Designation of fingerprint glycopeptides for targeted glycoproteomic analysis of serum haptoglobin: insights into gastric cancer biomarker discovery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-02

AUTHORS

Jua Lee, Serenus Hua, Sung Hyeon Lee, Myung Jin Oh, Jaekyung Yun, Jin Young Kim, Jae-Han Kim, Jung Hoe Kim, Hyun Joo An

ABSTRACT

Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide, largely because of difficulties in early diagnosis. Despite accumulating evidence indicating that aberrant glycosylation is associated with GC, site-specific localization of the glycosylation to increase specificity and sensitivity for clinical use is still an analytical challenge. Here, we created an analytical platform with a targeted glycoproteomic approach for GC biomarker discovery. Unlike the conventional glycomic approach with untargeted mass spectrometric profiling of released glycan, our platform is characterized by three key features: it is a target-protein-specific, glycosylation-site-specific, and structure-specific platform with a one-shot enzyme reaction. Serum haptoglobin enriched by immunoaffinity chromatography was subjected to multispecific proteolysis to generate site-specific glycopeptides and to investigate the macroheterogeneity and microheterogeneity. Glycopeptides were identified and quantified by nano liquid chromatography-mass spectrometry and nano liquid chromatography-tandem mass spectrometry. Ninety-six glycopeptides, each corresponding to a unique glycan/glycosite pairing, were tracked across all cancer and control samples. Differences in abundance between the two groups were marked by particularly high magnitudes. Three glycopeptides exhibited exceptionally high control-to-cancer fold changes along with receiver operating characteristic curve areas of 1.0, indicating perfect discrimination between the two groups. From the results taken together, our platform, which provides biological information as well as high sensitivity and reproducibility, may be useful for GC biomarker discovery. Graphical abstract ᅟ. More... »

PAGES

1617-1629

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00216-017-0811-y

DOI

http://dx.doi.org/10.1007/s00216-017-0811-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100111626

