Aspiration lesions of the amygdala disrupt the rhinal corticothalamic projection system in rhesus monkeys View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-02

AUTHORS

S. Goulet, F. Y. Doré, E. A. Murray

ABSTRACT

In macaque monkeys, aspiration but not excitotoxic lesions of the medial temporal lobe limbic structures, the amygdala and hippocampus, produce a severe impairment in visual recognition memory. Furthermore, certain ventromedial cortical regions, namely the rhinal (i.e., entorhinal and perirhinal) cortex, are now known to be critical for visual recognition memory. Because the route taken by temporal cortical efferent fibers, especially perirhinal efferents, passes nearby the amygdala, it is possible that inadvertent damage to these fibers is produced by the aspirative but not the excitotoxic process, thereby accounting at least in part for the different behavioral outcomes of the two types of lesion. To test this idea, we assessed the integrity of the rhinal corticothalamic projection system after aspiration lesions of the amygdala. Three rhesus monkeys with unilateral amygdala removals received bilaterally symmetrical injections of a retrograde fluorescent tracer into the medial portion of the mediodorsal nucleus of the thalamus. Retrogradely labeled cells were identified using conventional fluorescence microscopy techniques. In all three cases, the rhinal cortex of the intact hemispheres contained moderate numbers of retrogradely labeled cells. By contrast, the rhinal cortex of the amygdalectomized hemispheres consistently contained few retrogradely labeled cells, and a direct comparison of the two hemispheres showed this difference to be statistically significant. A similar asymmetric pattern was observed for area TE but not for the cortex lining the dorsal bank of the superior temporal sulcus, nor for the rostral cingulate motor area, which was examined as a control. The results indicate that aspiration lesions of the amygdala not only remove the cell bodies of the amygdala, as intended, but also inadvertently disrupt projection fibers arising from cells in the rhinal cortex and area TE that pass nearby or through the amygdala en route to the thalamus. Behavioral studies examining the effects of aspiration lesions of the amygdala in nonhuman primates need to take these findings into consideration. More... »

PAGES

131-140

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002210050326

DOI

http://dx.doi.org/10.1007/s002210050326

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038229419

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9535562


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amygdala", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inhalation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Limbic System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca mulatta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Suction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synaptic Transmission", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thalamus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Laval", 
          "id": "https://www.grid.ac/institutes/grid.23856.3a", 
          "name": [
            "Ecole de Psychologie, Universit\u00e9 Laval, Quebec, Qu\u00e9., Canada, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goulet", 
        "givenName": "S.", 
        "id": "sg:person.01065201010.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065201010.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Laval", 
          "id": "https://www.grid.ac/institutes/grid.23856.3a", 
          "name": [
            "Ecole de Psychologie, Universit\u00e9 Laval, Quebec, Qu\u00e9., Canada, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dor\u00e9", 
        "givenName": "F. Y.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Mental Health", 
          "id": "https://www.grid.ac/institutes/grid.416868.5", 
          "name": [
            "Laboratory of Neuropsychology, National Institute of Mental Health, Building 49, Room 1B80, 49 Convent Drive, Bethesda, MD 20892-4415, USA e-mail: eam@ln.nimh.nih.gov, Fax: +1-301-402-0046, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murray", 
        "givenName": "E. A.", 
        "id": "sg:person.013556240702.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013556240702.66"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998-02", 
    "datePublishedReg": "1998-02-01", 
    "description": "In macaque monkeys, aspiration but not excitotoxic lesions of the medial temporal lobe limbic structures, the amygdala and hippocampus, produce a severe impairment in visual recognition memory. Furthermore, certain ventromedial cortical regions, namely the rhinal (i.e., entorhinal and perirhinal) cortex, are now known to be critical for visual recognition memory. Because the route taken by temporal cortical efferent fibers, especially perirhinal efferents, passes nearby the amygdala, it is possible that inadvertent damage to these fibers is produced by the aspirative but not the excitotoxic process, thereby accounting at least in part for the different behavioral outcomes of the two types of lesion. To test this idea, we assessed the integrity of the rhinal corticothalamic projection system after aspiration lesions of the amygdala. Three rhesus monkeys with unilateral amygdala removals received bilaterally symmetrical injections of a retrograde fluorescent tracer into the medial portion of the mediodorsal nucleus of the thalamus. Retrogradely labeled cells were identified using conventional fluorescence microscopy techniques. In all three cases, the rhinal cortex of the intact hemispheres contained moderate numbers of retrogradely labeled cells. By contrast, the rhinal cortex of the amygdalectomized hemispheres consistently contained few retrogradely labeled cells, and a direct comparison of the two hemispheres showed this difference to be statistically significant. A similar asymmetric pattern was observed for area TE but not for the cortex lining the dorsal bank of the superior temporal sulcus, nor for the rostral cingulate motor area, which was examined as a control. The results indicate that aspiration lesions of the amygdala not only remove the cell bodies of the amygdala, as intended, but also inadvertently disrupt projection fibers arising from cells in the rhinal cortex and area TE that pass nearby or through the amygdala en route to the thalamus. Behavioral studies examining the effects of aspiration lesions of the amygdala in nonhuman primates need to take these findings into consideration.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s002210050326", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1005581", 
        "issn": [
          "0014-4819", 
          "1432-1106"
        ], 
        "name": "Experimental Brain Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "119"
      }
    ], 
    "name": "Aspiration lesions of the amygdala disrupt the rhinal corticothalamic projection system in rhesus monkeys", 
    "pagination": "131-140", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b61cdeb00bc7b4898b871a257bff76e65b6c9328bd63097b80f4839e9d37730b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9535562"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0043312"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002210050326"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038229419"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002210050326", 
      "https://app.dimensions.ai/details/publication/pub.1038229419"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs002210050326"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002210050326'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002210050326'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002210050326'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002210050326'


