Up-regulation of cPLA2 gene expression in astrocytes by all three conventional anti-bipolar drugs is drug-specific and enzyme-specific View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Baoman Li, Li Gu, Hongyan Zhang, Jingyang Huang, Ye Chen, Leif Hertz, Liang Peng

ABSTRACT

RATIONALE: Common biological effects by all three conventional anti-bipolar drugs, the lithium ion (Li(+)), carbamazepine, and valproic acid, are important because identical effects may provide information about the pathophysiology of affective disorders. It has been reported that chronic treatment with either drug in vivo down-regulates the turnover of arachidonic acid in brain. This reaction is catalyzed by Ca(2+)-dependent phospholipase A(2) (cPLA(2)), the expression of which was down-regulated by Li(+) or carbamazepine but not by valproic acid; expression of two other PLA subtypes, iPLA(2) and sPLA(2) was unaffected. cPLA(2) is amply expressed in astrocytes, and in the present study, effects of 1-4 weeks of treatment with clinically relevant concentrations of each of the three anti-bipolar drugs on cPLA(2), iPLA(2), and sPLA(2) mRNA and protein expression were determined in primary cultures of mouse astrocytes by reverse transcription polymerase chain reaction (RT-PCR) and immunoblotting. RESULTS: Two or more weeks treatment with Li(+) concentrations below 2 mM, carbamazepine or valproic acid up-regulated mRNA and protein expression of cPLA(2), but had no effect on iPLA(2) and sPLA(2), showing enzyme specificity. The effect occurred more rapidly at higher than lower concentrations but also tended to end after 4 weeks at the higher concentrations. Two millimolar Li(+) caused an initial increase of cPLA(2) followed by a decrease after 3 and 4 weeks. Topiramate had no effect, indicating specificity for anti-bipolar drugs. CONCLUSIONS: Both up- and down-regulation of cPLA(2) gene expression are involved in the mechanisms of action of anti-bipolar drugs; astrocytes are a target for these drugs. More... »

PAGES

333-345

References to SciGraph publications

  • 2005-03. Chronic Lithium Administration to Rats Selectively Modifies 5-HT2A/2C Receptor-Mediated Brain Signaling Via Arachidonic Acid in NEUROPSYCHOPHARMACOLOGY
  • 1991-12. Carbamazepine and its 10,11-epoxide metabolite in acute mania: clinical and pharmacokinetic correlates in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2002-08. Lithium in Bipolar Disorder in CLINICAL PHARMACOKINETICS
  • 2005-10. Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat in PSYCHOPHARMACOLOGY
  • 2000-12. Modifications in phospholipase D activity and isoform expression occur upon maturation and differentiation in vivo and in vitro in human myeloid cells in LEUKEMIA
  • 2002-05. A common mechanism of action for three mood-stabilizing drugs in NATURE
  • 1999-10. Inhibition of the High Affinity Myo-Inositol Transport System: A Common Mechanism of Action of Antibipolar Drugs? in NEUROPSYCHOPHARMACOLOGY
  • 1978-01. Brain concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2002-12. Energy Consumption by Phospholipid Metabolism in Mammalian Brain in NEUROCHEMICAL RESEARCH
  • 1978-02. Kinetic characteristics of the glutamate uptake into normal astrocytes in cultures in NEUROCHEMICAL RESEARCH
  • 1985. Cell Cultures in NEUROCHEMICAL SYSTEMS
  • 2002-02. Up-Regulation of 5-HT2B Receptor Density and Receptor-Mediated Glycogenolysis in Mouse Astrocytes by Long-Term Fluoxetine Administration in NEUROCHEMICAL RESEARCH
  • 2005-02. Phospholipase A2 in astrocytes in MOLECULAR NEUROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00213-007-0853-5

    DOI

    http://dx.doi.org/10.1007/s00213-007-0853-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026707338

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17594078


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