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29285644


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycosylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haptoglobins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tandem Mass Spectrometry", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chungnam National University", 
          "id": "https://www.grid.ac/institutes/grid.254230.2", 
          "name": [
            "Asia Glycomics Reference Site, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea", 
            "Graduate School of Analytical Science and Technology, #455 College of Engineering II, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jua", 
        "id": "sg:person.0736571173.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736571173.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungnam National University", 
          "id": "https://www.grid.ac/institutes/grid.254230.2", 
          "name": [
            "Asia Glycomics Reference Site, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea", 
            "Graduate School of Analytical Science and Technology, #455 College of Engineering II, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hua", 
        "givenName": "Serenus", 
        "id": "sg:person.01172514622.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172514622.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "GLYCAN Co. Ltd., Healthcare Innovation Park, 172 Dolma-ro, Bundang-gu, 13605, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sung Hyeon", 
        "id": "sg:person.01277065707.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277065707.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungnam National University", 
          "id": "https://www.grid.ac/institutes/grid.254230.2", 
          "name": [
            "Asia Glycomics Reference Site, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea", 
            "Graduate School of Analytical Science and Technology, #455 College of Engineering II, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Myung Jin", 
        "id": "sg:person.01261250172.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261250172.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungnam National University", 
          "id": "https://www.grid.ac/institutes/grid.254230.2", 
          "name": [
            "Asia Glycomics Reference Site, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea", 
            "Graduate School of Analytical Science and Technology, #455 College of Engineering II, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yun", 
        "givenName": "Jaekyung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Basic Science Institute", 
          "id": "https://www.grid.ac/institutes/grid.410885.0", 
          "name": [
            "Department of Mass Spectrometry, Korea Basic Science Institute, 863-883, Ochang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jin Young", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungnam National University", 
          "id": "https://www.grid.ac/institutes/grid.254230.2", 
          "name": [
            "Department of Food and Nutrition, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jae-Han", 
        "id": "sg:person.0773015276.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773015276.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Advanced Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.37172.30", 
          "name": [
            "Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, 34141, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jung Hoe", 
        "id": "sg:person.01300137557.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300137557.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungnam National University", 
          "id": "https://www.grid.ac/institutes/grid.254230.2", 
          "name": [
            "Asia Glycomics Reference Site, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea", 
            "Graduate School of Analytical Science and Technology, #455 College of Engineering II, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "An", 
        "givenName": "Hyun Joo", 
        "id": "sg:person.01002675157.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002675157.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1940-6207.capr-13-0235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001709679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c6mb00559d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004092158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jms.3210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005026695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0068863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006128855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200800760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007143671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200800760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007143671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2004.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011317328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-1176(97)00219-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012687313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.12.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014169090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0026560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016759945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10337-014-2813-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019339575", 
          "https://doi.org/10.1007/s10337-014-2813-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10337-014-2813-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019339575", 
          "https://doi.org/10.1007/s10337-014-2813-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10337-014-2813-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019339575", 
          "https://doi.org/10.1007/s10337-014-2813-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trac.2015.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020845835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr400589m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022910462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbapap.2014.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023259698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m114.046862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023604905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/clinchem.2003.028001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025653620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2012.12.079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026429087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2012.12.079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026429087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2003.07410.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026663913", 
          "https://doi.org/10.1111/j.1572-0241.2003.07410.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m115.047928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028227215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0015-0282(02)03317-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030320813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jprot.2013.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030742680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0022844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031307458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-012-0141-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031759191", 
          "https://doi.org/10.1007/s10120-012-0141-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c1an15093f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033025530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.14362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036462207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036508003", 
          "https://doi.org/10.1038/nrc3982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bib/bbs045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038576553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.27501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047155143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.26288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049653223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051425468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051894484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5483/bmbrep.2012.45.6.132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052253038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac034414x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054995098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac034414x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054995098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac4006556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055004210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac9813484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055075856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac9813484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055075856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr0602949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056291160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr1009959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056292384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr301217b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056293343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr400442y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056293509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr400987f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056293694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/glycob/cww016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059639082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.172.3979.169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062502603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-15-0578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063224193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v19.i5.736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071370187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082977859", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/jca.17747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084480910"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-02", 
    "datePublishedReg": "2018-02-01", 
    "description": "Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide, largely because of difficulties in early diagnosis. Despite accumulating evidence indicating that aberrant glycosylation is associated with GC, site-specific localization of the glycosylation to increase specificity and sensitivity for clinical use is still an analytical challenge. Here, we created an analytical platform with a targeted glycoproteomic approach for GC biomarker discovery. Unlike the conventional glycomic approach with untargeted mass spectrometric profiling of released glycan, our platform is characterized by three key features: it is a target-protein-specific, glycosylation-site-specific, and structure-specific platform with a one-shot enzyme reaction. Serum haptoglobin enriched by immunoaffinity chromatography was subjected to multispecific proteolysis to generate site-specific glycopeptides and to investigate the macroheterogeneity and microheterogeneity. Glycopeptides were identified and quantified by nano liquid chromatography-mass spectrometry and nano liquid chromatography-tandem mass spectrometry. Ninety-six glycopeptides, each corresponding to a unique glycan/glycosite pairing, were tracked across all cancer and control samples. Differences in abundance between the two groups were marked by particularly high magnitudes. Three glycopeptides exhibited exceptionally high control-to-cancer fold changes along with receiver operating characteristic curve areas of 1.0, indicating perfect discrimination between the two groups. From the results taken together, our platform, which provides biological information as well as high sensitivity and reproducibility, may be useful for GC biomarker discovery. Graphical abstract \u115f.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00216-017-0811-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1357342", 
        "issn": [
          "1618-2642", 
          "1618-2650"
        ], 
        "name": "Analytical and Bioanalytical Chemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "410"
      }
    ], 
    "name": "Designation of fingerprint glycopeptides for targeted glycoproteomic analysis of serum haptoglobin: insights into gastric cancer biomarker discovery", 
    "pagination": "1617-1629", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b05e8511226fa78fa5f309cb496513632bb4ef5a45bf18d98c160ea3693ed348"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29285644"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101134327"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00216-017-0811-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100111626"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00216-017-0811-y", 
      "https://app.dimensions.ai/details/publication/pub.1100111626"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000603.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00216-017-0811-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00216-017-0811-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00216-017-0811-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00216-017-0811-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00216-017-0811-y'


 

This table displays all metadata directly associated to this object as RDF triples.