 

This table displays all metadata directly associated to this object as RDF triples.

129 TRIPLES      20 PREDICATES      40 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002210050326 schema:about N0cff91217a5440b1af21e13d49dc1fda
2 N146e98b9b7b643fb8b72530eeb7a83a2
3 N297cc030235d4e98bfc55addd1fcc448
4 N2aeeffdeed454efa9a447a287d36ed15
5 N680f93cddb164d6b9ba9ea4cc3cbdd27
6 N8eef83c5ea874a4cad2fdcca57f7746f
7 N9c50c2e8be30439f88c01c9ccf1c2a6f
8 Na9c8f9b3abbd4d4787b007aa70e62dec
9 Nb2a7681f72e4466bab883675974b8ba2
10 Nbad18637f6c34184a1f46959d22526e4
11 Ne771cf23b2704d5ea8d28f1975a88086
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author Neb619a901c8e4b329bc7bcba553c43ba
15 schema:datePublished 1998-02
16 schema:datePublishedReg 1998-02-01
17 schema:description In macaque monkeys, aspiration but not excitotoxic lesions of the medial temporal lobe limbic structures, the amygdala and hippocampus, produce a severe impairment in visual recognition memory. Furthermore, certain ventromedial cortical regions, namely the rhinal (i.e., entorhinal and perirhinal) cortex, are now known to be critical for visual recognition memory. Because the route taken by temporal cortical efferent fibers, especially perirhinal efferents, passes nearby the amygdala, it is possible that inadvertent damage to these fibers is produced by the aspirative but not the excitotoxic process, thereby accounting at least in part for the different behavioral outcomes of the two types of lesion. To test this idea, we assessed the integrity of the rhinal corticothalamic projection system after aspiration lesions of the amygdala. Three rhesus monkeys with unilateral amygdala removals received bilaterally symmetrical injections of a retrograde fluorescent tracer into the medial portion of the mediodorsal nucleus of the thalamus. Retrogradely labeled cells were identified using conventional fluorescence microscopy techniques. In all three cases, the rhinal cortex of the intact hemispheres contained moderate numbers of retrogradely labeled cells. By contrast, the rhinal cortex of the amygdalectomized hemispheres consistently contained few retrogradely labeled cells, and a direct comparison of the two hemispheres showed this difference to be statistically significant. A similar asymmetric pattern was observed for area TE but not for the cortex lining the dorsal bank of the superior temporal sulcus, nor for the rostral cingulate motor area, which was examined as a control. The results indicate that aspiration lesions of the amygdala not only remove the cell bodies of the amygdala, as intended, but also inadvertently disrupt projection fibers arising from cells in the rhinal cortex and area TE that pass nearby or through the amygdala en route to the thalamus. Behavioral studies examining the effects of aspiration lesions of the amygdala in nonhuman primates need to take these findings into consideration.
18 schema:genre research_article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N437e5f5fdb4b4e828e3f36d0b9e85563
22 Nda312524956c4da18d497a97c8bfa544
23 sg:journal.1005581
24 schema:name Aspiration lesions of the amygdala disrupt the rhinal corticothalamic projection system in rhesus monkeys
25 schema:pagination 131-140
26 schema:productId N0ea821dd4cae4a2fa946db50f38a0eef
27 N4a7e3621030741448d955eb680205b79
28 N5ad4983dea7046e2b57feafbf3cdae29
29 Nbf9bbb32a45a49268edacd60355457d7
30 Nd2d6caef149643cb921fe5fa7ed3c253
31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038229419
32 https://doi.org/10.1007/s002210050326
33 schema:sdDatePublished 2019-04-10T15:05
34 schema:sdLicense https://scigraph.springernature.com/explorer/license/
35 schema:sdPublisher N6570cd075bcd4cf7a1b3f177e287a69d
36 schema:url http://link.springer.com/10.1007%2Fs002210050326
37 sgo:license sg:explorer/license/
38 sgo:sdDataset articles
39 rdf:type schema:ScholarlyArticle
40 N0cff91217a5440b1af21e13d49dc1fda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
41 schema:name Brain Mapping
42 rdf:type schema:DefinedTerm
43 N0ea821dd4cae4a2fa946db50f38a0eef schema:name nlm_unique_id
44 schema:value 0043312
45 rdf:type schema:PropertyValue
