Tryptophan depletion affects compulsive behaviour in rats: strain dependent effects and associated neuromechanisms View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-09

AUTHORS

A. Merchán, S. V. Navarro, A. B. Klein, S. Aznar, L. Campa, C. Suñol, M. Moreno, P. Flores

ABSTRACT

RationaleCompulsive behaviour, present in different psychiatric disorders, such as obsessive-compulsive disorder, schizophrenia and drug abuse, is associated with altered levels of monoamines, particularly serotonin (5-hydroxytryptamine) and its receptor system.ObjectivesThe present study investigated whether 5-HT manipulation, through a tryptophan (TRP) depletion by diet in Wistar and Lister Hooded rats, modulates compulsive drinking in schedule-induced polydipsia (SIP) and locomotor activity in the open-field test. The levels of dopamine, noradrenaline, serotonin and its metabolite were evaluated, as well as the 5-HT2A and 5-HT1A receptor binding, in different brain regions.MethodsWistar rats were selected as high (HD) or low (LD) drinkers according to their SIP behaviour, while Lister hooded rats did not show SIP acquisition. Both strains were fed for 14 days with either a TRP-free diet (T−) or a TRP-supplemented diet (T+)ResultsThe TRP depletion diet effectively reduced 5-HT levels in the frontal cortex, amygdala and hippocampus in both strains of rats. The TRP-depleted HD Wistar rats were more sensitive to 5-HT manipulation, exhibiting more licks on SIP than did the non-depleted HD Wistar rats, while the LD Wistar and the Lister Hooded rats did not exhibit differences in SIP. In contrast, the TRP-depleted Lister Hooded rats increased locomotor activity compared to the non-depleted rats, while no differences were found in the Wistar rats. Serotonin 2A receptor binding in the striatum was significantly reduced in the TRP-depleted HD Wistar rats.ConclusionsThese results suggest that alterations of the serotonergic system could be involved in compulsive behaviour in vulnerable populations. More... »

PAGES

1223-1236

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00213-017-4561-5

    DOI

    http://dx.doi.org/10.1007/s00213-017-4561-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084019522

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28280881


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