311 TRIPLES      21 PREDICATES      84 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00216-017-0811-y schema:about N2e532f878dc848a1a984f839c3ee2b6f
2 N4b2983b18972485bba65f5af59e34807
3 N6c4e7ee416dc49babd512961cda50823
4 N88687b030b6c4c0fbc59e2204a1d3ce8
5 N9680f2c53e2442b2a5c3697741978f25
6 N9e0b626e756d4514bee6c938cb499209
7 Nb068129835d74af09475e6450ac138ef
8 Nc3589b33fa8c449c972f60f5cc462e96
9 Nf172bcbbc7ae4969b4fe8ad9de7c72aa
10 Nf8716642ad1e4321bba50df9e814dc2a
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N228ea7bed8ed4fd08afe36ab1d1fbbb5
14 schema:citation sg:pub.10.1007/s10120-012-0141-x
15 sg:pub.10.1007/s10337-014-2813-7
16 sg:pub.10.1038/nrc3982
17 sg:pub.10.1111/j.1572-0241.2003.07410.x
18 https://app.dimensions.ai/details/publication/pub.1082977859
19 https://doi.org/10.1002/ijc.24685
20 https://doi.org/10.1002/ijc.26288
21 https://doi.org/10.1002/ijc.27501
22 https://doi.org/10.1002/jms.3210
23 https://doi.org/10.1002/pmic.200800760
24 https://doi.org/10.1016/j.bbapap.2014.05.002
25 https://doi.org/10.1016/j.bbrc.2008.12.139
26 https://doi.org/10.1016/j.cell.2010.11.008
27 https://doi.org/10.1016/j.chroma.2012.12.079
28 https://doi.org/10.1016/j.jprot.2013.04.017
29 https://doi.org/10.1016/j.trac.2015.02.004
30 https://doi.org/10.1016/s0015-0282(02)03317-4
31 https://doi.org/10.1016/s0168-1176(97)00219-x
32 https://doi.org/10.1021/ac034414x
33 https://doi.org/10.1021/ac4006556
34 https://doi.org/10.1021/ac9813484
35 https://doi.org/10.1021/pr0602949
36 https://doi.org/10.1021/pr1009959
37 https://doi.org/10.1021/pr301217b
38 https://doi.org/10.1021/pr400442y
39 https://doi.org/10.1021/pr400589m
40 https://doi.org/10.1021/pr400987f
41 https://doi.org/10.1039/c1an15093f
42 https://doi.org/10.1039/c6mb00559d
43 https://doi.org/10.1053/j.gastro.2004.06.016
44 https://doi.org/10.1074/mcp.m114.046862
45 https://doi.org/10.1074/mcp.m115.047928
46 https://doi.org/10.1093/bib/bbs045
47 https://doi.org/10.1093/glycob/cww016
48 https://doi.org/10.1126/science.172.3979.169
49 https://doi.org/10.1158/1055-9965.epi-15-0578
50 https://doi.org/10.1158/1940-6207.capr-13-0235
51 https://doi.org/10.1371/journal.pone.0022844
52 https://doi.org/10.1371/journal.pone.0026560
53 https://doi.org/10.1371/journal.pone.0068863
54 https://doi.org/10.1373/clinchem.2003.028001
55 https://doi.org/10.18632/oncotarget.14362
56 https://doi.org/10.3748/wjg.v19.i5.736
57 https://doi.org/10.5483/bmbrep.2012.45.6.132
58 https://doi.org/10.7150/jca.17747
59 schema:datePublished 2018-02
60 schema:datePublishedReg 2018-02-01
61 schema:description Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide, largely because of difficulties in early diagnosis. Despite accumulating evidence indicating that aberrant glycosylation is associated with GC, site-specific localization of the glycosylation to increase specificity and sensitivity for clinical use is still an analytical challenge. Here, we created an analytical platform with a targeted glycoproteomic approach for GC biomarker discovery. Unlike the conventional glycomic approach with untargeted mass spectrometric profiling of released glycan, our platform is characterized by three key features: it is a target-protein-specific, glycosylation-site-specific, and structure-specific platform with a one-shot enzyme reaction. Serum haptoglobin enriched by immunoaffinity chromatography was subjected to multispecific proteolysis to generate site-specific glycopeptides and to investigate the macroheterogeneity and microheterogeneity. Glycopeptides were identified and quantified by nano liquid chromatography-mass spectrometry and nano liquid chromatography-tandem mass spectrometry. Ninety-six glycopeptides, each corresponding to a unique glycan/glycosite pairing, were tracked across all cancer and control samples. Differences in abundance between the two groups were marked by particularly high magnitudes. Three glycopeptides exhibited exceptionally high control-to-cancer fold changes along with receiver operating characteristic curve areas of 1.0, indicating perfect discrimination between the two groups. From the results taken together, our platform, which provides biological information as well as high sensitivity and reproducibility, may be useful for GC biomarker discovery. Graphical abstract ᅟ.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N269733df62514bea94f545c3c6a76034
66 Na71631258dd5450f9ef37d6b12ab52c1
67 sg:journal.1357342
68 schema:name Designation of fingerprint glycopeptides for targeted glycoproteomic analysis of serum haptoglobin: insights into gastric cancer biomarker discovery
