Casticin inhibits esophageal cancer cell proliferation and promotes apoptosis by regulating mitochondrial apoptotic and JNK signaling pathways View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Zhe Qiao, Yao Cheng, Shiyuan Liu, Zhenchuan Ma, Shaomin Li, Wei Zhang

ABSTRACT

Casticin, a flavonoid isolated from Vitex species, has been found to have anti-tumor property in multiple human cancers. The present study aimed to investigate the effect of casticin on the proliferation and apoptosis of esophageal cancer (EC) cells, and further illustrate the underlying mechanisms. In in vitro studies, human EC cell lines TE-1 and ECA-109 were treated with various concentrations of casticin (low-, middle-, and high-dose groups). The results showed that casticin dose-dependently inhibited the proliferation and clonogenicity of EC cells and induced cell cycle arrest in sub-G1 and G2 phases. Furthermore, casticin markedly enhanced EC cell apoptosis as detected by flow cytometry and Hoechst 33342 staining. The level of anti-apoptotic Bcl-2 protein was decreased, while the levels of pro-apoptotic Bax, cleaved-caspase-3, cleaved-caspase-9, and cleaved-PARP were conversely increased in casticin-treated TE-1 and ECA-109 cells. Moreover, casticin decreased the mitochondrial membrane potential and increased the release of mitochondrial cytochrome C into cytoplasm. In addition, the JNK signaling pathway was involved in casticin-medicated anti-proliferation and pro-apoptosis. Cells pretreated with SP600125, a JNK pathway inhibitor, partially abolished the effect of casticin. Finally, the anti-tumor property of casticin was confirmed in in vivo xenograft models. Overall, we provided both in vitro and in vivo evidences that casticin inhibited the proliferation and induced apoptosis of EC cells, and the anti-tumor action of casticin was mediated, in part, by the mitochondrial-dependent apoptosis and the activation of JNK signaling pathway. More... »

PAGES

1-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00210-018-1574-5

DOI

http://dx.doi.org/10.1007/s00210-018-1574-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109991755

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30448926


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.452672.0", 
          "name": [
            "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, 157 Xiwu Road, 710004, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qiao", 
        "givenName": "Zhe", 
        "id": "sg:person.0627037561.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627037561.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.452672.0", 
          "name": [
            "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, 157 Xiwu Road, 710004, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Yao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.452672.0", 
          "name": [
            "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, 157 Xiwu Road, 710004, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Shiyuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.452672.0", 
          "name": [
            "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, 157 Xiwu Road, 710004, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Zhenchuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.452672.0", 
          "name": [
            "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, 157 Xiwu Road, 710004, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Shaomin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.452672.0", 
          "name": [
            "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, 157 Xiwu Road, 710004, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Wei", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ptr.2639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001943787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/abbs/gms013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002394901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35037710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003551467", 
          "https://doi.org/10.1038/35037710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35037710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003551467", 
          "https://doi.org/10.1038/35037710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/etm.2014.1934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003876712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/etm.2014.1934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003876712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-008-0677-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007377810", 
          "https://doi.org/10.1007/s00277-008-0677-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-008-0677-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007377810", 
          "https://doi.org/10.1007/s00277-008-0677-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ptr.2021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011690715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013220552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013220552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7314/apjcp.2014.15.21.9049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019936923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)61305-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022229807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000350098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025400592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/tox.22381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026283855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0035-9203(87)90161-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027471347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2014.1911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030446755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2014.1911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030446755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2015.07.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032622119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12935-016-0377-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032776934", 
