Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

Jeroen Kool, Martin Giera, Hubertus Irth, Wilfried M. A. Niessen

ABSTRACT

In the screening of complex mixtures, for example combinatorial libraries, natural extracts, and metabolic incubations, different approaches are used for integrated bioaffinity screening. Four major strategies can be used for screening of bioactive mixtures for protein targets-pre-column and post-column off-line, at-line, and on-line strategies. The focus of this review is on recent developments in post-column on-line screening, and the role of mass spectrometry (MS) in these systems. On-line screening systems integrate separation sciences, mass spectrometry, and biochemical methodology, enabling screening for active compounds in complex mixtures. There are three main variants of on-line MS based bioassays: the mass spectrometer is used for ligand identification only; the mass spectrometer is used for both ligand identification and bioassay readout; or MS detection is conducted in parallel with at-line microfractionation with off-line bioaffinity analysis. On the basis of the different fields of application of on-line screening, the principles are explained and their usefulness in the different fields of drug research is critically evaluated. Furthermore, off-line screening is discussed briefly with the on-line and at-line approaches. More... »

PAGES

2655-2668

References to SciGraph publications

  • 2005-08. Monitoring enzymatic conversions by mass spectrometry: a critical review in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2008-01. Real-time mass spectrometry in enzymology in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2007. LC-MALDI MS and MS/MS — An Efficient Tool in Proteome Analysis in SUBCELLULAR PROTEOMICS
  • 2008-04. How to confirm identified toxicants in effect-directed analysis in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2007-01. Effect-Directed Analysis of Key Toxicants in European River Basins. A Review (9 pp) in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2010-10. Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC–HR-MS in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2011-03. Recent developments in protein–ligand affinity mass spectrometry in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2004-10. HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2008-12. Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates in NATURE PROTOCOLS
  • 2009-06-06. High-Throughput Screening of the Cyclic AMP-Dependent Protein Kinase (PKA) Using the Caliper Microfluidic Platform in HIGH THROUGHPUT SCREENING
  • 2008-04. Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2010-02. Effect-related monitoring: estrogen-like substances in groundwater in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2006-08. Design considerations for high speed quantitative mass spectrometry with MALDI ionization in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00216-010-4406-0

    DOI

    http://dx.doi.org/10.1007/s00216-010-4406-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040898258

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21107824


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0301", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Analytical Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biological Assay", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Complex Mixtures", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mass Spectrometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "VU University Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.12380.38", 
              "name": [
                "BioMolecular Analysis, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081, Amsterdam, HV, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kool", 
            "givenName": "Jeroen", 
            "id": "sg:person.0611100247.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611100247.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.12380.38", 
              "name": [
                "BioMolecular Analysis, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081, Amsterdam, HV, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giera", 
            "givenName": "Martin", 
            "id": "sg:person.01151300313.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151300313.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.12380.38", 
              "name": [
                "BioMolecular Analysis, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081, Amsterdam, HV, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Irth", 
            "givenName": "Hubertus", 
            "id": "sg:person.01324510633.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324510633.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.12380.38", 
              "name": [
                "BioMolecular Analysis, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081, Amsterdam, HV, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niessen", 
            "givenName": "Wilfried M. A.", 
            "id": "sg:person.01315356155.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315356155.22"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0021-9673(93)83138-i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001099730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0021-9673(96)00620-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001914562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057107299527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002745958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057107299527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002745958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jchromb.2010.01.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003156875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trac.2009.03.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003669677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chroma.2009.03.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005427397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.aca.2008.04.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006726859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/rcm.4534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007116524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/rcm.4534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007116524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007322451", 
              "https://doi.org/10.1038/nprot.2008.182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200800454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008214845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jchromb.2007.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009244912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmc.2008.11.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010471050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.envpol.2009.12.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012012011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2009.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012523723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057106286653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012627251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057106286653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012627251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.copbio.2005.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013248636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-008-1833-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014507514", 
