Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Joshua D. Vardigan, Christopher E. Cannon, Vanita Puri, Mandy Dancho, AmyJo Koser, Marion Wittmann, Scott D. Kuduk, John J. Renger, Jason M. Uslaner

ABSTRACT

RATIONALE: The standards of care for Alzheimer's disease, acetylcholinesterase inhibitors such as donepezil (Aricept®), are dose-limited due to adverse side-effects. These adverse events lead to significant patient non-compliance, constraining the dose and magnitude of efficacy that can be achieved. Non-selective muscarinic receptor orthosteric agonists such as Xanomeline have been shown to be effective in treating symptoms as well, but were also poorly tolerated. Therefore, there is an unmet medical need for a symptomatic treatment that improves symptoms and is better tolerated. METHODS: We compared donepezil, xanomeline, and the novel selective muscarinic 1 receptor positive allosteric modulator PQCA in combination with donepezil in the object retrieval detour (ORD) cognition test in rhesus macaque. Gastrointestinal (GI) side effects (salivation and feces output) were then assessed with all compounds to determine therapeutic window. RESULTS: All three compounds significantly reduced a scopolamine-induced deficit in ORD. Consistent with what is observed clinically in patients, both donepezil and xanomeline produced significant GI effects in rhesus at doses equal to or less than a fivefold margin from the minimum effective dose that improves cognition. In stark contrast, PQCA produced no GI side effects when tested at the same dose range. CONCLUSIONS: These data suggest M1 positive allosteric modulators have the potential to improve cognition in Alzheimer's disease with a greater therapeutic margin than the current standard of care, addressing an important unmet medical need. More... »

PAGES

1859-1866

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00213-014-3813-x

DOI

http://dx.doi.org/10.1007/s00213-014-3813-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034301724