69 schema:pagination 1617-1629
70 schema:productId N0f1bfad807ae4ccfba059db0ad24bdff
71 N7730aae5685f404f8464fd99a232dad1
72 N8270fdb111ae48d3aaf6da0731fa844b
73 Nc769ddd763984a5f95f90cafa4083164
74 Nca1961ac45c6452b8b2612decd02b584
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100111626
76 https://doi.org/10.1007/s00216-017-0811-y
77 schema:sdDatePublished 2019-04-10T16:05
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N87e24cb8b1bb4df4a307c53111b50821
80 schema:url http://link.springer.com/10.1007/s00216-017-0811-y
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N05437189aa6b4ba886c034a810febaaf schema:name GLYCAN Co. Ltd., Healthcare Innovation Park, 172 Dolma-ro, Bundang-gu, 13605, Seongnam, Republic of Korea
85 rdf:type schema:Organization
86 N0f1bfad807ae4ccfba059db0ad24bdff schema:name dimensions_id
87 schema:value pub.1100111626
88 rdf:type schema:PropertyValue
89 N20328732aeab4ad0b776420092b14e73 rdf:first sg:person.01277065707.19
90 rdf:rest N5f36b4505e9c4636a2760ec4a65071d8
91 N228ea7bed8ed4fd08afe36ab1d1fbbb5 rdf:first sg:person.0736571173.29
92 rdf:rest N902b6e84e83c4aa3a4f7e97d4b49b652
93 N269733df62514bea94f545c3c6a76034 schema:volumeNumber 410
94 rdf:type schema:PublicationVolume
95 N2e532f878dc848a1a984f839c3ee2b6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Proteolysis
97 rdf:type schema:DefinedTerm
98 N4b2983b18972485bba65f5af59e34807 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Models, Molecular
100 rdf:type schema:DefinedTerm
101 N5f36b4505e9c4636a2760ec4a65071d8 rdf:first sg:person.01261250172.89
102 rdf:rest Na4c6c7f92fba4c80a4e12d26246e11a7
103 N6c4e7ee416dc49babd512961cda50823 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Glycopeptides
105 rdf:type schema:DefinedTerm
106 N7730aae5685f404f8464fd99a232dad1 schema:name pubmed_id
107 schema:value 29285644
108 rdf:type schema:PropertyValue
109 N8270fdb111ae48d3aaf6da0731fa844b schema:name nlm_unique_id
110 schema:value 101134327
111 rdf:type schema:PropertyValue
112 N87e24cb8b1bb4df4a307c53111b50821 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N88687b030b6c4c0fbc59e2204a1d3ce8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Stomach Neoplasms
116 rdf:type schema:DefinedTerm
117 N899c6fca119945f28fdd026305e6f924 schema:affiliation https://www.grid.ac/institutes/grid.254230.2
118 schema:familyName Yun
119 schema:givenName Jaekyung
120 rdf:type schema:Person
121 N8c643cd6238d4dc6ae3e8b4bff8a34ec rdf:first N9182d0307a924072b2a292cc97f741eb
122 rdf:rest Na8a7b08abf294ad5b4fe880aed428e93
123 N902b6e84e83c4aa3a4f7e97d4b49b652 rdf:first sg:person.01172514622.26
124 rdf:rest N20328732aeab4ad0b776420092b14e73
125 N9182d0307a924072b2a292cc97f741eb schema:affiliation https://www.grid.ac/institutes/grid.410885.0
126 schema:familyName Kim
127 schema:givenName Jin Young
128 rdf:type schema:Person
129 N9680f2c53e2442b2a5c3697741978f25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Haptoglobins
131 rdf:type schema:DefinedTerm
132 N9e0b626e756d4514bee6c938cb499209 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 Na4c6c7f92fba4c80a4e12d26246e11a7 rdf:first N899c6fca119945f28fdd026305e6f924
136 rdf:rest N8c643cd6238d4dc6ae3e8b4bff8a34ec
137 Na71631258dd5450f9ef37d6b12ab52c1 schema:issueNumber 6
138 rdf:type schema:PublicationIssue
139 Na8a7b08abf294ad5b4fe880aed428e93 rdf:first sg:person.0773015276.43
140 rdf:rest Nd903c68587e24f5190365d1837dc60e8
141 Nb068129835d74af09475e6450ac138ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Biomarkers, Tumor
143 rdf:type schema:DefinedTerm
144 Nc3589b33fa8c449c972f60f5cc462e96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Tandem Mass Spectrometry
146 rdf:type schema:DefinedTerm
147 Nc769ddd763984a5f95f90cafa4083164 schema:name readcube_id
148 schema:value b05e8511226fa78fa5f309cb496513632bb4ef5a45bf18d98c160ea3693ed348
149 rdf:type schema:PropertyValue
150 Nca1961ac45c6452b8b2612decd02b584 schema:name doi
151 schema:value 10.1007/s00216-017-0811-y
152 rdf:type schema:PropertyValue
153 Nd903c68587e24f5190365d1837dc60e8 rdf:first sg:person.01300137557.41
154 rdf:rest Nef4cead77de44ca48808cbf219b5a3ec
155 Nef4cead77de44ca48808cbf219b5a3ec rdf:first sg:person.01002675157.10
156 rdf:rest rdf:nil
157 Nf172bcbbc7ae4969b4fe8ad9de7c72aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Glycosylation
159 rdf:type schema:DefinedTerm
160 Nf8716642ad1e4321bba50df9e814dc2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Proteomics
162 rdf:type schema:DefinedTerm