              "https://doi.org/10.1007/s00216-008-1833-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-008-1833-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014507514", 
              "https://doi.org/10.1007/s00216-008-1833-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.21697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015244277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cmdc.200500038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016510305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cmdc.200500038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016510305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phytochem.2003.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017982616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-4347(98)00119-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018313911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/9783527623259.ch17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018372108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chroma.2003.08.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020271296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chroma.2003.08.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020271296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11356-009-0234-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020333428", 
              "https://doi.org/10.1007/s11356-009-0234-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11356-009-0234-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020333428", 
              "https://doi.org/10.1007/s11356-009-0234-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chroma.2006.01.059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021232063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopha.2007.06.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022145950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chroma.2005.08.081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022166209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chroma.2005.08.081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022166209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0021-9673(97)00646-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022627897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-004-2795-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022692264", 
              "https://doi.org/10.1007/s00216-004-2795-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-004-2795-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022692264", 
              "https://doi.org/10.1007/s00216-004-2795-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.jasms.2006.04.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023332120", 
              "https://doi.org/10.1016/j.jasms.2006.04.026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.jasms.2006.04.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023332120", 
              "https://doi.org/10.1016/j.jasms.2006.04.026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4020-5943-8_17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024217754", 
              "https://doi.org/10.1007/978-1-4020-5943-8_17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4020-5943-8_17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024217754", 
              "https://doi.org/10.1007/978-1-4020-5943-8_17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cmdc.200900201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024810945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cmdc.200900201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024810945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-005-3305-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025129481", 
              "https://doi.org/10.1007/s00216-005-3305-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-005-3305-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025129481", 
              "https://doi.org/10.1007/s00216-005-3305-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/9783527610907.ch5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026477421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tim.2007.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027667138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-010-4087-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028661253", 
              "https://doi.org/10.1007/s00216-010-4087-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-010-4087-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028661253", 
              "https://doi.org/10.1007/s00216-010-4087-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pca.695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029344023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.106.010355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030561197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057103255973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031718594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057103255973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031718594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-60327-258-2_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032321217", 
              "https://doi.org/10.1007/978-1-60327-258-2_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-60327-258-2_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032321217", 
              "https://doi.org/10.1007/978-1-60327-258-2_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1065/espr2006.08.329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033228717", 