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25491927


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Appetitive Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Attention", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Defecation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca mulatta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscarinic Agonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropsychological Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Orientation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Problem Solving", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyridines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinolizines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Muscarinic M1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Salivation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiadiazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vardigan", 
        "givenName": "Joshua D.", 
        "id": "sg:person.01051374545.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051374545.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cannon", 
        "givenName": "Christopher E.", 
        "id": "sg:person.0612776572.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612776572.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Puri", 
        "givenName": "Vanita", 
        "id": "sg:person.0661111772.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661111772.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dancho", 
        "givenName": "Mandy", 
        "id": "sg:person.01305677572.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305677572.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koser", 
        "givenName": "AmyJo", 
        "id": "sg:person.01325063651.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325063651.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wittmann", 
        "givenName": "Marion", 
        "id": "sg:person.0633546651.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633546651.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuduk", 
        "givenName": "Scott D.", 
        "id": "sg:person.0631151727.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631151727.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Renger", 
        "givenName": "John J.", 
        "id": "sg:person.01357346561.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357346561.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417993.1", 
          "name": [
            "Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uslaner", 
        "givenName": "Jason M.", 
        "id": "sg:person.01111566772.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111566772.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0079-6468(05)43004-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000348462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(01)01057-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001122408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0702201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001795307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002130050672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002218704", 
          "https://doi.org/10.1007/s002130050672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1527-3458.2003.tb00247.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002366825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1527-3458.2003.tb00247.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002366825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(90)91022-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004193365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd006104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005579114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2011.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008158266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002130050865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009672443", 
          "https://doi.org/10.1007/s002130050865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2012.01912.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010135272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00702-006-0579-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013026644", 
          "https://doi.org/10.1007/s00702-006-0579-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00702-006-0579-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013026644", 
          "https://doi.org/10.1007/s00702-006-0579-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0702463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014289543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3930-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015270071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002093-199812000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015419859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002093-199812000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015419859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/334434a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016481567", 
          "https://doi.org/10.1038/334434a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cns.12076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016535451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1974.00490320001001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016959581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd005593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018238335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(97)00075-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018436868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.108.054452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018515649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0028-3932(88)90004-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018711448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0735-7044.103.3.526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019171507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.19.11465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019989107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000255578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020648025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11539810-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022769049", 
          "https://doi.org/10.2165/11539810-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-012-2788-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024676824", 
          "https://doi.org/10.1007/s00213-012-2788-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.102.041616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024708167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200400m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030727024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200400m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030727024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd001190.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031660237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2012.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032093704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0735-7044.104.4.564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032775578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(95)00023-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034391854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2003.11.080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036641225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)16533-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037812313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2004.05.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037990518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.108.141788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039599764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pharmtox.44.101802.121622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039667357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1997.00550160091022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040867172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2008.12.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042414204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(98)00481-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043178861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejme1200429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046134136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15622975.2010.538083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049460451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wad.0b013e31816653bc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049611313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wad.0b013e31816653bc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049611313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(93)90300-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053385092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(93)90300-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053385092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/026988110001400301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053892181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/026988110001400301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053892181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/113.3.617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059438649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7046051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062643340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/cpj.0b013e318278bebd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064351796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/cpj.0b013e318278bebd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064351796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/cpj.0b013e318278bebd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064351796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075253364", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.33588/rn.3605.2002416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075253364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1992.68.6.2264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075679239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.9.8.7768353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082499305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1996.270.1.c131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082948960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083162073", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06", 
    "datePublishedReg": "2015-06-01", 
    "description": "RATIONALE: The standards of care for Alzheimer's disease, acetylcholinesterase inhibitors such as donepezil (Aricept\u00ae), are dose-limited due to adverse side-effects. These adverse events lead to significant patient non-compliance, constraining the dose and magnitude of efficacy that can be achieved. Non-selective muscarinic receptor orthosteric agonists such as Xanomeline have been shown to be effective in treating symptoms as well, but were also poorly tolerated. Therefore, there is an unmet medical need for a symptomatic treatment that improves symptoms and is better tolerated.\nMETHODS: We compared donepezil, xanomeline, and the novel selective muscarinic 1 receptor positive allosteric modulator PQCA in combination with donepezil in the object retrieval detour (ORD) cognition test in rhesus macaque. Gastrointestinal (GI) side effects (salivation and feces output) were then assessed with all compounds to determine therapeutic window.\nRESULTS: All three compounds significantly reduced a scopolamine-induced deficit in ORD. Consistent with what is observed clinically in patients, both donepezil and xanomeline produced significant GI effects in rhesus at doses equal to or less than a fivefold margin from the minimum effective dose that improves cognition. In stark contrast, PQCA produced no GI side effects when tested at the same dose range.\nCONCLUSIONS: These data suggest M1 positive allosteric modulators have the potential to improve cognition in Alzheimer's disease with a greater therapeutic margin than the current standard of care, addressing an important unmet medical need.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00213-014-3813-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085440", 
        "issn": [
          "0033-3158", 
          "1432-2072"
        ], 
        "name": "Psychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "232"
      }
    ], 
    "name": "Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey", 
    "pagination": "1859-1866", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a3664976b2520231b5df560a8ffdc1a79380ed46666d62b22132a9e7e0003df6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25491927"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7608025"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00213-014-3813-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034301724"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00213-014-3813-x", 
      "https://app.dimensions.ai/details/publication/pub.1034301724"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000482.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00213-014-3813-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00213-014-3813-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00213-014-3813-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00213-014-3813-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00213-014-3813-x'


 

This table displays all metadata directly associated to this object as RDF triples.

