Effects of social reorganization on dopamine D2/D3 receptor availability and cocaine self-administration in male cynomolgus monkeys View Full Text


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Article Info

DATE

2017-06-12

AUTHORS

P. W. Czoty, R. W. Gould, H. D. Gage, M. A. Nader

ABSTRACT

RationaleStudies have demonstrated that brain dopamine D2/D3 receptors (D2/D3R) and the reinforcing effects of cocaine can be influenced by a monkey’s position in the social dominance hierarchy.ObjectiveIn this study, we manipulated the social ranks of monkeys by reorganizing social groups and assessed effects on D2/D3R availability and cocaine self-administration.MethodsMale cynomolgus monkeys (N = 12) had been trained to self-administer cocaine under a concurrent cocaine-food reinforcement schedule. Previously, PET measures of D2/D3R availability in the caudate nucleus and putamen had been obtained with [18F]fluoroclebopride during cocaine abstinence, while monkeys lived in stable social groups of four monkeys/pen. For this study, monkeys were reorganized into groups that consisted of (1) four previously dominant, (2) four previously subordinate, and (3) a mix of previously dominant and subordinate monkeys. After 3 months, D2/D3R availability was redetermined and cocaine self-administration was reexamined.ResultsD2/D3R availability significantly increased after reorganization in monkeys who were formerly subordinate, with the greatest increases observed in those that became dominant. No consistent changes in D2/D3R availability were observed in formerly dominant monkeys. Cocaine self-administration did not vary according to rank after reorganization of social groups. However, when compared to their previous cocaine self-administration data, the potency of cocaine as a reinforcer decreased in 9 of 11 monkeys.ConclusionsThese results indicate that changing the social conditions can alter D2/D3R availability in subordinate monkeys in a manner suggestive of environmental enrichment. In most monkeys, social reorganization shifted the cocaine dose-response curve to the right, also consistent with environmental enrichment. More... »

PAGES

2673-2682

References to SciGraph publications

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  • 2012-08-16. Nonhuman primate models of social behavior and cocaine abuse in PSYCHOPHARMACOLOGY
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  • 2004-02-07. Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine in PSYCHOPHARMACOLOGY
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  • 1999-10. PET Imaging of Dopamine D2 Receptors with [18F]Fluoroclebopride in Monkeys: Effects of Isoflurane- and Ketamine-Induced Anesthesia in NEUROPSYCHOPHARMACOLOGY
  • 2015-07-11. Prevention of the incubation of cocaine seeking by aerobic exercise in female rats in PSYCHOPHARMACOLOGY
  • 2014-11-13. Effects of Oral and Intravenous Administration of Buspirone on Food–Cocaine Choice in Socially Housed Male Cynomolgus Monkeys in NEUROPSYCHOPHARMACOLOGY
  • 1999-11. d-Amphetamine ”cue” generalizes to social defeat stress: behavioral sensitization and attenuated accumbens dopamine in PSYCHOPHARMACOLOGY
  • 2010-01-13. Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine in PSYCHOPHARMACOLOGY
  • 2016-12-27. Social Status in Monkeys: Effects of Social Confrontation on Brain Function and Cocaine Self-Administration in NEUROPSYCHOPHARMACOLOGY
  • 1997-04. Acquisition of cocaine self-administration after social stress: role of accumbens dopamine in PSYCHOPHARMACOLOGY
  • 2012-10-28. Rationale in support of the use of selective dopamine D3 receptor antagonists for the pharmacotherapeutic management of substance use disorders in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00213-017-4658-x

    DOI

    http://dx.doi.org/10.1007/s00213-017-4658-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085982085

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28608008


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