Mass-spectrometry-based microbial metabolomics: recent developments and applications View Full Text


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Article Info

DATE

2015-01

AUTHORS

Peng Gao, Guowang Xu

ABSTRACT

Metabolomics is an omics technique aiming at qualitatively and quantitatively describing a metabolome by various analytical platforms. It is an indispensable component of modern systems biology. Microbial metabolomics can be roughly classified as metabolic footprint analysis and metabolic fingerprint analysis depending on the analyte origins. Both of them have been beneficial to microbiological research for different reasons. Mass spectrometry and nuclear magnetic resonance spectroscopy techniques are popular analytical strategies prevailing in the metabolomics field. In this review, chromatography-mass-spectrometry-based microbial metabolomic analysis steps are summarized, including sample collection, metabolite extraction, instrument analysis, and data analysis. Moreover, their applications in some representative fields are discussed as examples. The aim of this review is to present briefly recent technical advances in mass-spectrometry-based analysis, and to highlight the value of modern applications of microbial metabolomics. More... »

PAGES

669-680

References to SciGraph publications

  • 2007-10. Comparison of quenching and extraction methodologies for metabolome analysis of Lactobacillus plantarum in MICROBIAL CELL FACTORIES
  • 2007-08. Fast sampling and quenching procedures for microbial metabolic profiling in BIOTECHNOLOGY LETTERS
  • 2001-01. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations in NATURE BIOTECHNOLOGY
  • 2004-01. The challenge of multidrug resistance: actual strategies in the development of novel antibacterials in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2011-04. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease in NATURE
  • 2005-06. Microbial metabolomics: replacing trial-and-error by the unbiased selection and ranking of targets in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2007. A Gentle Guide to the Analysis of Metabolomic Data in METABOLOMICS
  • 2014-12. Identifying inhibitory compounds in lignocellulosic biomass hydrolysates using an exometabolomics approach in BMC BIOTECHNOLOGY
  • 2013-12. Integrated OMICS guided engineering of biofuel butanol-tolerance in photosynthetic Synechocystissp. PCC 6803 in BIOTECHNOLOGY FOR BIOFUELS
  • 2014-06. Comprehensive and simultaneous coverage of lipid and polar metabolites for endogenous cellular metabolomics using HILIC-TOF-MS in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2005-01. Bioactive Microbial Metabolites in THE JOURNAL OF ANTIBIOTICS
  • 2009-08. Metabolic quenching of Corynebacterium glutamicum: efficiency of methods and impact of cold shock in BIOPROCESS AND BIOSYSTEMS ENGINEERING
  • 2004-11. A common open representation of mass spectrometry data and its application to proteomics research in NATURE BIOTECHNOLOGY
  • 2012-05. A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue in NATURE PROTOCOLS
  • 2007-12. Normalization method for metabolomics data using optimal selection of multiple internal standards in BMC BIOINFORMATICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00216-014-8127-7

    DOI

    http://dx.doi.org/10.1007/s00216-014-8127-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008816285

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25216964


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