379 TRIPLES      21 PREDICATES      105 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00213-014-3813-x schema:about N186b19b637614e1fb7c95d63d152d425
2 N1f3da4786fa64c05b3785f06870da915
3 N21fbbb9d11ad4b8ba6b028a0b5d80515
4 N2c307a392a624d6298f0717aeb78756b
5 N3058059314a94745b066cade6bbfb703
6 N38545a2c1b1d4e8eb5c2b5642b6a94f0
7 N3e74595fab8e4c238b5120c4484eb060
8 N43c66f9401bc42faad680da28ab96e42
9 N547d791220fe4851903ae52e84fe9429
10 N66f05164964a4c53a61c976571f900d6
11 N6bd6e9e5e9d54807a6eeb7df1a6721db
12 N95ce41a7fc4a485483efd985ea03372c
13 N9e51d9e3a2174e32856394beba2c83fe
14 Na3c0fda80fed4e5d931eaa8d7680d21f
15 Nba0f11d367d44ea1934a135552a1d7d2
16 Nd6aef4070e3f478a992b0ecbd1941c40
17 Ne0e0d7a166e4487ab0ff85c6984bc2f1
18 Ne71ffe34154b472fa177468824fc541c
19 Neb06849faadf496082f00aa50e33ef10
20 Necf74be197684010be0331777bccb449
21 Nfa35b8d64fab44098bfe137641964628
22 Nfa6376a9616d47c59a995b9de86d80db
23 anzsrc-for:11
24 anzsrc-for:1115
25 schema:author N3b7ffc9bfd1e4df8a2e00568c8ef5a33
26 schema:citation sg:pub.10.1007/s00213-012-2788-8
27 sg:pub.10.1007/s002130050672
28 sg:pub.10.1007/s002130050865
29 sg:pub.10.1007/s00702-006-0579-2
30 sg:pub.10.1038/334434a0
31 sg:pub.10.2165/11539810-000000000-00000
32 https://app.dimensions.ai/details/publication/pub.1075253364
33 https://app.dimensions.ai/details/publication/pub.1083162073
34 https://doi.org/10.1001/archneur.1974.00490320001001
35 https://doi.org/10.1001/archneur.1997.00550160091022
36 https://doi.org/10.1002/14651858.cd001190.pub2
37 https://doi.org/10.1002/14651858.cd005593
38 https://doi.org/10.1002/14651858.cd006104
39 https://doi.org/10.1016/0016-5085(90)91022-x
40 https://doi.org/10.1016/0024-3205(93)90300-r
41 https://doi.org/10.1016/0024-3205(95)00023-y
42 https://doi.org/10.1016/0028-3932(88)90004-8
43 https://doi.org/10.1016/j.ejphar.2003.11.080
44 https://doi.org/10.1016/j.ejphar.2008.12.044
45 https://doi.org/10.1016/j.jalz.2012.01.002
46 https://doi.org/10.1016/j.lfs.2004.05.034
47 https://doi.org/10.1016/j.neuropharm.2011.08.023
48 https://doi.org/10.1016/s0024-3205(01)01057-8
49 https://doi.org/10.1016/s0079-6468(05)43004-0
50 https://doi.org/10.1016/s0140-6736(04)16533-1
51 https://doi.org/10.1016/s0306-4522(97)00075-4
52 https://doi.org/10.1016/s0306-4522(98)00481-3
53 https://doi.org/10.1021/jm200400m
54 https://doi.org/10.1037/0735-7044.103.3.526
55 https://doi.org/10.1037/0735-7044.104.4.564
56 https://doi.org/10.1038/sj.bjp.0702201
57 https://doi.org/10.1038/sj.bjp.0702463
58 https://doi.org/10.1056/nejme1200429
59 https://doi.org/10.1073/pnas.95.19.11465
60 https://doi.org/10.1093/brain/113.3.617
61 https://doi.org/10.1096/fasebj.9.8.7768353
62 https://doi.org/10.1097/00002093-199812000-00010
63 https://doi.org/10.1097/wad.0b013e31816653bc
64 https://doi.org/10.1111/cns.12076
65 https://doi.org/10.1111/j.1365-2982.2012.01912.x
66 https://doi.org/10.1111/j.1527-3458.2003.tb00247.x
67 https://doi.org/10.1124/jpet.102.041616
68 https://doi.org/10.1124/jpet.108.141788
69 https://doi.org/10.1124/mol.108.054452
70 https://doi.org/10.1126/science.7046051
71 https://doi.org/10.1146/annurev.pharmtox.44.101802.121622
72 https://doi.org/10.1152/ajpcell.1996.270.1.c131
73 https://doi.org/10.1152/jn.1992.68.6.2264
74 https://doi.org/10.1159/000255578
75 https://doi.org/10.1177/026988110001400301
76 https://doi.org/10.1212/cpj.0b013e318278bebd
77 https://doi.org/10.1523/jneurosci.3930-09.2009
78 https://doi.org/10.3109/15622975.2010.538083
79 https://doi.org/10.33588/rn.3605.2002416
80 schema:datePublished 2015-06
81 schema:datePublishedReg 2015-06-01
82 schema:description RATIONALE: The standards of care for Alzheimer's disease, acetylcholinesterase inhibitors such as donepezil (Aricept®), are dose-limited due to adverse side-effects. These adverse events lead to significant patient non-compliance, constraining the dose and magnitude of efficacy that can be achieved. Non-selective muscarinic receptor orthosteric agonists such as Xanomeline have been shown to be effective in treating symptoms as well, but were also poorly tolerated. Therefore, there is an unmet medical need for a symptomatic treatment that improves symptoms and is better tolerated. METHODS: We compared donepezil, xanomeline, and the novel selective muscarinic 1 receptor positive allosteric modulator PQCA in combination with donepezil in the object retrieval detour (ORD) cognition test in rhesus macaque. Gastrointestinal (GI) side effects (salivation and feces output) were then assessed with all compounds to determine therapeutic window. RESULTS: All three compounds significantly reduced a scopolamine-induced deficit in ORD. Consistent with what is observed clinically in patients, both donepezil and xanomeline produced significant GI effects in rhesus at doses equal to or less than a fivefold margin from the minimum effective dose that improves cognition. In stark contrast, PQCA produced no GI side effects when tested at the same dose range. CONCLUSIONS: These data suggest M1 positive allosteric modulators have the potential to improve cognition in Alzheimer's disease with a greater therapeutic margin than the current standard of care, addressing an important unmet medical need.
83 schema:genre research_article
84 schema:inLanguage en
85 schema:isAccessibleForFree false
