A multivariate approach for the simultaneous determination of losartan potassium and hydrochlorothiazide in a combined pharmaceutical tablet formulation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06-05

AUTHORS

Rubén M. Maggio, Patricia M. Castellano, Teodoro S. Kaufman

ABSTRACT

A convenient new method for the simultaneous determination of losartan potassium and hydrochlorothiazide, with minimum sample pretreatment, is described. The procedure, based on the multivariate analysis of spectral data in the 220−274 nm region by the partial least squares algorithm, is linear in the concentration range 1.06−5.70 mg L−1 for hydrochlorothiazide and 4.0−22.2 mg L−1 for losartan. It is simple, rapid and robust, allowing accurate and precise results, with drug recovery rates of 99.3 and 100.4% and relative standard deviations of 1.7 and 1.0% obtained for hydrochlorothiazide and losartan, respectively. The method was applied to the simultaneous determination of both analytes in tablets, and it provided good results which were in statistical agreement with those provided by independent HPLC analyses of the samples. The method has also been successfully applied for the construction of drug dissolution profiles of a commercial pharmaceutical preparation containing both analytes.FigureA UV-PLS method for the simultaneous determination of losartan potassium and hydrochlorothiazide in pharmaceutical tablet formulations has been developed and validated More... »

PAGES

2949-2955

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00216-008-2180-z

DOI

http://dx.doi.org/10.1007/s00216-008-2180-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002707467

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18528688


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