Size and shape characterization of hydrated and desiccated exosomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05

AUTHORS

Vasiliy S. Chernyshev, Rakesh Rachamadugu, Yen Hsun Tseng, David M. Belnap, Yunlu Jia, Kyle J. Branch, Anthony E. Butterfield, Leonard F. Pease, Philip S. Bernard, Mikhail Skliar

ABSTRACT

Exosomes are stable nanovesicles secreted by cells into the circulation. Their reported sizes differ substantially, which likely reflects the difference in the isolation techniques used, the cells that secreted them, and the methods used in their characterization. We analyzed the influence of the last factor on the measured sizes and shapes of hydrated and desiccated exosomes isolated from the serum of a pancreatic cancer patient and a healthy control. We found that hydrated exosomes are close-to-spherical nanoparticles with a hydrodynamic radius that is substantially larger than the geometric size. For desiccated exosomes, we found that the desiccated shape and sizing are influenced by the manner in which drying occurred. Isotropic desiccation in aerosol preserves the near-spherical shape of the exosomes, whereas drying on a surface likely distorts their shapes and influences the sizing results obtained by techniques that require surface fixation prior to analysis. More... »

PAGES

3285-3301

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00216-015-8535-3

    DOI

    http://dx.doi.org/10.1007/s00216-015-8535-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002375412

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25821114


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