              "https://doi.org/10.1065/espr2006.08.329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/108705710100600503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033757939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/108705710100600503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033757939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmc.2009.09.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033954343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mrrev.2005.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034575330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057108326663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034810001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057108326663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034810001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0045-6535(01)00340-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035497144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0021-9673(97)89244-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035893244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0021-9673(93)83066-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037572565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b506559c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039103721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b506559c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039103721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057107301320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040748523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057107301320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040748523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0003-2697(03)00038-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042841776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0003-2697(03)00038-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042841776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057107300647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046115517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057107300647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046115517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-007-1808-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047195463", 
              "https://doi.org/10.1007/s00216-007-1808-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-007-1808-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047195463", 
              "https://doi.org/10.1007/s00216-007-1808-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0021-9673(99)01292-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048201076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-010-4350-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049636287", 
              "https://doi.org/10.1007/s00216-010-4350-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-007-1646-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049786456", 
              "https://doi.org/10.1007/s00216-007-1646-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-007-1646-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049786456", 
              "https://doi.org/10.1007/s00216-007-1646-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057108326143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050614998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057108326143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050614998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jpba.2010.01.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051222063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057110363824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051745862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057110363824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051745862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chroma.2006.05.085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051788923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jpba.2010.04.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052437581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2010.02.107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053133722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057104269731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053790161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057104269731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053790161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac00222a005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054981579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac010026o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054992270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac010026o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054992270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac026423w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054994480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac026423w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054994480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0341822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054994981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0341822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054994981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0349476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0349476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac035380w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac035380w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0506130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054997051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0506130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054997051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0510282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054997247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0510282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054997247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac801035e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055070186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac801035e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055070186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac900622b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055071210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac900622b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055071210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac950736s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055072277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac950736s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055072277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac991202k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055077506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac991202k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055077506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cc020042e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055227549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cc020042e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055227549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm0507936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm0507936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm100230k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055951566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm100230k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055951566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/np9905719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056239976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/np9905719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056239976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/tx7000724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