Gastroprotective bio-guiding study of fruits from Mimusops balata View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-07-30

AUTHORS

Fabile Schlickmann, Luisa Mota da Silva, Thaise Boeing, Lincon Bordignon Somensi, Lígia de Moura Burci, José Roberto Santin, Valdir Cechinel Filho, Sérgio Faloni de Andrade

ABSTRACT

Mimusops spp. is used as plant-based antiulcer drugs in Indian traditional medicine. In this study, a bio-guiding study of methanolic extracts of Mimusops balata edible fruits was performed to identify an antiulcer gastric compound. The gastric lesions induced by HCl/ethanol in mice were significantly improved by methanolic extract from seed (MESe, 300 mg/kg), but not by methanolic extract from peel (MEPe, 300 mg/kg) or pulp (MEPu, 300 mg/kg), when compared to the vehicle group. Treatment with MESe also decreased gastric ulceration induced by indomethacin. The antiulcerogenic activity of MESe appears to involve the maintainance of GSH levels, reduction of LPO content, inhibition of neutrophil migration (as evidenced by a decrease in the MPO activity) and a potent free radical scavenger activity (IC50 = 3.4 μg/ml). Moreover, MESe decrease the gastric volume, pH, total acidity, and pepsin activity in the gastric juice. Exceptionally, MESe showed a high content of phenolic compound, identified by layer chromatography and Folin–Ciocalteu reagent. Considering the better pharmacological and phytochemical profile, MESe was successively partitioned and resulted in isolation and identification of a constituent, the flavonoid taxifolin, identified by spectroscopic methods (1H, 13C NMR, and HPLC). Taxifolin also inhibited the ulcerogenic effect of HCl/ethanol at a low dose of 1.14 mg/kg and inhibited in vitro H+/K+-ATPase activity by 41 % at a concentration of 100 μg/ml. Taken together, these results evidenced the gastroprotective potential of fruits from M. balata and showed that this effect is exclusive to the seeds. More... »

PAGES

1187-1200

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00210-015-1156-8

DOI

http://dx.doi.org/10.1007/s00210-015-1156-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016473015

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26223420


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34 schema:description Mimusops spp. is used as plant-based antiulcer drugs in Indian traditional medicine. In this study, a bio-guiding study of methanolic extracts of Mimusops balata edible fruits was performed to identify an antiulcer gastric compound. The gastric lesions induced by HCl/ethanol in mice were significantly improved by methanolic extract from seed (MESe, 300 mg/kg), but not by methanolic extract from peel (MEPe, 300 mg/kg) or pulp (MEPu, 300 mg/kg), when compared to the vehicle group. Treatment with MESe also decreased gastric ulceration induced by indomethacin. The antiulcerogenic activity of MESe appears to involve the maintainance of GSH levels, reduction of LPO content, inhibition of neutrophil migration (as evidenced by a decrease in the MPO activity) and a potent free radical scavenger activity (IC50 = 3.4 μg/ml). Moreover, MESe decrease the gastric volume, pH, total acidity, and pepsin activity in the gastric juice. Exceptionally, MESe showed a high content of phenolic compound, identified by layer chromatography and Folin–Ciocalteu reagent. Considering the better pharmacological and phytochemical profile, MESe was successively partitioned and resulted in isolation and identification of a constituent, the flavonoid taxifolin, identified by spectroscopic methods (1H, 13C NMR, and HPLC). Taxifolin also inhibited the ulcerogenic effect of HCl/ethanol at a low dose of 1.14 mg/kg and inhibited in vitro H+/K+-ATPase activity by 41 % at a concentration of 100 μg/ml. Taken together, these results evidenced the gastroprotective potential of fruits from M. balata and showed that this effect is exclusive to the seeds.
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42 GSH levels
43 Gastroprotective bio-guiding study
44 HCl/ethanol
45 Indian traditional medicine
46 LPO content
47 MeSe
48 Mimusops
49 Mimusops balata
50 acidity
51 activity
52 antiulcer drugs
53 antiulcer gastric compound
54 antiulcerogenic activity
55 balata
56 bio-guiding study
57 chromatography
58 compounds
59 concentration
60 constituents
61 content
62 dose
63 drugs
64 edible fruits
65 effect
66 ethanol
67 extracts
68 flavonoid taxifolin
69 free radical scavenger activity
70 fruit
71 gastric compound
72 gastric juice
73 gastric lesions
74 gastric ulceration
75 gastric volume
76 gastroprotective potential
77 group
78 high content
79 identification
80 indomethacin
81 inhibition
82 isolation
83 juice
84 layer chromatography
85 lesions
86 levels
87 low dose
88 maintainance
89 medicine
90 methanolic extract
91 method
92 mice
93 migration
94 neutrophil migration
95 peel
96 pepsin activity
97 phenolic compounds
98 phytochemical profile
99 plant-based antiulcer drugs
100 potent free radical scavenger activity
101 potential
102 profile
103 pulp
104 radical scavenger activity
105 reagents
106 reduction
107 results
108 scavenger activity
109 seeds
110 spectroscopic methods
111 study
112 taxifolin
113 total acidity
114 traditional medicine
115 treatment
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