          "https://doi.org/10.1186/s12935-016-0377-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12935-016-0377-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032776934", 
          "https://doi.org/10.1186/s12935-016-0377-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0058855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033313773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.55.3.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038657278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35069004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040728755", 
          "https://doi.org/10.1038/35069004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35069004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040728755", 
          "https://doi.org/10.1038/35069004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60643-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050256847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainresrev.2008.12.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051760193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phymed.2007.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052400516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1138825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062455250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2011.1367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071531480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2016.4895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071534602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.9.6.11392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072295719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4251/wjgo.v6.i5.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072402043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joim.2018.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101360146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2018.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103247600"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Casticin, a flavonoid isolated from Vitex species, has been found to have anti-tumor property in multiple human cancers. The present study aimed to investigate the effect of casticin on the proliferation and apoptosis of esophageal cancer (EC) cells, and further illustrate the underlying mechanisms. In in vitro studies, human EC cell lines TE-1 and ECA-109 were treated with various concentrations of casticin (low-, middle-, and high-dose groups). The results showed that casticin dose-dependently inhibited the proliferation and clonogenicity of EC cells and induced cell cycle arrest in sub-G1 and G2 phases. Furthermore, casticin markedly enhanced EC cell apoptosis as detected by flow cytometry and Hoechst 33342 staining. The level of anti-apoptotic Bcl-2 protein was decreased, while the levels of pro-apoptotic Bax, cleaved-caspase-3, cleaved-caspase-9, and cleaved-PARP were conversely increased in casticin-treated TE-1 and ECA-109 cells. Moreover, casticin decreased the mitochondrial membrane potential and increased the release of mitochondrial cytochrome C into cytoplasm. In addition, the JNK signaling pathway was involved in casticin-medicated anti-proliferation and pro-apoptosis. Cells pretreated with SP600125, a JNK pathway inhibitor, partially abolished the effect of casticin. Finally, the anti-tumor property of casticin was confirmed in in vivo xenograft models. Overall, we provided both in vitro and in vivo evidences that casticin inhibited the proliferation and induced apoptosis of EC cells, and the anti-tumor action of casticin was mediated, in part, by the mitochondrial-dependent apoptosis and the activation of JNK signaling pathway.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00210-018-1574-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1015404", 
        "issn": [
          "0028-1298", 
          "1432-1912"
        ], 
        "name": "Naunyn-Schmiedeberg's Archives of Pharmacology", 
        "type": "Periodical"
      }
    ], 
    "name": "Casticin inhibits esophageal cancer cell proliferation and promotes apoptosis by regulating mitochondrial apoptotic and JNK signaling pathways", 
    "pagination": "1-11", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8bf4ddca8e93687d8f22b8d9c10280df5faf383b0b00bba9dd9591737492f698"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30448926"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0326264"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00210-018-1574-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1109991755"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00210-018-1574-5", 
      "https://app.dimensions.ai/details/publication/pub.1109991755"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000266_0000000266/records_39049_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00210-018-1574-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00210-018-1574-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00210-018-1574-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00210-018-1574-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00210-018-1574-5'


