Risk for antipsychotic-induced extrapyramidal symptoms: influence of family history and genetic susceptibility View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-04

AUTHORS

Meike Kasten, Norbert Brüggemann, Inke R. König, Katja Doerry, Susanne Steinlechner, Liv Wenzel, Katja Lohmann, Christine Klein, Rebekka Lencer

ABSTRACT

OBJECTIVES: This study aims to further evaluate the impact of family history of primary movement disorders (FHpMD) and a candidate genetic variant on risk of antipsychotic-induced extrapyramidal symptoms (EPS). METHODS: We examined 156 (76 men) inpatients receiving antipsychotics for EPS and FHpMD stratified by patient characteristics. The genetic analysis included genotyping of a multiallelic dinucleotide polymorphism in the ATP1A3 gene. RESULTS: EPS lifetime prevalence was 69% and more frequent in the presence of FHpMD (p = 0.052), particularly in patients younger than 60 years (p = 0.012) and with acute dystonic reactions. The ATP1A3 polymorphism showed an allele length-dependent association with parkinsonism (p=0.019 uncorrected, p=0.057 corrected) exclusively. Carriers of the shortest allele had a 7.7-fold increased risk for parkinsonism. CONCLUSIONS: The association of FHpMD and EPS may be linked to the EPS subtype and age of the patient. A common ATP1A3 genomic variation may represent a susceptibility factor for the risk for antipsychotic-induced parkinsonism in an allele-dependent manner. More... »

PAGES

729-736

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00213-010-2079-1

DOI

http://dx.doi.org/10.1007/s00213-010-2079-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003151409

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21072501


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00213-010-2079-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00213-010-2079-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00213-010-2079-1'


 

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