Age-related changes in muscarinic cholinoceptor function in guinea-pig and rat airways View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-08

AUTHORS

J.M.H. Preuss, R.G. Goldie

ABSTRACT

. The influence of age on muscarinic cholinoceptor-mediated contraction and inositol phosphate accumulation was examined in rat and guinea-pig isolated tracheal tissue. Significant age-related changes in the sensitivity of guinea-pig tracheal tissue to acetylcholine, but not carbachol, were observed in the early maturation phase of growth with a 3.3-fold increase in potency between birth and 2 weeks of age followed by a 3.2-fold fall in potency between 2 and 12 weeks of age. Further ageing did not significantly change the potency of acetylcholine or carbachol. Whilst acetylcholinesterase inhibition caused a significant increase in acetylcholine potency, this was independent of animal age. In rat isolated tracheal tissue, contractile responses to both acetylcholine and carbachol remained unchanged with respect to animal age. Significant age-related decreases in inositol phosphate accumulation were observed in response to carbachol in the guinea-pig and rat and to acetylcholine in guinea-pig but not rat isolated tracheal tissue. This study has demonstrated significant age-related changes in the responsiveness of isolated tracheal tissue to carbachol and acetylcholine which were also species-specific. More... »

PAGES

179-186

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002109900052

DOI

http://dx.doi.org/10.1007/s002109900052

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036046641

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10494888


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetylcholine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carbachol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholinesterase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetinae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inositol Phosphates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Muscarinic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trachea", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University of Western Australia, Nedlands, Perth, 6907, Western Australia", 
          "id": "http://www.grid.ac/institutes/grid.1012.2", 
          "name": [
            "Department of Pharmacology, University of Western Australia, Nedlands, Perth, 6907, Western Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Preuss", 
        "givenName": "J.M.H.", 
        "id": "sg:person.01063553541.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063553541.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University of Western Australia, Nedlands, Perth, 6907, Western Australia", 
          "id": "http://www.grid.ac/institutes/grid.1012.2", 
          "name": [
            "Department of Pharmacology, University of Western Australia, Nedlands, Perth, 6907, Western Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goldie", 
        "givenName": "R.G.", 
        "id": "sg:person.01227764644.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227764644.43"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1999-08", 
    "datePublishedReg": "1999-08-01", 
    "description": "Abstract. The influence of age on muscarinic cholinoceptor-mediated contraction and inositol phosphate accumulation was examined in rat and guinea-pig isolated tracheal tissue. Significant age-related changes in the sensitivity of guinea-pig tracheal tissue to acetylcholine, but not carbachol, were observed in the early maturation phase of growth with a 3.3-fold increase in potency between birth and 2\u00a0weeks of age followed by a 3.2-fold fall in potency between 2 and 12\u00a0weeks of age. Further ageing did not significantly change the potency of acetylcholine or carbachol. Whilst acetylcholinesterase inhibition caused a significant increase in acetylcholine potency, this was independent of animal age. In rat isolated tracheal tissue, contractile responses to both acetylcholine and carbachol remained unchanged with respect to animal age. Significant age-related decreases in inositol phosphate accumulation were observed in response to carbachol in the guinea-pig and rat and to acetylcholine in guinea-pig but not rat isolated tracheal tissue. This study has demonstrated significant age-related changes in the responsiveness of isolated tracheal tissue to carbachol and acetylcholine which were also species-specific.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s002109900052", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1015404", 
        "issn": [
          "0028-1298", 
          "1432-1912"
        ], 
        "name": "Naunyn-Schmiedeberg's Archives of Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "360"
      }
    ], 
    "keywords": [
      "age-related changes", 
      "inositol phosphate accumulation", 
      "significant age-related changes", 
      "weeks of age", 
      "tracheal tissue", 
      "guinea pig tracheal tissue", 
      "significant age-related decrease", 
      "potency of acetylcholine", 
      "age-related decrease", 
      "influence of age", 
      "animal age", 
      "contractile response", 
      "rat airways", 
      "phosphate accumulation", 
      "carbachol", 
      "acetylcholine potency", 
      "rats", 
      "acetylcholine", 
      "age", 
      "significant increase", 
      "tissue", 
      "acetylcholinesterase inhibition", 
      "potency", 
      "weeks", 
      "early maturation phase", 
      "airway", 
      "response", 
      "birth", 
      "responsiveness", 
      "inhibition", 
      "contraction", 
      "accumulation", 
      "changes", 
      "increase", 
      "maturation phase", 
      "fall", 
      "aging", 
      "decrease", 
      "study", 
      "sensitivity", 
      "function", 
      "growth", 
      "influence", 
      "respect", 
      "phase"
    ], 
    "name": "Age-related changes in muscarinic cholinoceptor function in guinea-pig and rat airways", 
    "pagination": "179-186", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036046641"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002109900052"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10494888"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002109900052", 
      "https://app.dimensions.ai/details/publication/pub.1036046641"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_335.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s002109900052"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002109900052'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002109900052'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002109900052'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002109900052'