056299543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/tx7000724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056299543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/tx8002593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056299911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/tx8002593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056299911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/154065804323056468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059215743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/adt.2004.2.373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059222073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/adt.2004.2.543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059222091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/adt.2009.0200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059222417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057109355319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063973626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057109355319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063973626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057110362581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063973654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057110362581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063973654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138620709789104924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069174586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138620710791515815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069174650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077971474", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1934578x0900400903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077971474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1934578x0900400903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077971474"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-03", 
        "datePublishedReg": "2011-03-01", 
        "description": "In the screening of complex mixtures, for example combinatorial libraries, natural extracts, and metabolic incubations, different approaches are used for integrated bioaffinity screening. Four major strategies can be used for screening of bioactive mixtures for protein targets-pre-column and post-column off-line, at-line, and on-line strategies. The focus of this review is on recent developments in post-column on-line screening, and the role of mass spectrometry (MS) in these systems. On-line screening systems integrate separation sciences, mass spectrometry, and biochemical methodology, enabling screening for active compounds in complex mixtures. There are three main variants of on-line MS based bioassays: the mass spectrometer is used for ligand identification only; the mass spectrometer is used for both ligand identification and bioassay readout; or MS detection is conducted in parallel with at-line microfractionation with off-line bioaffinity analysis. On the basis of the different fields of application of on-line screening, the principles are explained and their usefulness in the different fields of drug research is critically evaluated. Furthermore, off-line screening is discussed briefly with the on-line and at-line approaches.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00216-010-4406-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1357342", 
            "issn": [
              "1618-2642", 
              "1618-2650"
            ], 
            "name": "Analytical and Bioanalytical Chemistry", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "399"
          }
        ], 
        "name": "Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures", 
        "pagination": "2655-2668", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c2d331b069ab997030e92c1c153ed0daef01037dd2942f0214b0f8fbb8397efe"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21107824"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101134327"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00216-010-4406-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1040898258"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00216-010-4406-0", 
          "https://app.dimensions.ai/details/publication/pub.1040898258"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000515.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00216-010-4406-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00216-010-4406-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00216-010-4406-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00216-010-4406-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00216-010-4406-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      21 PREDICATES      126 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00216-010-4406-0 schema:about N2a06803f69964733a97ff364735dd7e2
    2 N3537623802134ca7b3bef061c51e9c32
    3 N46a3975a0b584a1a8e103224894eea21
    4 N4d275344b0414f69852e24e204ba4abe
    5 N6d64b7f2391d4d54ab9795e11033d5f4
    6 N88fafe06477f469fab27bda598132657
    7 anzsrc-for:03
    8 anzsrc-for:0301
    9 schema:author Nc7bcc3cc623740cd9a334cbf5cef960e
    10 schema:citation sg:pub.10.1007/978-1-4020-5943-8_17
    11 sg:pub.10.1007/978-1-60327-258-2_11
    12 sg:pub.10.1007/s00216-004-2795-7
    13 sg:pub.10.1007/s00216-005-3305-2
    14 sg:pub.10.1007/s00216-007-1646-8
    15 sg:pub.10.1007/s00216-007-1808-8
    16 sg:pub.10.1007/s00216-008-1833-2
    17 sg:pub.10.1007/s00216-010-4087-8
    18 sg:pub.10.1007/s00216-010-4350-z
    19 sg:pub.10.1007/s11356-009-0234-1
    20 sg:pub.10.1016/j.jasms.2006.04.026
    21 sg:pub.10.1038/nprot.2008.182
    22 sg:pub.10.1065/espr2006.08.329
    23 https://app.dimensions.ai/details/publication/pub.1077971474
    24 https://doi.org/10.1002/9783527610907.ch5
    25 https://doi.org/10.1002/9783527623259.ch17
    26 https://doi.org/10.1002/cmdc.200500038
    27 https://doi.org/10.1002/cmdc.200900201
    28 https://doi.org/10.1002/pca.695
    29 https://doi.org/10.1002/pmic.200800454
    30 https://doi.org/10.1002/prot.21697
    31 https://doi.org/10.1002/rcm.4534
    32 https://doi.org/10.1016/0021-9673(93)83066-2
    33 https://doi.org/10.1016/0021-9673(93)83138-i
    34 https://doi.org/10.1016/j.aca.2008.04.017
    35 https://doi.org/10.1016/j.biopha.2007.06.012
    36 https://doi.org/10.1016/j.bmc.2008.11.034
    37 https://doi.org/10.1016/j.bmc.2009.09.037
    38 https://doi.org/10.1016/j.bmcl.2010.02.107
    39 https://doi.org/10.1016/j.chroma.2003.08.055
    40 https://doi.org/10.1016/j.chroma.2005.08.081
    41 https://doi.org/10.1016/j.chroma.2006.01.059
    42 https://doi.org/10.1016/j.chroma.2006.05.085
    43 https://doi.org/10.1016/j.chroma.2009.03.053
    44 https://doi.org/10.1016/j.copbio.2005.10.008
    45 https://doi.org/10.1016/j.envpol.2009.12.032
    46 https://doi.org/10.1016/j.jbiotec.2009.12.005
    47 https://doi.org/10.1016/j.jchromb.2007.08.005
    48 https://doi.org/10.1016/j.jchromb.2010.01.035
    49 https://doi.org/10.1016/j.jpba.2010.01.013
    50 https://doi.org/10.1016/j.jpba.2010.04.015
