Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice View Full Text


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Article Info

DATE

2017-07-03

AUTHORS

Maarten van den Buuse, Jac Kee Low, Perrin Kwek, Sally Martin, Andrea Gogos

ABSTRACT

RationaleAltered glutamate NMDA receptor function is implicated in schizophrenia, and gender differences have been demonstrated in this illness.ObjectivesThis study aimed to investigate the interaction of gonadal hormones with NMDA receptor-mediated locomotor hyperactivity and PPI disruption in mice.ResultsThe effect of 0.25 mg/kg of MK-801 on locomotor activity was greater in male mice than in female mice. Gonadectomy (by surgical castration) significantly reduced MK-801-induced hyperlocomotion in male mice, but no effect of gonadectomy was seen in female mice or on amphetamine-induced locomotor hyperactivity. The effect of MK-801 on prepulse inhibition of startle (PPI) was similar in intact and castrated male mice and in ovariectomized (OVX) female mice. In contrast, there was no effect of MK-801 on PPI in intact female mice. Forebrain NMDA receptor density, as measured with [3H]MK-801 autoradiography, was significantly higher in male than in female mice but was not significantly altered by either castration or OVX.ConclusionsThese results suggest that male sex hormones enhance the effect of NMDA receptor blockade on psychosis-like behaviour. This interaction was not seen in female mice and was independent of NMDA receptor density in the forebrain. Male sex hormones may be involved in psychosis by an interaction with NMDA receptor hypofunction. More... »

PAGES

2727-2735

References to SciGraph publications

  • 2015-06-16. Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials in MOLECULAR PSYCHIATRY
  • 2011-07-29. The role of estrogen and testosterone in female rats in behavioral models of relevance to schizophrenia in PSYCHOPHARMACOLOGY
  • 2011-10. Meta-Analysis of the Efficacy of Adjunctive NMDA Receptor Modulators in Chronic Schizophrenia in CNS DRUGS
  • 2015-05-18. Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia in MOLECULAR PSYCHIATRY
  • 2013-08-09. Differential effects of estrogen and testosterone on auditory sensory gating in rats in PSYCHOPHARMACOLOGY
  • 2011-09-28. From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment in NEUROPSYCHOPHARMACOLOGY
  • 2008-06-21. Sex differences and influence of gonadal hormones on MK801-induced neuronal degeneration in the granular retrosplenial cortex of the rat in BRAIN STRUCTURE AND FUNCTION
  • 1995-08-01. Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia in NEUROPSYCHOPHARMACOLOGY
  • 2004-04-28. A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology in BMC MEDICINE
  • 2009-07-14. Psychotropic drug-induced locomotor hyperactivity and prepulse inhibition regulation in male and female aromatase knockout (ArKO) mice: role of dopamine D1 and D2 receptors and dopamine transporters in PSYCHOPHARMACOLOGY
  • 2012-10-16. Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia in MOLECULAR PSYCHIATRY
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    http://scigraph.springernature.com/pub.10.1007/s00213-017-4668-8

    DOI

    http://dx.doi.org/10.1007/s00213-017-4668-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090336242

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28674745


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