Intrinsic Material Properties of Trabecular Bone by Nanoindentation Testing of Biopsies Taken from Healthy Women Before and After Menopause View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02-21

AUTHORS

Benjamin J. Polly, Philip A. Yuya, Mohammed P. Akhter, Robert R. Recker, Joseph A. Turner

ABSTRACT

Postmenopausal osteoporosis in women is characterized by an increase in bone fragility and risk of fracture. In addition to transmenopausal decline in three-dimensional trabecular bone architecture, changes in intrinsic material properties (local stiffness, damping, and hardness) may contribute to increased bone fragility. In this study, nanoindentation was used to quantify transmenopausal changes in the intrinsic properties of trabecular bone. Paired transilial biopsy specimens were used from a previously reported study in which bone biopsies were obtained from women prior to menopause (premenopausal, age 49.0 ± 1.9) and at 12 months past the last menstrual period (postmenopausal, age 54.6 ± 2.2). Elastic and viscoelastic material properties of the trabecular bone were measured using quasi-static and dynamic nanoindentation techniques, respectively. Paired Student’s t tests (n = 15) were performed to assess the significance of the measured intrinsic properties. Trabecular bone microarchitecture is compromised in postmenopausal women, and although this loss is associated with a trend toward reduction in some intrinsic properties (storage modulus), we found no statistically significant changes in bone intrinsic properties between healthy pre- and postmenopausal biopsies in the quasi-static results and frequency-averaged dynamic results. More... »

PAGES

286-293

References to SciGraph publications

  • 2010-08-22. Contribution of Mineral to Bone Structural Behavior and Tissue Mechanical Properties in CALCIFIED TISSUE INTERNATIONAL
  • 2009-09-12. Combination of Nanoindentation and Quantitative Backscattered Electron Imaging Revealed Altered Bone Material Properties Associated with Femoral Neck Fragility in CALCIFIED TISSUE INTERNATIONAL
  • 2005-08-09. Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation in OSTEOPOROSIS INTERNATIONAL
  • 2010-11-30. Methods for Assessing Bone Quality: A Review in CLINICAL ORTHOPAEDICS AND RELATED RESEARCH®
  • 2004-01. Nanoindentation of bone: Comparison of specimens tested in liquid and embedded in polymethylmethacrylate in JOURNAL OF MATERIALS RESEARCH
  • 2006-08-01. Hydration effects on the micro-mechanical properties of bone in JOURNAL OF MATERIALS RESEARCH
  • 2005-12-09. The role of collagen in bone strength in OSTEOPOROSIS INTERNATIONAL
  • 2010-03-02. Evaluating Anisotropic Properties in the Porcine Temporomandibular Joint Disc Using Nanoindentation in ANNALS OF BIOMEDICAL ENGINEERING
  • 1999-08. Effects of drying on the mechanical properties of bovine femur measured by nanoindentation in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • 1998-06. Musculoskeletal challenges of osteoporosis in AGING CLINICAL AND EXPERIMENTAL RESEARCH
  • 2006-08-01. Quasistatic and dynamic nanomechanical properties of cancellous bone tissue relate to collagen content and organization in JOURNAL OF MATERIALS RESEARCH
  • 1992-06. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments in JOURNAL OF MATERIALS RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00223-012-9575-8

    DOI

    http://dx.doi.org/10.1007/s00223-012-9575-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045357502

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22349078


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