Dreamlike effects of LSD on waking imagery in humans depend on serotonin 2A receptor activation View Full Text


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Article Info

DATE

2017-04-07

AUTHORS

Rainer Kraehenmann, Dan Pokorny, Leonie Vollenweider, Katrin H. Preller, Thomas Pokorny, Erich Seifritz, Franz X. Vollenweider

ABSTRACT

RationaleAccumulating evidence indicates that the mixed serotonin and dopamine receptor agonist lysergic acid diethylamide (LSD) induces an altered state of consciousness that resembles dreaming.ObjectivesThis study aimed to test the hypotheses that LSD produces dreamlike waking imagery and that this imagery depends on 5-HT2A receptor activation and is related to subjective drug effects.MethodsTwenty-five healthy subjects performed an audiorecorded guided mental imagery task 7 h after drug administration during three drug conditions: placebo, LSD (100 mcg orally) and LSD together with the 5-HT2A receptor antagonist ketanserin (40 mg orally). Cognitive bizarreness of guided mental imagery reports was quantified as a standardised formal measure of dream mentation. State of consciousness was evaluated using the Altered State of Consciousness (5D-ASC) questionnaire.ResultsLSD, compared with placebo, significantly increased cognitive bizarreness (p < 0.001). The LSD-induced increase in cognitive bizarreness was positively correlated with the LSD-induced loss of self-boundaries and cognitive control (p < 0.05). Both LSD-induced increases in cognitive bizarreness and changes in state of consciousness were fully blocked by ketanserin.ConclusionsLSD produced mental imagery similar to dreaming, primarily via activation of the 5-HT2A receptor and in relation to loss of self-boundaries and cognitive control. Future psychopharmacological studies should assess the differential contribution of the D2/D1 and 5-HT1A receptors to cognitive bizarreness. More... »

PAGES

2031-2046

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00213-017-4610-0

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    33 schema:description RationaleAccumulating evidence indicates that the mixed serotonin and dopamine receptor agonist lysergic acid diethylamide (LSD) induces an altered state of consciousness that resembles dreaming.ObjectivesThis study aimed to test the hypotheses that LSD produces dreamlike waking imagery and that this imagery depends on 5-HT2A receptor activation and is related to subjective drug effects.MethodsTwenty-five healthy subjects performed an audiorecorded guided mental imagery task 7 h after drug administration during three drug conditions: placebo, LSD (100 mcg orally) and LSD together with the 5-HT2A receptor antagonist ketanserin (40 mg orally). Cognitive bizarreness of guided mental imagery reports was quantified as a standardised formal measure of dream mentation. State of consciousness was evaluated using the Altered State of Consciousness (5D-ASC) questionnaire.ResultsLSD, compared with placebo, significantly increased cognitive bizarreness (p < 0.001). The LSD-induced increase in cognitive bizarreness was positively correlated with the LSD-induced loss of self-boundaries and cognitive control (p < 0.05). Both LSD-induced increases in cognitive bizarreness and changes in state of consciousness were fully blocked by ketanserin.ConclusionsLSD produced mental imagery similar to dreaming, primarily via activation of the 5-HT2A receptor and in relation to loss of self-boundaries and cognitive control. Future psychopharmacological studies should assess the differential contribution of the D2/D1 and 5-HT1A receptors to cognitive bizarreness.
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    40 D1
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    42 Drug Administration
    43 LSD-induced increases
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    45 RationaleAccumulating evidence
    46 ResultsLSD
    47 acid diethylamide
    48 activation
    49 administration
    50 altered states
    51 antagonist ketanserin
    52 bizarreness
    53 changes
    54 cognitive bizarreness
    55 cognitive control
    56 conditions
    57 consciousness
    58 contribution
    59 control
    60 diethylamide
    61 differential contribution
    62 dream mentation
    63 dreaming
    64 drug conditions
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    66 effect
    67 evidence
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    69 healthy subjects
    70 humans
    71 hypothesis
    72 imagery
    73 imagery reports
    74 increase
    75 ketanserin
    76 loss
    77 lysergic acid diethylamide
    78 measures
    79 mental imagery
    80 mentation
    81 mixed serotonin
    82 placebo
    83 psychopharmacological studies
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    85 receptor activation
    86 receptor antagonist ketanserin
    87 receptors
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