    51 https://doi.org/10.1016/j.mrrev.2005.02.001
    52 https://doi.org/10.1016/j.phytochem.2003.07.001
    53 https://doi.org/10.1016/j.tim.2007.04.001
    54 https://doi.org/10.1016/j.trac.2009.03.009
    55 https://doi.org/10.1016/s0003-2697(03)00038-1
    56 https://doi.org/10.1016/s0021-9673(96)00620-6
    57 https://doi.org/10.1016/s0021-9673(97)00646-8
    58 https://doi.org/10.1016/s0021-9673(97)89244-8
    59 https://doi.org/10.1016/s0021-9673(99)01292-3
    60 https://doi.org/10.1016/s0045-6535(01)00340-x
    61 https://doi.org/10.1016/s0378-4347(98)00119-4
    62 https://doi.org/10.1021/ac00222a005
    63 https://doi.org/10.1021/ac010026o
    64 https://doi.org/10.1021/ac026423w
    65 https://doi.org/10.1021/ac0341822
    66 https://doi.org/10.1021/ac0349476
    67 https://doi.org/10.1021/ac035380w
    68 https://doi.org/10.1021/ac0506130
    69 https://doi.org/10.1021/ac0510282
    70 https://doi.org/10.1021/ac801035e
    71 https://doi.org/10.1021/ac900622b
    72 https://doi.org/10.1021/ac950736s
    73 https://doi.org/10.1021/ac991202k
    74 https://doi.org/10.1021/cc020042e
    75 https://doi.org/10.1021/jm0507936
    76 https://doi.org/10.1021/jm100230k
    77 https://doi.org/10.1021/np9905719
    78 https://doi.org/10.1021/tx7000724
    79 https://doi.org/10.1021/tx8002593
    80 https://doi.org/10.1039/b506559c
    81 https://doi.org/10.1089/154065804323056468
    82 https://doi.org/10.1089/adt.2004.2.373
    83 https://doi.org/10.1089/adt.2004.2.543
    84 https://doi.org/10.1089/adt.2009.0200
    85 https://doi.org/10.1124/dmd.106.010355
    86 https://doi.org/10.1177/108705710100600503
    87 https://doi.org/10.1177/1087057103255973
    88 https://doi.org/10.1177/1087057104269731
    89 https://doi.org/10.1177/1087057106286653
    90 https://doi.org/10.1177/1087057107299527
    91 https://doi.org/10.1177/1087057107300647
    92 https://doi.org/10.1177/1087057107301320
    93 https://doi.org/10.1177/1087057108326143
    94 https://doi.org/10.1177/1087057108326663
    95 https://doi.org/10.1177/1087057109355319
    96 https://doi.org/10.1177/1087057110362581
    97 https://doi.org/10.1177/1087057110363824
    98 https://doi.org/10.1177/1934578x0900400903
    99 https://doi.org/10.2174/138620709789104924
    100 https://doi.org/10.2174/138620710791515815
    101 schema:datePublished 2011-03
    102 schema:datePublishedReg 2011-03-01
    103 schema:description In the screening of complex mixtures, for example combinatorial libraries, natural extracts, and metabolic incubations, different approaches are used for integrated bioaffinity screening. Four major strategies can be used for screening of bioactive mixtures for protein targets-pre-column and post-column off-line, at-line, and on-line strategies. The focus of this review is on recent developments in post-column on-line screening, and the role of mass spectrometry (MS) in these systems. On-line screening systems integrate separation sciences, mass spectrometry, and biochemical methodology, enabling screening for active compounds in complex mixtures. There are three main variants of on-line MS based bioassays: the mass spectrometer is used for ligand identification only; the mass spectrometer is used for both ligand identification and bioassay readout; or MS detection is conducted in parallel with at-line microfractionation with off-line bioaffinity analysis. On the basis of the different fields of application of on-line screening, the principles are explained and their usefulness in the different fields of drug research is critically evaluated. Furthermore, off-line screening is discussed briefly with the on-line and at-line approaches.
    104 schema:genre research_article
    105 schema:inLanguage en
    106 schema:isAccessibleForFree true
    107 schema:isPartOf N75c3685512184a8394c3df8d2740ef47
    108 N9deea2beac694f87b01ba636e456852b
    109 sg:journal.1357342
    110 schema:name Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures
    111 schema:pagination 2655-2668
    112 schema:productId N55b388f75c7c48788fdfdda82847418c
    113 N6212e83552154fe29ff728d1da8e89aa
    114 N6904dbdcbf324cef8e26795c9d6f0706
    115 N6a70440791f34f50bbb61f5429fa2caf
    116 Nacdd05ded8424465ab68ad9da8291575
    117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040898258
    118 https://doi.org/10.1007/s00216-010-4406-0
    119 schema:sdDatePublished 2019-04-10T19:58
    120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    121 schema:sdPublisher N8253c16bd7ff4846917613df93b59696
    122 schema:url http://link.springer.com/10.1007%2Fs00216-010-4406-0
    123 sgo:license sg:explorer/license/
    124 sgo:sdDataset articles
    125 rdf:type schema:ScholarlyArticle
    126 N2a06803f69964733a97ff364735dd7e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Animals
    128 rdf:type schema:DefinedTerm
    129 N3537623802134ca7b3bef061c51e9c32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Proteins
    131 rdf:type schema:DefinedTerm
    132 N46a3975a0b584a1a8e103224894eea21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Mass Spectrometry
    134 rdf:type schema:DefinedTerm
    135 N4d275344b0414f69852e24e204ba4abe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Complex Mixtures
    137 rdf:type schema:DefinedTerm
    138 N55b388f75c7c48788fdfdda82847418c schema:name doi
    139 schema:value 10.1007/s00216-010-4406-0
    140 rdf:type schema:PropertyValue
    141 N6212e83552154fe29ff728d1da8e89aa schema:name readcube_id
    142 schema:value c2d331b069ab997030e92c1c153ed0daef01037dd2942f0214b0f8fbb8397efe
    143 rdf:type schema:PropertyValue
    144 N6904dbdcbf324cef8e26795c9d6f0706 schema:name pubmed_id
    145 schema:value 21107824
    146 rdf:type schema:PropertyValue
    147 N6a70440791f34f50bbb61f5429fa2caf schema:name nlm_unique_id
    148 schema:value 101134327
    149 rdf:type schema:PropertyValue
    150 N6d64b7f2391d4d54ab9795e11033d5f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Humans
    152 rdf:type schema:DefinedTerm
    153 N75c3685512184a8394c3df8d2740ef47 schema:volumeNumber 399
    154 rdf:type schema:PublicationVolume
    155 N8253c16bd7ff4846917613df93b59696 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 N88fafe06477f469fab27bda598132657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Biological Assay
    159 rdf:type schema:DefinedTerm
    160 N92fdb8ef6c8448958541cf0e744db19b rdf:first sg:person.01315356155.22
    161 rdf:rest rdf:nil
    162 N9deea2beac694f87b01ba636e456852b schema:issueNumber 8
    163 rdf:type schema:PublicationIssue
    164 Nacdd05ded8424465ab68ad9da8291575 schema:name dimensions_id
    165 schema:value pub.1040898258
    166 rdf:type schema:PropertyValue
    167 Nc7bcc3cc623740cd9a334cbf5cef960e rdf:first sg:person.0611100247.78
    168 rdf:rest Ne5a2b034078b4f0f91c3f97bbec3baae
    169 Ne5a2b034078b4f0f91c3f97bbec3baae rdf:first sg:person.01151300313.12
    170 rdf:rest Nec9650bd564e45efb3b1988ce2dbe54a
    171 Nec9650bd564e45efb3b1988ce2dbe54a rdf:first sg:person.01324510633.49
    172 rdf:rest N92fdb8ef6c8448958541cf0e744db19b
    173 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Chemical Sciences
