Resveratrol-induced apoptosis is associated with regulating the miR-492/CD147 pathway in malignant melanoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-10-03

AUTHORS

Shuang Zhao, Ling Tang, Wangqing Chen, Juan Su, Fangfang Li, Xiang Chen, Lisha Wu

ABSTRACT

Resveratrol (RES) as a natural phytoalexin has anti-tumor effects on various cancers through its pro-apoptotic activities. Our aim was to determine that RES induces apoptosis in melanoma cells by regulating miR-492 resulting in decreased CD147 expression. We treated A375 and SK-MEL-28 melanoma cells via RES at different concentrations and time-points. The results have shown that the inhibition rate of A375 and SK-MEL-28 was significantly increased after RES treatment. Subsequently, we investigated cell apoptosis by flow cytometry, as well as detected apoptotic-associated proteins including PARP, Caspase-3, Bcl-2, and Bax by western blotting. Meanwhile, the expression of miR-492 and CD147 was analyzed. We found that RES remarkably induces apoptosis in melanoma cells, along with an upregulation of miR-492 and the inhibition of CD147 expression. Furthermore, the detection of luciferase reporter activity confirmed that miR-492 could target CD147 mRNA, and transfected with mimic miR-492 in cells reduced CD147 expression. We also performed the rescued experiment by using a miR-492 inhibitor in melanoma cells. The results showed that the ability of induced apoptosis by RES in melanoma cells was to be attenuated via inhibiting miR-492 expression resulting in CD147 augment. Finally, we determined that the effect of RES-induced apoptosis in melanoma cells is associated with, at least in part, its ability to regulate the miR-492/CD147 pathway. More... »

PAGES

797-807

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00210-020-01981-4

DOI

http://dx.doi.org/10.1007/s00210-020-01981-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131400133

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33009925


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