 

This table displays all metadata directly associated to this object as RDF triples.

181 TRIPLES      21 PREDICATES      55 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00210-018-1574-5 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N30bd9125e41b43e2a633c8391e520344
4 schema:citation sg:pub.10.1007/s00277-008-0677-3
5 sg:pub.10.1038/35037710
6 sg:pub.10.1038/35069004
7 sg:pub.10.1186/s12935-016-0377-3
8 https://doi.org/10.1002/jnr.22218
9 https://doi.org/10.1002/ptr.2021
10 https://doi.org/10.1002/ptr.2639
11 https://doi.org/10.1002/tox.22381
12 https://doi.org/10.1016/0035-9203(87)90161-1
13 https://doi.org/10.1016/j.brainresrev.2008.12.011
14 https://doi.org/10.1016/j.ejphar.2018.04.016
15 https://doi.org/10.1016/j.intimp.2015.07.041
16 https://doi.org/10.1016/j.joim.2018.03.001
17 https://doi.org/10.1016/j.phymed.2007.01.008
18 https://doi.org/10.1016/s0140-6736(11)61305-6
19 https://doi.org/10.1016/s0140-6736(12)60643-6
20 https://doi.org/10.1093/abbs/gms013
21 https://doi.org/10.1126/science.1138825
22 https://doi.org/10.1159/000350098
23 https://doi.org/10.1371/journal.pone.0058855
24 https://doi.org/10.3322/canjclin.55.3.178
25 https://doi.org/10.3892/etm.2014.1934
26 https://doi.org/10.3892/ol.2014.1911
27 https://doi.org/10.3892/or.2011.1367
28 https://doi.org/10.3892/or.2016.4895
29 https://doi.org/10.4161/cbt.9.6.11392
30 https://doi.org/10.4251/wjgo.v6.i5.112
31 https://doi.org/10.7314/apjcp.2014.15.21.9049
32 schema:datePublished 2019-02
33 schema:datePublishedReg 2019-02-01
34 schema:description Casticin, a flavonoid isolated from Vitex species, has been found to have anti-tumor property in multiple human cancers. The present study aimed to investigate the effect of casticin on the proliferation and apoptosis of esophageal cancer (EC) cells, and further illustrate the underlying mechanisms. In in vitro studies, human EC cell lines TE-1 and ECA-109 were treated with various concentrations of casticin (low-, middle-, and high-dose groups). The results showed that casticin dose-dependently inhibited the proliferation and clonogenicity of EC cells and induced cell cycle arrest in sub-G1 and G2 phases. Furthermore, casticin markedly enhanced EC cell apoptosis as detected by flow cytometry and Hoechst 33342 staining. The level of anti-apoptotic Bcl-2 protein was decreased, while the levels of pro-apoptotic Bax, cleaved-caspase-3, cleaved-caspase-9, and cleaved-PARP were conversely increased in casticin-treated TE-1 and ECA-109 cells. Moreover, casticin decreased the mitochondrial membrane potential and increased the release of mitochondrial cytochrome C into cytoplasm. In addition, the JNK signaling pathway was involved in casticin-medicated anti-proliferation and pro-apoptosis. Cells pretreated with SP600125, a JNK pathway inhibitor, partially abolished the effect of casticin. Finally, the anti-tumor property of casticin was confirmed in in vivo xenograft models. Overall, we provided both in vitro and in vivo evidences that casticin inhibited the proliferation and induced apoptosis of EC cells, and the anti-tumor action of casticin was mediated, in part, by the mitochondrial-dependent apoptosis and the activation of JNK signaling pathway.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf sg:journal.1015404
39 schema:name Casticin inhibits esophageal cancer cell proliferation and promotes apoptosis by regulating mitochondrial apoptotic and JNK signaling pathways
40 schema:pagination 1-11
41 schema:productId N533edc1c10cf4b59b43bda9c20eb6441
42 N7a2af96918864b0b818b79595bc6b6aa
43 Nbcb1c03d94274959923728e50fb493d7
44 Nd6e193758480473c836184807d707560
45 Nf9d8a5218efe4f6abb29043884585129
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109991755
47 https://doi.org/10.1007/s00210-018-1574-5
48 schema:sdDatePublished 2019-04-11T08:08
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher Necf41af9174347bdace39f0619bdcd9a
51 schema:url https://link.springer.com/10.1007%2Fs00210-018-1574-5
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N1b5a053a59ab47fb973e2d92e65dc8a6 rdf:first N978f1867cd2740a0911b6ea2f6a73193
56 rdf:rest Ne91ca1d4809341d1b9d18b3827bd90dd
57 N30bd9125e41b43e2a633c8391e520344 rdf:first sg:person.0627037561.35
58 rdf:rest N80cb9e39dd884536a172d990e285fe67
59 N529a7c2e6359433bb676a4bd84b72903 schema:affiliation https://www.grid.ac/institutes/grid.452672.0
60 schema:familyName Li
61 schema:givenName Shaomin
62 rdf:type schema:Person
63 N533edc1c10cf4b59b43bda9c20eb6441 schema:name pubmed_id
64 schema:value 30448926
65 rdf:type schema:PropertyValue
66 N5ff5be3a5cd242fbadcb4b428436ad6c schema:affiliation https://www.grid.ac/institutes/grid.452672.0
67 schema:familyName Cheng
68 schema:givenName Yao
69 rdf:type schema:Person
70 N6a4f83b1d04f4b749891c9a6b5c34027 rdf:first N87ce0664bf13421fad58b38d76395581
71 rdf:rest rdf:nil
72 N7a2af96918864b0b818b79595bc6b6aa schema:name doi
73 schema:value 10.1007/s00210-018-1574-5
74 rdf:type schema:PropertyValue
75 N80cb9e39dd884536a172d990e285fe67 rdf:first N5ff5be3a5cd242fbadcb4b428436ad6c
76 rdf:rest N1b5a053a59ab47fb973e2d92e65dc8a6
77 N85e34404ec9e4288be9bab75abcfd23f rdf:first N529a7c2e6359433bb676a4bd84b72903
78 rdf:rest N6a4f83b1d04f4b749891c9a6b5c34027
79 N87ce0664bf13421fad58b38d76395581 schema:affiliation https://www.grid.ac/institutes/grid.452672.0
80 schema:familyName Zhang
81 schema:givenName Wei
82 rdf:type schema:Person
83 N95b8aa60c5a34a18b98044446aea3d31 schema:affiliation https://www.grid.ac/institutes/grid.452672.0
84 schema:familyName Ma
85 schema:givenName Zhenchuan
86 rdf:type schema:Person
87 N978f1867cd2740a0911b6ea2f6a73193 schema:affiliation https://www.grid.ac/institutes/grid.452672.0
