Mice deficient in the alpha subunit of Gz show changes in pre-pulse inhibition, anxiety and responses to 5-HT1A receptor stimulation, ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-08-09

AUTHORS

Maarten van den Buuse, Sally Martin, Joan Holgate, Klaus Matthaei, Ian Hendry

ABSTRACT

RationaleGz, a member of the Gi G protein family, is involved in the coupling of dopaminergic and serotonergic receptors. In the present study, we investigated behaviour of mice deficient in the α subunit of Gz and focused on pre-pulse inhibition (PPI) and anxiety-like responses and the role of serotonin-1A (5-HT1A) receptors.Materials and methodsWe compared male and female wild-type and knock-out mice on either a C57Bl/6 or Balb/c background. We used automated startle boxes to assess startle and PPI and elevated plus maze to assess anxiety-like behaviours.ResultsBalb/c mice showed higher baseline PPI than C57Bl/6 mice, and there was no difference between the genotypes. The 5-HT1A receptor agonist, 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), had no effect on PPI in C57Bl/6 mice but markedly increased PPI in Balb/c mice, with the effect being attenuated in Gαz knock-outs. On the elevated plus maze, there was little effect of the knock-out or 8-OH-DPAT in C57Bl/6 mice, whereas in Balb/c mice, Gαz knock-outs showed a phenotype of high levels of anxiety-like behaviour. 8-OH-DPAT was anxiogenic in Balb/c mice, but this effect was attenuated in Gαz knock-outs.Conclusions5-HT1A receptors couple to Gz. In a strictly background strain-dependent manner, Gαz knock-out mice display high levels of anxiety-like behaviour and are less sensitive to the action of 8-OH-DPAT. Balb/c mice show much more clear effects of the Gαz knock-out than C57Bl/6 mice, which are often considered the standard background strain for genetic modifications. Therefore, our results suggest caution when studying the behavioural effects of genetic modifications only in C57Bl/6 mice. More... »

PAGES

273-283

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00213-007-0888-7

DOI

http://dx.doi.org/10.1007/s00213-007-0888-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034153233

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17684732


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