Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04

AUTHORS

Qiufang Bai, Dan Song, Li Gu, Alexei Verkhratsky, Liang Peng

ABSTRACT

OBJECTIVE: Here, we present the data indicating that chronic treatment with fluoxetine regulates Cav-1/PTEN/PI3K/AKT/GSK-3β signalling pathway and glycogen content in primary cultures of astrocytes with bi-phasic concentration dependence. RESULTS: At lower concentrations, fluoxetine downregulates gene expression of Cav-1, decreases membrane content of PTEN, increases activity of PI3K/AKT, and elevates GSK-3β phosphorylation thus suppressing its activity. At higher concentrations, fluoxetine acts in an inverse fashion. As expected, fluoxetine at lower concentrations increased while at higher concentrations decreased glycogen content in astrocytes. CONCLUSIONS: Our findings indicate that bi-phasic regulation of glycogen content via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine may be responsible for both therapeutic and side effects of the drug. More... »

PAGES

1069-1077

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00213-017-4547-3

    DOI

    http://dx.doi.org/10.1007/s00213-017-4547-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083862425

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28233032


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