    175 rdf:type schema:DefinedTerm
    176 anzsrc-for:0301 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Analytical Chemistry
    178 rdf:type schema:DefinedTerm
    179 sg:journal.1357342 schema:issn 1618-2642
    180 1618-2650
    181 schema:name Analytical and Bioanalytical Chemistry
    182 rdf:type schema:Periodical
    183 sg:person.01151300313.12 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
    184 schema:familyName Giera
    185 schema:givenName Martin
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151300313.12
    187 rdf:type schema:Person
    188 sg:person.01315356155.22 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
    189 schema:familyName Niessen
    190 schema:givenName Wilfried M. A.
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315356155.22
    192 rdf:type schema:Person
    193 sg:person.01324510633.49 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
    194 schema:familyName Irth
    195 schema:givenName Hubertus
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324510633.49
    197 rdf:type schema:Person
    198 sg:person.0611100247.78 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
    199 schema:familyName Kool
    200 schema:givenName Jeroen
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611100247.78
    202 rdf:type schema:Person
    203 sg:pub.10.1007/978-1-4020-5943-8_17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024217754
    204 https://doi.org/10.1007/978-1-4020-5943-8_17
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/978-1-60327-258-2_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032321217
    207 https://doi.org/10.1007/978-1-60327-258-2_11
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1007/s00216-004-2795-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022692264
    210 https://doi.org/10.1007/s00216-004-2795-7
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/s00216-005-3305-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025129481
    213 https://doi.org/10.1007/s00216-005-3305-2
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/s00216-007-1646-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049786456
    216 https://doi.org/10.1007/s00216-007-1646-8
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s00216-007-1808-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047195463
    219 https://doi.org/10.1007/s00216-007-1808-8
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00216-008-1833-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014507514
    222 https://doi.org/10.1007/s00216-008-1833-2
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00216-010-4087-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028661253
    225 https://doi.org/10.1007/s00216-010-4087-8
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00216-010-4350-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1049636287
    228 https://doi.org/10.1007/s00216-010-4350-z
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s11356-009-0234-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020333428
    231 https://doi.org/10.1007/s11356-009-0234-1
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1016/j.jasms.2006.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023332120
    234 https://doi.org/10.1016/j.jasms.2006.04.026
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nprot.2008.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007322451
    237 https://doi.org/10.1038/nprot.2008.182
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1065/espr2006.08.329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033228717
    240 https://doi.org/10.1065/espr2006.08.329
    241 rdf:type schema:CreativeWork
    242 https://app.dimensions.ai/details/publication/pub.1077971474 schema:CreativeWork
    243 https://doi.org/10.1002/9783527610907.ch5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026477421
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1002/9783527623259.ch17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018372108
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1002/cmdc.200500038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016510305
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1002/cmdc.200900201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024810945
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1002/pca.695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029344023
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1002/pmic.200800454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008214845
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1002/prot.21697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015244277
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1002/rcm.4534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007116524
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/0021-9673(93)83066-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037572565
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/0021-9673(93)83138-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1001099730
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.aca.2008.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006726859
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.biopha.2007.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022145950
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.bmc.2008.11.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010471050
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.bmc.2009.09.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033954343
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.bmcl.2010.02.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053133722
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.chroma.2003.08.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020271296
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.chroma.2005.08.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022166209
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.chroma.2006.01.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021232063
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.chroma.2006.05.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051788923
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.chroma.2009.03.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005427397
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.copbio.2005.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013248636
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.envpol.2009.12.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012012011
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.jbiotec.2009.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012523723
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.jchromb.2007.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009244912
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.jchromb.2010.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003156875
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.jpba.2010.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051222063