86 schema:isPartOf N6deb227a84984cb1a17b1bed81718021
87 Nfea9d6be6a7348acb239565f5ce1b3ef
88 sg:journal.1085440
89 schema:name Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey
90 schema:pagination 1859-1866
91 schema:productId N47ea3d64ac3c490eb0bd4c75013c0ed4
92 N6d648d222c2c4a0b816d03e6cde61d58
93 N7c5867b8ea8c44d6ac9b0e95aa6832bc
94 Na1fcb9a35af44574892c5f1e29189dc0
95 Na658f2e2ce914487bdd5a811e9eecf99
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034301724
97 https://doi.org/10.1007/s00213-014-3813-x
98 schema:sdDatePublished 2019-04-10T14:01
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher N002a57a2562f47e48c9c2c1515dd0d1b
101 schema:url http://link.springer.com/10.1007/s00213-014-3813-x
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N002a57a2562f47e48c9c2c1515dd0d1b schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 N186b19b637614e1fb7c95d63d152d425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Quinolizines
109 rdf:type schema:DefinedTerm
110 N190af0b7f56e46ceb8473d721733873e rdf:first sg:person.0631151727.00
111 rdf:rest N8f9d0428aa284fc0a9740dbacd481dc3
112 N1f3da4786fa64c05b3785f06870da915 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Cognition
114 rdf:type schema:DefinedTerm
115 N21fbbb9d11ad4b8ba6b028a0b5d80515 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Receptor, Muscarinic M1
117 rdf:type schema:DefinedTerm
118 N2c307a392a624d6298f0717aeb78756b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Piperidines
120 rdf:type schema:DefinedTerm
121 N3058059314a94745b066cade6bbfb703 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Salivation
123 rdf:type schema:DefinedTerm
124 N38545a2c1b1d4e8eb5c2b5642b6a94f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N3b7ffc9bfd1e4df8a2e00568c8ef5a33 rdf:first sg:person.01051374545.07
128 rdf:rest N70fe206392b448668717391a378c5085
129 N3e74595fab8e4c238b5120c4484eb060 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Neuropsychological Tests
131 rdf:type schema:DefinedTerm
132 N43c66f9401bc42faad680da28ab96e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Male
134 rdf:type schema:DefinedTerm
135 N47ea3d64ac3c490eb0bd4c75013c0ed4 schema:name doi
136 schema:value 10.1007/s00213-014-3813-x
137 rdf:type schema:PropertyValue
138 N542e7a9ba3e2410d9d2c55d5bdd59c66 rdf:first sg:person.0661111772.57
139 rdf:rest N873e58dfade1480a9bd4e1c6f169756b
140 N547d791220fe4851903ae52e84fe9429 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Appetitive Behavior
142 rdf:type schema:DefinedTerm
143 N5960d24d103e4bdbba396df0f0196847 rdf:first sg:person.0633546651.23
144 rdf:rest N190af0b7f56e46ceb8473d721733873e
145 N66f05164964a4c53a61c976571f900d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Macaca mulatta
147 rdf:type schema:DefinedTerm
148 N6bd6e9e5e9d54807a6eeb7df1a6721db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Defecation
150 rdf:type schema:DefinedTerm
151 N6d648d222c2c4a0b816d03e6cde61d58 schema:name nlm_unique_id
152 schema:value 7608025
153 rdf:type schema:PropertyValue
154 N6deb227a84984cb1a17b1bed81718021 schema:issueNumber 11
155 rdf:type schema:PublicationIssue
156 N70fe206392b448668717391a378c5085 rdf:first sg:person.0612776572.05
157 rdf:rest N542e7a9ba3e2410d9d2c55d5bdd59c66
158 N7c5867b8ea8c44d6ac9b0e95aa6832bc schema:name dimensions_id
159 schema:value pub.1034301724
160 rdf:type schema:PropertyValue
161 N873e58dfade1480a9bd4e1c6f169756b rdf:first sg:person.01305677572.53
162 rdf:rest Na89408640155458493f358e82ae8eb10
163 N8f9d0428aa284fc0a9740dbacd481dc3 rdf:first sg:person.01357346561.84
164 rdf:rest Nbbba659641bd4e9abf91d7da6c8c3bb0
165 N95ce41a7fc4a485483efd985ea03372c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Pyridines
167 rdf:type schema:DefinedTerm
168 N9e51d9e3a2174e32856394beba2c83fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Attention
170 rdf:type schema:DefinedTerm
171 Na1fcb9a35af44574892c5f1e29189dc0 schema:name pubmed_id
172 schema:value 25491927
173 rdf:type schema:PropertyValue
174 Na3c0fda80fed4e5d931eaa8d7680d21f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Thiadiazoles
176 rdf:type schema:DefinedTerm
177 Na658f2e2ce914487bdd5a811e9eecf99 schema:name readcube_id
178 schema:value a3664976b2520231b5df560a8ffdc1a79380ed46666d62b22132a9e7e0003df6
179 rdf:type schema:PropertyValue
180 Na89408640155458493f358e82ae8eb10 rdf:first sg:person.01325063651.45
181 rdf:rest N5960d24d103e4bdbba396df0f0196847
182 Nba0f11d367d44ea1934a135552a1d7d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Orientation
184 rdf:type schema:DefinedTerm
185 Nbbba659641bd4e9abf91d7da6c8c3bb0 rdf:first sg:person.01111566772.01
186 rdf:rest rdf:nil
187 Nd6aef4070e3f478a992b0ecbd1941c40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Indans
189 rdf:type schema:DefinedTerm
190 Ne0e0d7a166e4487ab0ff85c6984bc2f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Aged
192 rdf:type schema:DefinedTerm
193 Ne71ffe34154b472fa177468824fc541c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Animals
195 rdf:type schema:DefinedTerm
196 Neb06849faadf496082f00aa50e33ef10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Muscarinic Agonists
198 rdf:type schema:DefinedTerm
199 Necf74be197684010be0331777bccb449 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Female
201 rdf:type schema:DefinedTerm