46 N146e98b9b7b643fb8b72530eeb7a83a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
47 schema:name Cerebral Cortex
48 rdf:type schema:DefinedTerm
49 N297cc030235d4e98bfc55addd1fcc448 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
50 schema:name Limbic System
51 rdf:type schema:DefinedTerm
52 N2aeeffdeed454efa9a447a287d36ed15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
53 schema:name Thalamus
54 rdf:type schema:DefinedTerm
55 N2f73977335b14a888a34bb7d3da08d3b rdf:first N8ca277a707544e54b051b8f7eb7c30b3
56 rdf:rest N91b2da6ac76345e2846eef0776392953
57 N437e5f5fdb4b4e828e3f36d0b9e85563 schema:issueNumber 2
58 rdf:type schema:PublicationIssue
59 N4a7e3621030741448d955eb680205b79 schema:name doi
60 schema:value 10.1007/s002210050326
61 rdf:type schema:PropertyValue
62 N5ad4983dea7046e2b57feafbf3cdae29 schema:name dimensions_id
63 schema:value pub.1038229419
64 rdf:type schema:PropertyValue
65 N6570cd075bcd4cf7a1b3f177e287a69d schema:name Springer Nature - SN SciGraph project
66 rdf:type schema:Organization
67 N680f93cddb164d6b9ba9ea4cc3cbdd27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Amygdala
69 rdf:type schema:DefinedTerm
70 N8ca277a707544e54b051b8f7eb7c30b3 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
71 schema:familyName Doré
72 schema:givenName F. Y.
73 rdf:type schema:Person
74 N8eef83c5ea874a4cad2fdcca57f7746f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Animals
76 rdf:type schema:DefinedTerm
77 N91b2da6ac76345e2846eef0776392953 rdf:first sg:person.013556240702.66
78 rdf:rest rdf:nil
79 N9c50c2e8be30439f88c01c9ccf1c2a6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Inhalation
81 rdf:type schema:DefinedTerm
82 Na9c8f9b3abbd4d4787b007aa70e62dec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Suction
84 rdf:type schema:DefinedTerm
85 Nb2a7681f72e4466bab883675974b8ba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Brain Diseases
87 rdf:type schema:DefinedTerm
88 Nbad18637f6c34184a1f46959d22526e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Macaca mulatta
90 rdf:type schema:DefinedTerm
91 Nbf9bbb32a45a49268edacd60355457d7 schema:name pubmed_id
92 schema:value 9535562
93 rdf:type schema:PropertyValue
94 Nd2d6caef149643cb921fe5fa7ed3c253 schema:name readcube_id
95 schema:value b61cdeb00bc7b4898b871a257bff76e65b6c9328bd63097b80f4839e9d37730b
96 rdf:type schema:PropertyValue
97 Nda312524956c4da18d497a97c8bfa544 schema:volumeNumber 119
98 rdf:type schema:PublicationVolume
99 Ne771cf23b2704d5ea8d28f1975a88086 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Synaptic Transmission
101 rdf:type schema:DefinedTerm
102 Neb619a901c8e4b329bc7bcba553c43ba rdf:first sg:person.01065201010.02
103 rdf:rest N2f73977335b14a888a34bb7d3da08d3b
104 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
105 schema:name Medical and Health Sciences
106 rdf:type schema:DefinedTerm
107 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
108 schema:name Neurosciences
109 rdf:type schema:DefinedTerm
110 sg:journal.1005581 schema:issn 0014-4819
111 1432-1106
112 schema:name Experimental Brain Research
113 rdf:type schema:Periodical
114 sg:person.01065201010.02 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
115 schema:familyName Goulet
116 schema:givenName S.
117 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065201010.02
118 rdf:type schema:Person
119 sg:person.013556240702.66 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
120 schema:familyName Murray
121 schema:givenName E. A.
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013556240702.66
123 rdf:type schema:Person
124 https://www.grid.ac/institutes/grid.23856.3a schema:alternateName Université Laval
125 schema:name Ecole de Psychologie, Université Laval, Quebec, Qué., Canada, CA
126 rdf:type schema:Organization
127 https://www.grid.ac/institutes/grid.416868.5 schema:alternateName National Institute of Mental Health
128 schema:name Laboratory of Neuropsychology, National Institute of Mental Health, Building 49, Room 1B80, 49 Convent Drive, Bethesda, MD 20892-4415, USA e-mail: eam@ln.nimh.nih.gov, Fax: +1-301-402-0046, US
129 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...