",
"daily oral ibandronate",
"low bone turnover",
"postmenopausal osteoporotic women",
"months of treatment",
"bone mineral density",
"oral placebo",
"osteoporotic women",
"vertebral fractures",
"iliac biopsies",
"bone turnover",
"therapeutic doses",
"mineral density",
"ibandronate",
"placebo",
"analysis of covariance",
"cumulative exposure",
"total bone",
"PMOP women",
"months",
"regimens",
"women",
"bone tissue",
"bone",
"degree of mineralization",
"linear regression",
"levels",
"biopsy",
"patients",
"group",
"incidence",
"doses",
"treatment",
"total",
"tissue",
"y-intercept",
"exposure",
"unit level",
"fractures",
"regression",
"aim",
"changes",
"half",
"differences",
"study",
"DMB",
"effect",
"turnover",
"secondary mineralization",
"global level",
"degree",
"analysis",
"intercept",
"focal level",
"covariance",
"mineralization",
"distribution",
"density",
"properties",
"HV",
"micromechanical properties",
"BSU",
"microhardness"
],
"name": "Oral Ibandronate in Postmenopausal Osteoporotic Women Alters Micromechanical Properties Independently of Changes in Mineralization",
"pagination": "6-14",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1036510668"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00223-012-9658-6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"23090678"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00223-012-9658-6",
"https://app.dimensions.ai/details/publication/pub.1036510668"
],
"sdDataset": "articles",
"sdDatePublished": "2022-10-01T06:38",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_585.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00223-012-9658-6"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00223-012-9658-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00223-012-9658-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00223-012-9658-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00223-012-9658-6'
This table displays all metadata directly associated to this object as RDF triples.
248 TRIPLES
21 PREDICATES
115 URIs
101 LITERALS
24 BLANK NODES