202 Nfa35b8d64fab44098bfe137641964628 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Alzheimer Disease
204 rdf:type schema:DefinedTerm
205 Nfa6376a9616d47c59a995b9de86d80db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Problem Solving
207 rdf:type schema:DefinedTerm
208 Nfea9d6be6a7348acb239565f5ce1b3ef schema:volumeNumber 232
209 rdf:type schema:PublicationVolume
210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
211 schema:name Medical and Health Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
214 schema:name Pharmacology and Pharmaceutical Sciences
215 rdf:type schema:DefinedTerm
216 sg:journal.1085440 schema:issn 0033-3158
217 1432-2072
218 schema:name Psychopharmacology
219 rdf:type schema:Periodical
220 sg:person.01051374545.07 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
221 schema:familyName Vardigan
222 schema:givenName Joshua D.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051374545.07
224 rdf:type schema:Person
225 sg:person.01111566772.01 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
226 schema:familyName Uslaner
227 schema:givenName Jason M.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111566772.01
229 rdf:type schema:Person
230 sg:person.01305677572.53 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
231 schema:familyName Dancho
232 schema:givenName Mandy
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305677572.53
234 rdf:type schema:Person
235 sg:person.01325063651.45 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
236 schema:familyName Koser
237 schema:givenName AmyJo
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325063651.45
239 rdf:type schema:Person
240 sg:person.01357346561.84 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
241 schema:familyName Renger
242 schema:givenName John J.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357346561.84
244 rdf:type schema:Person
245 sg:person.0612776572.05 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
246 schema:familyName Cannon
247 schema:givenName Christopher E.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612776572.05
249 rdf:type schema:Person
250 sg:person.0631151727.00 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
251 schema:familyName Kuduk
252 schema:givenName Scott D.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631151727.00
254 rdf:type schema:Person
255 sg:person.0633546651.23 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
256 schema:familyName Wittmann
257 schema:givenName Marion
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633546651.23
259 rdf:type schema:Person
260 sg:person.0661111772.57 schema:affiliation https://www.grid.ac/institutes/grid.417993.1
261 schema:familyName Puri
262 schema:givenName Vanita
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661111772.57
264 rdf:type schema:Person
265 sg:pub.10.1007/s00213-012-2788-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024676824
266 https://doi.org/10.1007/s00213-012-2788-8
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s002130050672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002218704
269 https://doi.org/10.1007/s002130050672
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s002130050865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009672443
272 https://doi.org/10.1007/s002130050865
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s00702-006-0579-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013026644
275 https://doi.org/10.1007/s00702-006-0579-2
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/334434a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016481567
278 https://doi.org/10.1038/334434a0
279 rdf:type schema:CreativeWork
280 sg:pub.10.2165/11539810-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022769049
281 https://doi.org/10.2165/11539810-000000000-00000
282 rdf:type schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1075253364 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1083162073 schema:CreativeWork
285 https://doi.org/10.1001/archneur.1974.00490320001001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016959581
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1001/archneur.1997.00550160091022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040867172
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1002/14651858.cd001190.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031660237
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1002/14651858.cd005593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018238335
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1002/14651858.cd006104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005579114
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/0016-5085(90)91022-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004193365
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/0024-3205(93)90300-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1053385092
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/0024-3205(95)00023-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034391854
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/0028-3932(88)90004-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018711448