163 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biological Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
167 schema:name Biochemistry and Cell Biology
168 rdf:type schema:DefinedTerm
169 sg:journal.1357342 schema:issn 1618-2642
170 1618-2650
171 schema:name Analytical and Bioanalytical Chemistry
172 rdf:type schema:Periodical
173 sg:person.01002675157.10 schema:affiliation https://www.grid.ac/institutes/grid.254230.2
174 schema:familyName An
175 schema:givenName Hyun Joo
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002675157.10
177 rdf:type schema:Person
178 sg:person.01172514622.26 schema:affiliation https://www.grid.ac/institutes/grid.254230.2
179 schema:familyName Hua
180 schema:givenName Serenus
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172514622.26
182 rdf:type schema:Person
183 sg:person.01261250172.89 schema:affiliation https://www.grid.ac/institutes/grid.254230.2
184 schema:familyName Oh
185 schema:givenName Myung Jin
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261250172.89
187 rdf:type schema:Person
188 sg:person.01277065707.19 schema:affiliation N05437189aa6b4ba886c034a810febaaf
189 schema:familyName Lee
190 schema:givenName Sung Hyeon
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277065707.19
192 rdf:type schema:Person
193 sg:person.01300137557.41 schema:affiliation https://www.grid.ac/institutes/grid.37172.30
194 schema:familyName Kim
195 schema:givenName Jung Hoe
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300137557.41
197 rdf:type schema:Person
198 sg:person.0736571173.29 schema:affiliation https://www.grid.ac/institutes/grid.254230.2
199 schema:familyName Lee
200 schema:givenName Jua
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736571173.29
202 rdf:type schema:Person
203 sg:person.0773015276.43 schema:affiliation https://www.grid.ac/institutes/grid.254230.2
204 schema:familyName Kim
205 schema:givenName Jae-Han
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773015276.43
207 rdf:type schema:Person
208 sg:pub.10.1007/s10120-012-0141-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031759191
209 https://doi.org/10.1007/s10120-012-0141-x
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s10337-014-2813-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019339575
212 https://doi.org/10.1007/s10337-014-2813-7
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/nrc3982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508003
215 https://doi.org/10.1038/nrc3982
216 rdf:type schema:CreativeWork
217 sg:pub.10.1111/j.1572-0241.2003.07410.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026663913
218 https://doi.org/10.1111/j.1572-0241.2003.07410.x
219 rdf:type schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1082977859 schema:CreativeWork
221 https://doi.org/10.1002/ijc.24685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051894484
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/ijc.26288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049653223
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1002/ijc.27501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047155143
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/jms.3210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005026695
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1002/pmic.200800760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007143671
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.bbapap.2014.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023259698
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.bbrc.2008.12.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014169090
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.cell.2010.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051425468
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.chroma.2012.12.079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026429087
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.jprot.2013.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030742680
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.trac.2015.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020845835
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0015-0282(02)03317-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030320813
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0168-1176(97)00219-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012687313
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1021/ac034414x schema:sameAs https://app.dimensions.ai/details/publication/pub.1054995098
