Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11-16

AUTHORS

Donat Kögel, Thomas Deller, Christian Behl

ABSTRACT

The roles of amyloid precursor protein (APP) family members in normal brain function are poorly understood. Under physiological conditions the majority of APP appears to be processed along the non-amyloidogenic pathway leading to the formation of the secreted N-terminal APP fragment sAPPα. This cleavage product of APP has been implicated in several physiological processes such as neuroprotection, synaptic plasticity, neurite outgrowth and synaptogenesis. In this review we focus on the role of APP family members in neuroprotection and summarize the cellular and molecular mechanisms which are believed to mediate this effect. We propose that a reduction of APP processing along the non-amyloidogenic pathway during brain aging could result in an enhanced susceptibility of neurons to cellular stress and could contribute to neurodegeneration in Alzheimer’s disease. More... »

PAGES

471-479

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00221-011-2932-4

DOI

http://dx.doi.org/10.1007/s00221-011-2932-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053429131

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22086493


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202 schema:name Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
203 rdf:type schema:Organization
 




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