88 schema:familyName Liu
89 schema:givenName Shiyuan
90 rdf:type schema:Person
91 Nbcb1c03d94274959923728e50fb493d7 schema:name dimensions_id
92 schema:value pub.1109991755
93 rdf:type schema:PropertyValue
94 Nd6e193758480473c836184807d707560 schema:name readcube_id
95 schema:value 8bf4ddca8e93687d8f22b8d9c10280df5faf383b0b00bba9dd9591737492f698
96 rdf:type schema:PropertyValue
97 Ne91ca1d4809341d1b9d18b3827bd90dd rdf:first N95b8aa60c5a34a18b98044446aea3d31
98 rdf:rest N85e34404ec9e4288be9bab75abcfd23f
99 Necf41af9174347bdace39f0619bdcd9a schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 Nf9d8a5218efe4f6abb29043884585129 schema:name nlm_unique_id
102 schema:value 0326264
103 rdf:type schema:PropertyValue
104 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
105 schema:name Biological Sciences
106 rdf:type schema:DefinedTerm
107 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
108 schema:name Biochemistry and Cell Biology
109 rdf:type schema:DefinedTerm
110 sg:journal.1015404 schema:issn 0028-1298
111 1432-1912
112 schema:name Naunyn-Schmiedeberg's Archives of Pharmacology
113 rdf:type schema:Periodical
114 sg:person.0627037561.35 schema:affiliation https://www.grid.ac/institutes/grid.452672.0
115 schema:familyName Qiao
116 schema:givenName Zhe
117 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627037561.35
118 rdf:type schema:Person
119 sg:pub.10.1007/s00277-008-0677-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007377810
120 https://doi.org/10.1007/s00277-008-0677-3
121 rdf:type schema:CreativeWork
122 sg:pub.10.1038/35037710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003551467
123 https://doi.org/10.1038/35037710
124 rdf:type schema:CreativeWork
125 sg:pub.10.1038/35069004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040728755
126 https://doi.org/10.1038/35069004
127 rdf:type schema:CreativeWork
128 sg:pub.10.1186/s12935-016-0377-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032776934
129 https://doi.org/10.1186/s12935-016-0377-3
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1002/jnr.22218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013220552
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1002/ptr.2021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011690715
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1002/ptr.2639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001943787
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1002/tox.22381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026283855
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1016/0035-9203(87)90161-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027471347
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1016/j.brainresrev.2008.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051760193
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1016/j.ejphar.2018.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103247600
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1016/j.intimp.2015.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032622119
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/j.joim.2018.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101360146
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/j.phymed.2007.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052400516
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/s0140-6736(11)61305-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022229807
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/s0140-6736(12)60643-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050256847
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1093/abbs/gms013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002394901
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1126/science.1138825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455250
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1159/000350098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025400592
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1371/journal.pone.0058855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033313773
162 rdf:type schema:CreativeWork
163 https://doi.org/10.3322/canjclin.55.3.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038657278
164 rdf:type schema:CreativeWork
165 https://doi.org/10.3892/etm.2014.1934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003876712
166 rdf:type schema:CreativeWork
167 https://doi.org/10.3892/ol.2014.1911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030446755
168 rdf:type schema:CreativeWork
169 https://doi.org/10.3892/or.2011.1367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071531480
170 rdf:type schema:CreativeWork
171 https://doi.org/10.3892/or.2016.4895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071534602
172 rdf:type schema:CreativeWork
173 https://doi.org/10.4161/cbt.9.6.11392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072295719
174 rdf:type schema:CreativeWork
175 https://doi.org/10.4251/wjgo.v6.i5.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072402043
176 rdf:type schema:CreativeWork
177 https://doi.org/10.7314/apjcp.2014.15.21.9049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019936923
178 rdf:type schema:CreativeWork
179 https://www.grid.ac/institutes/grid.452672.0 schema:alternateName Second Affiliated Hospital of Xi'an Jiaotong University
180 schema:name Department of Thoracic Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, 157 Xiwu Road, 710004, Xi’an, People’s Republic of China
181 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...