Synergistic efects of opioid and cannabinoid antagonists on food intake View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-01

AUTHORS

Tim C. Kirkham, Claire M. Williams

ABSTRACT

RATIONALE: Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE: Cannabinoid-opioid interactions in feeding were examined by testing the combined effects on food intake of sub-anorectic doses of selective antagonists for CB1 and opioid receptors. METHODS: Male rats (n = 8) received subcutaneous injections of naloxone (0, 0.1, 0.5, 1.0 mg/kg) and SR141716 (0, 0.1, 0.5, 1.0 mg/kg) before l-h, nocturnal food (chow) intake tests. RESULTS: Neither naloxone nor SR141716 reliably affected feeding when administered alone. By contrast, combined administration of the two antagonists significantly suppressed chow intake at each dose combination. Joint administration of the highest doses of each antagonist suppressed intake by 73%, a significantly greater effect than produced by either naloxone (32%) or SR141716 alone (17%). CONCLUSION: The data reveal a synergistic interaction between the effects of naloxone and SR141716 on feeding, provide further evidence of important functional relationships between endogenous cannabinoid and opioid systems, and strengthen the postulated role for endocannabinoids in reward processes contributing to the normal control of appetite. More... »

PAGES

267-270

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002130000596

DOI

http://dx.doi.org/10.1007/s002130000596

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005415526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11205430


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cannabinoid Receptor Modulators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cannabinoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Synergism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naloxone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Narcotic Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Reading", 
          "id": "https://www.grid.ac/institutes/grid.9435.b", 
          "name": [
            "Department of Psychology, University of Reading, Whiteknights, P.O. Box 238, Reading RG6 6AL, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirkham", 
        "givenName": "Tim C.", 
        "id": "sg:person.0722107666.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722107666.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Reading", 
          "id": "https://www.grid.ac/institutes/grid.9435.b", 
          "name": [
            "Department of Psychology, University of Reading, Whiteknights, P.O. Box 238, Reading RG6 6AL, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Claire M.", 
        "id": "sg:person.016507261262.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016507261262.08"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2001-01", 
    "datePublishedReg": "2001-01-01", 
    "description": "RATIONALE: Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes.\nOBJECTIVE: Cannabinoid-opioid interactions in feeding were examined by testing the combined effects on food intake of sub-anorectic doses of selective antagonists for CB1 and opioid receptors.\nMETHODS: Male rats (n = 8) received subcutaneous injections of naloxone (0, 0.1, 0.5, 1.0 mg/kg) and SR141716 (0, 0.1, 0.5, 1.0 mg/kg) before l-h, nocturnal food (chow) intake tests.\nRESULTS: Neither naloxone nor SR141716 reliably affected feeding when administered alone. By contrast, combined administration of the two antagonists significantly suppressed chow intake at each dose combination. Joint administration of the highest doses of each antagonist suppressed intake by 73%, a significantly greater effect than produced by either naloxone (32%) or SR141716 alone (17%).\nCONCLUSION: The data reveal a synergistic interaction between the effects of naloxone and SR141716 on feeding, provide further evidence of important functional relationships between endogenous cannabinoid and opioid systems, and strengthen the postulated role for endocannabinoids in reward processes contributing to the normal control of appetite.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s002130000596", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085440", 
        "issn": [
          "0033-3158", 
          "1432-2072"
        ], 
        "name": "Psychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "153"
      }
    ], 
    "name": "Synergistic efects of opioid and cannabinoid antagonists on food intake", 
    "pagination": "267-270", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "19cd6ea605f8e4c7c5620fbff048b6a8ecc06cd23a14a25467f3d900ab26a099"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11205430"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7608025"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002130000596"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005415526"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002130000596", 
      "https://app.dimensions.ai/details/publication/pub.1005415526"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs002130000596"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002130000596'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002130000596'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002130000596'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002130000596'


 

This table displays all metadata directly associated to this object as RDF triples.