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.jpba.2010.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052437581
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.mrrev.2005.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034575330
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.phytochem.2003.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017982616
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.tim.2007.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027667138
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.trac.2009.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003669677
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0003-2697(03)00038-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042841776
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0021-9673(96)00620-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001914562
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s0021-9673(97)00646-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022627897
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0021-9673(97)89244-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035893244
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0021-9673(99)01292-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048201076
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s0045-6535(01)00340-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035497144
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s0378-4347(98)00119-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018313911
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1021/ac00222a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054981579
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1021/ac010026o schema:sameAs https://app.dimensions.ai/details/publication/pub.1054992270
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1021/ac026423w schema:sameAs https://app.dimensions.ai/details/publication/pub.1054994480
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1021/ac0341822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054994981
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1021/ac0349476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054995355
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1021/ac035380w schema:sameAs https://app.dimensions.ai/details/publication/pub.1054995555
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1021/ac0506130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054997051
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1021/ac0510282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054997247
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1021/ac801035e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055070186
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1021/ac900622b schema:sameAs https://app.dimensions.ai/details/publication/pub.1055071210
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1021/ac950736s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055072277
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1021/ac991202k schema:sameAs https://app.dimensions.ai/details/publication/pub.1055077506
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1021/cc020042e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055227549
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1021/jm0507936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055949809
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1021/jm100230k schema:sameAs https://app.dimensions.ai/details/publication/pub.1055951566
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1021/np9905719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056239976
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1021/tx7000724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056299543
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1021/tx8002593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056299911
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1039/b506559c schema:sameAs https://app.dimensions.ai/details/publication/pub.1039103721
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1089/154065804323056468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059215743
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1089/adt.2004.2.373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059222073
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1089/adt.2004.2.543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059222091
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1089/adt.2009.0200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059222417
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1124/dmd.106.010355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030561197
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1177/108705710100600503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033757939
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1177/1087057103255973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031718594
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1177/1087057104269731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053790161
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1177/1087057106286653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012627251
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1177/1087057107299527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002745958
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1177/1087057107300647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046115517
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1177/1087057107301320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040748523
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1177/1087057108326143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050614998
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1177/1087057108326663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034810001
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1177/1087057109355319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063973626
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1177/1087057110362581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063973654
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1177/1087057110363824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051745862
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1177/1934578x0900400903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077971474
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.2174/138620709789104924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069174586
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.2174/138620710791515815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069174650
    396 rdf:type schema:CreativeWork
    397 https://www.grid.ac/institutes/grid.12380.38 schema:alternateName VU University Amsterdam
    398 schema:name BioMolecular Analysis, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081, Amsterdam, HV, The Netherlands
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...