Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-06-22

AUTHORS

Patricia M. Castellano, Silvana E. Vignaduzzo, Rubén M. Maggio, Teodoro S. Kaufman

ABSTRACT

A new, repeatable, and rapid method has been developed for resolution of binary mixtures of acetaminophen and diclofenac with minimum sample pretreatment and without separation of the analytes. The method, based on the PLS1 processing of absorbance data in the UV region, was successfully used for quantification of the drug content of three tablet preparations. The results obtained were in good agreement with HPLC recovery data. The method also enabled determination of drug-dissolution profiles of these commercial tablets, by simultaneous determination of both analytes during the dissolution test. More... »

PAGES

1711-1714

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00216-005-3314-1

DOI

http://dx.doi.org/10.1007/s00216-005-3314-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032679855

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15971045


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