An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08-25

AUTHORS

Yildiz Uludag, Fehmi Narter, Erkin Sağlam, Güzin Köktürk, M. Yağmur Gök, Mete Akgün, Serkan Barut, Sinan Budak

ABSTRACT

Recent advances in the area of biosensor technology and microfluidic applications have enabled the miniaturisation of the sensing platforms. Here we describe a new integrated and fully automated lab-on-a-chip-based biosensor device prototype (MiSens) that has potential to be used for point-of-care cancer biomarker testing. The key features of the device include a new biochip, a device integrated microfluidic system and real-time amperometric measurements during the flow of enzyme substrate. For ease of use, a new plug and play type sensor chip docking station has been designed. This system allows the formation of an ∼7 μL capacity flow cell on the electrode array with the necessary microfluidic and electronic connections with one move of a handle. As a case study, the developed prototype has been utilised for the detection of prostate-specific antigen (PSA) level in serum that is routinely used as a biomarker for the diagnosis of prostate cancer. The patient samples from a nearby hospital have been collected and tested using the MiSens device, and the results have been compared to the hospital results. The obtained results indicate the potential of the MiSens device as a useful tool for point-of-care testing.Graphical abstractMicrofluidics integrated and automated electrochemical biosensor device “MiSens” has been designed and fabricated by a multidisciplinary team and utilised to detect PSA from clinical samples. More... »

PAGES

7775-7783

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00216-016-9879-z

DOI

http://dx.doi.org/10.1007/s00216-016-9879-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014453264

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27562751


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