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.ejphar.2003.11.080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036641225
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.ejphar.2008.12.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042414204
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.jalz.2012.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032093704
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.lfs.2004.05.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037990518
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.neuropharm.2011.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008158266
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s0024-3205(01)01057-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001122408
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s0079-6468(05)43004-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000348462
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s0140-6736(04)16533-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037812313
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s0306-4522(97)00075-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018436868
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0306-4522(98)00481-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043178861
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1021/jm200400m schema:sameAs https://app.dimensions.ai/details/publication/pub.1030727024
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1037/0735-7044.103.3.526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019171507
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1037/0735-7044.104.4.564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032775578
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1038/sj.bjp.0702201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001795307
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1038/sj.bjp.0702463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014289543
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1056/nejme1200429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046134136
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1073/pnas.95.19.11465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019989107
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/brain/113.3.617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059438649
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1096/fasebj.9.8.7768353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082499305
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1097/00002093-199812000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015419859
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1097/wad.0b013e31816653bc schema:sameAs https://app.dimensions.ai/details/publication/pub.1049611313
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/cns.12076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016535451
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1111/j.1365-2982.2012.01912.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010135272
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1111/j.1527-3458.2003.tb00247.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002366825
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1124/jpet.102.041616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024708167
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1124/jpet.108.141788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039599764
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1124/mol.108.054452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018515649
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1126/science.7046051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062643340
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1146/annurev.pharmtox.44.101802.121622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039667357
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1152/ajpcell.1996.270.1.c131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082948960
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1152/jn.1992.68.6.2264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075679239
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1159/000255578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020648025
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1177/026988110001400301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053892181
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1212/cpj.0b013e318278bebd schema:sameAs https://app.dimensions.ai/details/publication/pub.1064351796
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1523/jneurosci.3930-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015270071
372 rdf:type schema:CreativeWork
373 https://doi.org/10.3109/15622975.2010.538083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049460451
374 rdf:type schema:CreativeWork
375 https://doi.org/10.33588/rn.3605.2002416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075253364
376 rdf:type schema:CreativeWork
377 https://www.grid.ac/institutes/grid.417993.1 schema:alternateName MSD (United States)
378 schema:name Merck & Co., Inc., WP44E-200 770 Sumneytown Pike, 19486, West Point, PA, USA
379 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...