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1021/ac4006556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055004210
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1021/ac9813484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055075856
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1021/pr0602949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056291160
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1021/pr1009959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056292384
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1021/pr301217b schema:sameAs https://app.dimensions.ai/details/publication/pub.1056293343
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1021/pr400442y schema:sameAs https://app.dimensions.ai/details/publication/pub.1056293509
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1021/pr400589m schema:sameAs https://app.dimensions.ai/details/publication/pub.1022910462
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1021/pr400987f schema:sameAs https://app.dimensions.ai/details/publication/pub.1056293694
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1039/c1an15093f schema:sameAs https://app.dimensions.ai/details/publication/pub.1033025530
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1039/c6mb00559d schema:sameAs https://app.dimensions.ai/details/publication/pub.1004092158
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1053/j.gastro.2004.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011317328
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1074/mcp.m114.046862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023604905
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1074/mcp.m115.047928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028227215
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1093/bib/bbs045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038576553
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1093/glycob/cww016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059639082
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1126/science.172.3979.169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062502603
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1158/1055-9965.epi-15-0578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063224193
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1158/1940-6207.capr-13-0235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001709679
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1371/journal.pone.0022844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031307458
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1371/journal.pone.0026560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016759945
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1371/journal.pone.0068863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006128855
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1373/clinchem.2003.028001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025653620
292 rdf:type schema:CreativeWork
293 https://doi.org/10.18632/oncotarget.14362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036462207
294 rdf:type schema:CreativeWork
295 https://doi.org/10.3748/wjg.v19.i5.736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071370187
296 rdf:type schema:CreativeWork
297 https://doi.org/10.5483/bmbrep.2012.45.6.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052253038
298 rdf:type schema:CreativeWork
299 https://doi.org/10.7150/jca.17747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084480910
300 rdf:type schema:CreativeWork
301 https://www.grid.ac/institutes/grid.254230.2 schema:alternateName Chungnam National University
302 schema:name Asia Glycomics Reference Site, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea
303 Department of Food and Nutrition, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea
304 Graduate School of Analytical Science and Technology, #455 College of Engineering II, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.37172.30 schema:alternateName Korea Advanced Institute of Science and Technology
307 schema:name Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, 34141, Daejeon, Republic of Korea
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.410885.0 schema:alternateName Korea Basic Science Institute
310 schema:name Department of Mass Spectrometry, Korea Basic Science Institute, 863-883, Ochang, Republic of Korea
311 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...