Comparison of AOAC 2005.06 LC official method with other methodologies for the quantitation of paralytic shellfish poisoning toxins in UK ... View Full Text


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Article Info

DATE

2010-11-27

AUTHORS

Andrew D. Turner, Robert G. Hatfield, Monika Rapkova, Wendy Higman, Myriam Algoet, Benjamin A. Suarez-Isla, Marco Cordova, Catherine Caceres, Jeffrey van de Riet, Ryan Gibbs, Krista Thomas, Michael Quilliam, David N. Lees

ABSTRACT

A refined version of the pre-column oxidation liquid chromatography with fluorescence detection (ox-LC-FLD) official method AOAC 2005.06 was developed in the UK and validated for the determination of paralytic shellfish poisoning toxins in UK shellfish. Analysis was undertaken here for the comparison of PSP toxicities determined using the LC method for a range of UK bivalve shellfish species against the official European reference method, the PSP mouse bioassay (MBA, AOAC 959.08). Comparative results indicated a good correlation in results for some species (mussels, cockles and clams) but a poor correlation for two species of oysters (Pacific oysters and native oysters), where the LC results in terms of total saxitoxin equivalents were found to be on average more than double the values determined by MBA. With the potential for either LC over-estimation or MBA under-estimation, additional oyster and mussel samples were analysed using MBA and ox-LC-FLD together with further analytical and functional methodologies: a post-column oxidation LC method (LC-ox-FLD), an electrophysiological assay and hydrophilic interaction liquid chromatography with tandem mass spectrometric detection. Results highlighted a good correlation among non-bioassay results, indicating a likely cause of difference was the under-estimation in the MBA, rather than an over-estimation in the LC results.FigureTotal saxitoxin equivalents in oysters (Pacific and native) quantified by ox-LC-FLD, LC-ox-FLD, HPLC-MS/MS and electrophysiological assay as compared with the MBA PSP toxicity reference method More... »

PAGES

1257-1270

References to SciGraph publications

  • 2010. Phycotoxins: chemistry, mechanisms of action and shellfish poisoning in MOLECULAR, CLINICAL AND ENVIRONMENTAL TOXICOLOGY
  • 1995-12. Standardized extraction method for paralytic shellfish toxins in phytoplankton in JOURNAL OF APPLIED PHYCOLOGY
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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21113579


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    89 saxitoxin equivalents
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    91 shellfish species
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    95 tandem mass spectrometric detection
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