120 TRIPLES      20 PREDICATES      40 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002130000596 schema:about N368db94b0eae4bb3bb89a11f933369e2
2 N6dafc5936cc4474f8a1eb1f307051384
3 N84f793a7d9704ab4a48266aa1ea03839
4 N862a70311ca649b4ad01ad9b2279f107
5 N8a1178e900844fd1a31b7bec8e8bbf0e
6 Nb3a85f0f7bf846b48d794d32df048424
7 Nc61d39668f7d4601b35f2900797ddd0e
8 Ncf6c482b21e1482099da0d82f80a7a39
9 Ndb407ff4b07741319dc67d1660e0ce57
10 Ned232dbd1a434008ae6e051c00796258
11 Nf006ab7877a84a7b83a2fca34e4737c4
12 anzsrc-for:11
13 anzsrc-for:1115
14 schema:author N9639edcecdf244dcb531571cfb81c80c
15 schema:datePublished 2001-01
16 schema:datePublishedReg 2001-01-01
17 schema:description RATIONALE: Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE: Cannabinoid-opioid interactions in feeding were examined by testing the combined effects on food intake of sub-anorectic doses of selective antagonists for CB1 and opioid receptors. METHODS: Male rats (n = 8) received subcutaneous injections of naloxone (0, 0.1, 0.5, 1.0 mg/kg) and SR141716 (0, 0.1, 0.5, 1.0 mg/kg) before l-h, nocturnal food (chow) intake tests. RESULTS: Neither naloxone nor SR141716 reliably affected feeding when administered alone. By contrast, combined administration of the two antagonists significantly suppressed chow intake at each dose combination. Joint administration of the highest doses of each antagonist suppressed intake by 73%, a significantly greater effect than produced by either naloxone (32%) or SR141716 alone (17%). CONCLUSION: The data reveal a synergistic interaction between the effects of naloxone and SR141716 on feeding, provide further evidence of important functional relationships between endogenous cannabinoid and opioid systems, and strengthen the postulated role for endocannabinoids in reward processes contributing to the normal control of appetite.
18 schema:genre research_article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N469a4ce79cb4418fbc7e6399f9c0723d
22 Nddd16f4fac8c4adcad766ede0e511476
23 sg:journal.1085440
24 schema:name Synergistic efects of opioid and cannabinoid antagonists on food intake
25 schema:pagination 267-270
26 schema:productId N2934317900134923a8734285cf266df8
27 N60d36e7192f04f0cbff988617b6be30b
28 N74776c97c3224dc3b21d2df5ea234550
29 Na7175bc423894d4185e4a70cf773ece1
30 Nf9f30d9a1f8c43d4b69f44ae6ef1ceb7
31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005415526
32 https://doi.org/10.1007/s002130000596
33 schema:sdDatePublished 2019-04-11T01:06
34 schema:sdLicense https://scigraph.springernature.com/explorer/license/
35 schema:sdPublisher N49665d93012e4b6f9a75c98553a18562
36 schema:url http://link.springer.com/10.1007%2Fs002130000596
37 sgo:license sg:explorer/license/
38 sgo:sdDataset articles
39 rdf:type schema:ScholarlyArticle
40 N2934317900134923a8734285cf266df8 schema:name readcube_id
41 schema:value 19cd6ea605f8e4c7c5620fbff048b6a8ecc06cd23a14a25467f3d900ab26a099
42 rdf:type schema:PropertyValue
43 N368db94b0eae4bb3bb89a11f933369e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
44 schema:name Cannabinoids
45 rdf:type schema:DefinedTerm
46 N469a4ce79cb4418fbc7e6399f9c0723d schema:volumeNumber 153
47 rdf:type schema:PublicationVolume
48 N49665d93012e4b6f9a75c98553a18562 schema:name Springer Nature - SN SciGraph project
49 rdf:type schema:Organization
50 N4e8e3b85e934461b8c0bdc87129b21e9 rdf:first sg:person.016507261262.08
51 rdf:rest rdf:nil
52 N60d36e7192f04f0cbff988617b6be30b schema:name nlm_unique_id
53 schema:value 7608025
54 rdf:type schema:PropertyValue
55 N6dafc5936cc4474f8a1eb1f307051384 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Animals
57 rdf:type schema:DefinedTerm
58 N74776c97c3224dc3b21d2df5ea234550 schema:name dimensions_id
59 schema:value pub.1005415526
60 rdf:type schema:PropertyValue
61 N84f793a7d9704ab4a48266aa1ea03839 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Narcotic Antagonists
63 rdf:type schema:DefinedTerm
64 N862a70311ca649b4ad01ad9b2279f107 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Pyrazoles
66 rdf:type schema:DefinedTerm
67 N8a1178e900844fd1a31b7bec8e8bbf0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Drug Synergism
69 rdf:type schema:DefinedTerm
70 N9639edcecdf244dcb531571cfb81c80c rdf:first sg:person.0722107666.98
71 rdf:rest N4e8e3b85e934461b8c0bdc87129b21e9
72 Na7175bc423894d4185e4a70cf773ece1 schema:name pubmed_id
73 schema:value 11205430
74 rdf:type schema:PropertyValue
75 Nb3a85f0f7bf846b48d794d32df048424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Piperidines
77 rdf:type schema:DefinedTerm
78 Nc61d39668f7d4601b35f2900797ddd0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Cannabinoid Receptor Modulators
80 rdf:type schema:DefinedTerm
81 Ncf6c482b21e1482099da0d82f80a7a39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Male
83 rdf:type schema:DefinedTerm
84 Ndb407ff4b07741319dc67d1660e0ce57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Eating
86 rdf:type schema:DefinedTerm
87 Nddd16f4fac8c4adcad766ede0e511476 schema:issueNumber 2
88 rdf:type schema:PublicationIssue
89 Ned232dbd1a434008ae6e051c00796258 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Naloxone
91 rdf:type schema:DefinedTerm
92 Nf006ab7877a84a7b83a2fca34e4737c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Rats
94 rdf:type schema:DefinedTerm
95 Nf9f30d9a1f8c43d4b69f44ae6ef1ceb7 schema:name doi
96 schema:value 10.1007/s002130000596
97 rdf:type schema:PropertyValue
98 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
99 schema:name Medical and Health Sciences
100 rdf:type schema:DefinedTerm
101 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
102 schema:name Pharmacology and Pharmaceutical Sciences
103 rdf:type schema:DefinedTerm
104 sg:journal.1085440 schema:issn 0033-3158
105 1432-2072
106 schema:name Psychopharmacology
107 rdf:type schema:Periodical
108 sg:person.016507261262.08 schema:affiliation https://www.grid.ac/institutes/grid.9435.b
109 schema:familyName Williams
110 schema:givenName Claire M.
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016507261262.08
112 rdf:type schema:Person
113 sg:person.0722107666.98 schema:affiliation https://www.grid.ac/institutes/grid.9435.b
114 schema:familyName Kirkham
115 schema:givenName Tim C.
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722107666.98
117 rdf:type schema:Person
118 https://www.grid.ac/institutes/grid.9435.b schema:alternateName University of Reading
119 schema:name Department of Psychology, University of Reading, Whiteknights, P.O. Box 238, Reading RG6 6AL, UK
120 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...