 

This table displays all metadata directly associated to this object as RDF triples.

165 TRIPLES      20 PREDICATES      84 URIs      76 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002109900052 schema:about N5d62e9f1c8c0471eaa0e24a0045a172e
2 N76a76327652c4913b9a12d8077354828
3 N862c3f926cd04e65ab2700ab20cbee57
4 N883ddef195ef41c69de251ae6f7ab9c1
5 N8afd618028bc44f399f72004392194a2
6 N9c78ae13677e43b29faa31a0112ca6b4
7 Nac24fee468474626bd85e705ced95a6c
8 Naffc1eb8c37949718827b5b5274f1153
9 Nc16f7f395e864b2083e0171b5f0939a3
10 Nd311445117e145d1bda0764d3b8fbd7c
11 Nde4b740f6b3e4fffb4f43e08c59f633b
12 Nec8fe33a46704dbb9fc550ae7f55ca17
13 Nfaca80f01ab34144a3ba6a7eebe88fd7
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author N52a226c54b6942d3b7c572a6a5d35a04
17 schema:datePublished 1999-08
18 schema:datePublishedReg 1999-08-01
19 schema:description Abstract. The influence of age on muscarinic cholinoceptor-mediated contraction and inositol phosphate accumulation was examined in rat and guinea-pig isolated tracheal tissue. Significant age-related changes in the sensitivity of guinea-pig tracheal tissue to acetylcholine, but not carbachol, were observed in the early maturation phase of growth with a 3.3-fold increase in potency between birth and 2 weeks of age followed by a 3.2-fold fall in potency between 2 and 12 weeks of age. Further ageing did not significantly change the potency of acetylcholine or carbachol. Whilst acetylcholinesterase inhibition caused a significant increase in acetylcholine potency, this was independent of animal age. In rat isolated tracheal tissue, contractile responses to both acetylcholine and carbachol remained unchanged with respect to animal age. Significant age-related decreases in inositol phosphate accumulation were observed in response to carbachol in the guinea-pig and rat and to acetylcholine in guinea-pig but not rat isolated tracheal tissue. This study has demonstrated significant age-related changes in the responsiveness of isolated tracheal tissue to carbachol and acetylcholine which were also species-specific.
20 schema:genre article
21 schema:isAccessibleForFree false
22 schema:isPartOf N22ce96bf5621448faba2bfa78adaad85
23 N269e766074004c80882d276994763a99
24 sg:journal.1015404
25 schema:keywords accumulation
26 acetylcholine
27 acetylcholine potency
28 acetylcholinesterase inhibition
29 age
30 age-related changes
31 age-related decrease
32 aging
33 airway
34 animal age
35 birth
36 carbachol
37 changes
38 contractile response
39 contraction
40 decrease
41 early maturation phase
42 fall
43 function
44 growth
45 guinea pig tracheal tissue
46 increase
47 influence
48 influence of age
49 inhibition
50 inositol phosphate accumulation
51 maturation phase
52 phase
53 phosphate accumulation
54 potency
55 potency of acetylcholine
56 rat airways
57 rats
58 respect
59 response
60 responsiveness
61 sensitivity
62 significant age-related changes
63 significant age-related decrease
64 significant increase
65 study
66 tissue
67 tracheal tissue
68 weeks
69 weeks of age
70 schema:name Age-related changes in muscarinic cholinoceptor function in guinea-pig and rat airways
71 schema:pagination 179-186
72 schema:productId N47b362f045a54846a363daca4ae84a69
73 Nc50f146529244a50901a533e7caa4026
74 Nd34aacac6e3e44c4b81d093b192ca8e5
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036046641
76 https://doi.org/10.1007/s002109900052
77 schema:sdDatePublished 2022-09-02T15:49
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N679ab54fff4b47f7bfd3a5c26b794079
80 schema:url https://doi.org/10.1007/s002109900052
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N22ce96bf5621448faba2bfa78adaad85 schema:volumeNumber 360
