An innovative, easily fabricated, silver nanoparticle-based titanium implant coating: development and analytical characterization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08-29

AUTHORS

E. De Giglio, D. Cafagna, S. Cometa, A. Allegretta, A. Pedico, L. C. Giannossa, L. Sabbatini, M. Mattioli-Belmonte, R. Iatta

ABSTRACT

Microbial colonization and biofilm formation on implanted devices represent an important complication in orthopaedic and dental surgery and may result in implant failure. Controlled release of antibacterial agents directly at the implant site may represent an effective approach to treat these chronic complications. Resistance to conventional antibiotics by pathogenic bacteria has emerged in recent years as a major problem of public health. In order to overcome this problem, non-conventional antimicrobial agents have been under investigation. In this study, polyacrylate-based hydrogel thin coatings have been electrosynthesised on titanium substrates starting from poly(ethylene glycol diacrylate)–co–acrylic acid. Silver nanoparticles (AgNPs) with a narrow size distribution have been synthesized using a “green” procedure and immobilized on Ti implant surfaces exploiting hydrogel coatings’ swelling capabilities. The coatings have been characterized by XPS and SEM/EDX, while their silver release performances have been monitored by ICP–MS. The antibacterial activity of these AgNP-modified hydrogel coatings was tested evaluating in vitro inhibition growth of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, among the most common pathogens in orthopaedic infections. Moreover, a preliminary investigation of the biocompatibility of silver-loaded coatings versus MG63 human osteoblast-like cells has been performed. An important point of strength of this paper, in fact, is the concern about the effect of silver species on the surrounding cell system in implanted medical devices. Silver ion release has been properly tuned in order to assure antibacterial activity while preserving osteoblasts’ response at the implant interface.FigureSilver nanoparticles-loaded PEGDA-AA hydrogel coatings for inhibition of titanium implants associated infections More... »

PAGES

805-816

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00216-012-6293-z

DOI

http://dx.doi.org/10.1007/s00216-012-6293-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026341590

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22926126


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103 non-conventional antimicrobial agents
104 order
105 orthopedic infections
106 osteoblast-like cells
107 osteoblasts
108 paper
109 pathogenic bacteria
110 pathogens
111 performance
112 point
113 preliminary investigation
114 problem
115 procedure
116 public health
117 recent years
118 release
119 release performance
120 resistance
121 response
122 silver ion release
123 silver nanoparticles
124 silver species
125 sites
126 size distribution
127 species
128 strength
129 study
130 substrate
131 surface
132 surgery
133 system
134 thin coatings
135 titanium implants
136 titanium substrate
137 years
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