A Preliminary Investigation into the Effects of X-Ray Radiation on Superficial Cranial Vascularization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-02-04

AUTHORS

Sophie Desmons, Michal Heger, Caroline Delfosse, Guillaume Falgayrac, Thierry Sarrazin, Claire Delattre, Sylvain Catros, Serge Mordon, Guillaume Penel

ABSTRACT

Radiation therapy (RT) is an established treatment modality for malignant neoplasms. RT induces tissue damage that may lead to osteoradionecrosis in more severe cases. Suitable animal models to study RT-induced changes in membranous craniofacial bone are currently not available. The aim of this study was therefore to quantify RT-induced changes in cranial microcirculation using a newly developed calvaria chamber model and to relate these changes to RT-induced histological damage. New Zealand white rabbits received a total radiation dose of 18.75 Gy through the calvaria chamber, and the number of vessels, the vessel length density (VLD), and angiogenic sprouting were quantified on a weekly basis during a 12-week period. At the end of 12 weeks, the RT-treated (n = 5) or control (n = 5) calvarias were biopsied for histopathological analysis. RT resulted in a steep reduction in the number of vessels and the VLD during the first 3 weeks, particularly in larger-diameter vessels, followed by a flat stabilization/remodeling phase in the subsequent 9 weeks that never restored to baseline values. Histomorphometric analysis revealed a high degree of osteocytic depletion, prominent hypocellularity in the lacunae and intraosseous vasculature, enlarged and nonconcentric Haversian systems, and a severely disorganized bone matrix in the RT-treated calvarias. Despite the prevalence of some angiogenic potential, the RT-induced effects in the early phase persisted in the intermediate to late phase, which may have contributed to the poor recovery of the RT-treated bone. More... »

PAGES

379-387

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00223-009-9217-y

DOI

http://dx.doi.org/10.1007/s00223-009-9217-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012188305

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19190840


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