85 rdf:type schema:PublicationVolume
86 N269e766074004c80882d276994763a99 schema:issueNumber 2
87 rdf:type schema:PublicationIssue
88 N47b362f045a54846a363daca4ae84a69 schema:name dimensions_id
89 schema:value pub.1036046641
90 rdf:type schema:PropertyValue
91 N52a226c54b6942d3b7c572a6a5d35a04 rdf:first sg:person.01063553541.25
92 rdf:rest Naf5848e6dc6d4e1ebf79e314c70c2fcc
93 N5d62e9f1c8c0471eaa0e24a0045a172e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Cricetinae
95 rdf:type schema:DefinedTerm
96 N679ab54fff4b47f7bfd3a5c26b794079 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N76a76327652c4913b9a12d8077354828 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Male
100 rdf:type schema:DefinedTerm
101 N862c3f926cd04e65ab2700ab20cbee57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Receptors, Muscarinic
103 rdf:type schema:DefinedTerm
104 N883ddef195ef41c69de251ae6f7ab9c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Aging
106 rdf:type schema:DefinedTerm
107 N8afd618028bc44f399f72004392194a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Carbachol
109 rdf:type schema:DefinedTerm
110 N9c78ae13677e43b29faa31a0112ca6b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Muscle Contraction
112 rdf:type schema:DefinedTerm
113 Nac24fee468474626bd85e705ced95a6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cholinesterase Inhibitors
115 rdf:type schema:DefinedTerm
116 Naf5848e6dc6d4e1ebf79e314c70c2fcc rdf:first sg:person.01227764644.43
117 rdf:rest rdf:nil
118 Naffc1eb8c37949718827b5b5274f1153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Trachea
120 rdf:type schema:DefinedTerm
121 Nc16f7f395e864b2083e0171b5f0939a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Acetylcholine
123 rdf:type schema:DefinedTerm
124 Nc50f146529244a50901a533e7caa4026 schema:name pubmed_id
125 schema:value 10494888
126 rdf:type schema:PropertyValue
127 Nd311445117e145d1bda0764d3b8fbd7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Muscle, Smooth
129 rdf:type schema:DefinedTerm
130 Nd34aacac6e3e44c4b81d093b192ca8e5 schema:name doi
131 schema:value 10.1007/s002109900052
132 rdf:type schema:PropertyValue
133 Nde4b740f6b3e4fffb4f43e08c59f633b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Rats
135 rdf:type schema:DefinedTerm
136 Nec8fe33a46704dbb9fc550ae7f55ca17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Inositol Phosphates
138 rdf:type schema:DefinedTerm
139 Nfaca80f01ab34144a3ba6a7eebe88fd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Animals
141 rdf:type schema:DefinedTerm
142 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
143 schema:name Medical and Health Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
146 schema:name Clinical Sciences
147 rdf:type schema:DefinedTerm
148 sg:journal.1015404 schema:issn 0028-1298
149 1432-1912
150 schema:name Naunyn-Schmiedeberg's Archives of Pharmacology
151 schema:publisher Springer Nature
152 rdf:type schema:Periodical
153 sg:person.01063553541.25 schema:affiliation grid-institutes:grid.1012.2
154 schema:familyName Preuss
155 schema:givenName J.M.H.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063553541.25
157 rdf:type schema:Person
158 sg:person.01227764644.43 schema:affiliation grid-institutes:grid.1012.2
159 schema:familyName Goldie
160 schema:givenName R.G.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227764644.43
162 rdf:type schema:Person
163 grid-institutes:grid.1012.2 schema:alternateName Department of Pharmacology, University of Western Australia, Nedlands, Perth, 6907, Western Australia
164 schema:name Department of Pharmacology, University of Western Australia, Nedlands, Perth, 6907, Western Australia
165 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...