Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Polygalaceae) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02

AUTHORS

Luiz Carlos Klein, Renan Becker Gandolfi, José Roberto Santin, Marivane Lemos, Valdir Cechinel Filho, Sérgio Faloni de Andrade

ABSTRACT

The present study evaluates the gastroprotective properties of acetone extract, chloroform, and methanol fractions, alpha-spinasterol (1); 1,3-dihydroxy-7-methoxyxanthone (2); and 1,7-dihydroxy-2,3-methylenedioxyxanthone (3) obtained from Polygala cyparissias (Polygalaceae). Gastroprotective assays were performed in mice using ethanol/HCl and nonsteroidal anti-inflammatory drug (NSAID)/bethanechol-induced ulcer models. Chloroformic fraction showed no interesting results. On the other hand, in the ethanol/HCl-induced ulcer model, the treatment using doses of 50, 125, and 250 mg/kg promoted ulcer inhibition of 45.19+/-12.93%, 62.99+/-3.49%, and 67.40+/-4.75% for acetone extract and 43.70+/-5.12%, 64.56+/-5.64%, and 74.49+/-6.13% for methanol fraction. In the model of NSAID/bethanechol-induced ulcer, the ulcer inhibitions in the same doses were 28.12+/-12.45%, 60.16+/-6.58%, and 77.86+/-7.18% for the acetone extract and 46.09+/-6.92%, 67.45+/-4.36%, and 75.00+/-2.92% for the methanol fraction. In view of the antiulcer potential of the acetone extract and its high yield and xanthone content, it was submitted to chromatographic procedures, giving compounds 1-3, which were also evaluated in the ethanol-induced ulcer model. The results showed that at a dose of 50 mg/kg, these compounds reduced the percentage of ulcer by around 71.26+/-9.40%, 81.10+/-5.75%, and 86.22+/-3.42%, for compounds 1, 2, and 3, respectively. The antiulcerogenic activity of P. cyparissias may be attributed, at least in part, to these compounds. More... »

PAGES

121-126

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00210-009-0485-x

DOI

http://dx.doi.org/10.1007/s00210-009-0485-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030594251

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20054524


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents, Non-Steroidal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Ulcer Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bethanechol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ethanol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrochloric Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phytotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Extracts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polygalaceae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stigmasterol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Ulcer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xanthones", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universidade do Vale do Itaja\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412299.5", 
          "name": [
            "Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed, UNIVALI, Rua Uruguai, 458, 88302-202, Itaja\u00ed, Santa Catarina, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klein", 
        "givenName": "Luiz Carlos", 
        "id": "sg:person.01145241155.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145241155.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade do Vale do Itaja\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412299.5", 
          "name": [
            "N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed, UNIVALI, Rua Uruguai, 458, 88302-202, Itaja\u00ed, Santa Catarina, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gandolfi", 
        "givenName": "Renan Becker", 
        "id": "sg:person.01355147052.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355147052.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade do Vale do Itaja\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412299.5", 
          "name": [
            "Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed, UNIVALI, Rua Uruguai, 458, 88302-202, Itaja\u00ed, Santa Catarina, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santin", 
        "givenName": "Jos\u00e9 Roberto", 
        "id": "sg:person.01313753041.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313753041.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade do Vale do Itaja\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412299.5", 
          "name": [
            "Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed, UNIVALI, Rua Uruguai, 458, 88302-202, Itaja\u00ed, Santa Catarina, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lemos", 
        "givenName": "Marivane", 
        "id": "sg:person.01343472605.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343472605.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade do Vale do Itaja\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412299.5", 
          "name": [
            "Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed, UNIVALI, Rua Uruguai, 458, 88302-202, Itaja\u00ed, Santa Catarina, Brazil", 
            "N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed, UNIVALI, Rua Uruguai, 458, 88302-202, Itaja\u00ed, Santa Catarina, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Filho", 
        "givenName": "Valdir Cechinel", 
        "id": "sg:person.014443642245.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014443642245.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade do Vale do Itaja\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412299.5", 
          "name": [
            "Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed, UNIVALI, Rua Uruguai, 458, 88302-202, Itaja\u00ed, Santa Catarina, Brazil", 
            "N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed, UNIVALI, Rua Uruguai, 458, 88302-202, Itaja\u00ed, Santa Catarina, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Andrade", 
        "givenName": "S\u00e9rgio Faloni", 
        "id": "sg:person.0637661664.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637661664.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0031-9422(98)00051-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000740871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cep.2007.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000892019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytochem.2007.04.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007525576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cbi.2009.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010652564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.18.223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013999153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000007703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020567213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2005.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028754905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2005.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028754905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(97)00741-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030802546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phymed.2007.07.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032282354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2042-7158.1987.tb03454.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032771233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12272-008-1118-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035050504", 
          "https://doi.org/10.1007/s12272-008-1118-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2042-7158.1991.tb03461.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035473093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2005.04.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036003554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s000110050449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036127917", 
          "https://doi.org/10.1007/s000110050449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mam.2005.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038428456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mam.2005.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038428456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2007.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042386384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)11030-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046319386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ddmec.2006.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048464720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2004.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051287478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.annepidem.2005.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051745689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.annepidem.2005.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051745689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np50105a012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056236643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/znc-2007-7-812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067584142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078435952", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-02", 
    "datePublishedReg": "2010-02-01", 
    "description": "The present study evaluates the gastroprotective properties of acetone extract, chloroform, and methanol fractions, alpha-spinasterol (1); 1,3-dihydroxy-7-methoxyxanthone (2); and 1,7-dihydroxy-2,3-methylenedioxyxanthone (3) obtained from Polygala cyparissias (Polygalaceae). Gastroprotective assays were performed in mice using ethanol/HCl and nonsteroidal anti-inflammatory drug (NSAID)/bethanechol-induced ulcer models. Chloroformic fraction showed no interesting results. On the other hand, in the ethanol/HCl-induced ulcer model, the treatment using doses of 50, 125, and 250 mg/kg promoted ulcer inhibition of 45.19+/-12.93%, 62.99+/-3.49%, and 67.40+/-4.75% for acetone extract and 43.70+/-5.12%, 64.56+/-5.64%, and 74.49+/-6.13% for methanol fraction. In the model of NSAID/bethanechol-induced ulcer, the ulcer inhibitions in the same doses were 28.12+/-12.45%, 60.16+/-6.58%, and 77.86+/-7.18% for the acetone extract and 46.09+/-6.92%, 67.45+/-4.36%, and 75.00+/-2.92% for the methanol fraction. In view of the antiulcer potential of the acetone extract and its high yield and xanthone content, it was submitted to chromatographic procedures, giving compounds 1-3, which were also evaluated in the ethanol-induced ulcer model. The results showed that at a dose of 50 mg/kg, these compounds reduced the percentage of ulcer by around 71.26+/-9.40%, 81.10+/-5.75%, and 86.22+/-3.42%, for compounds 1, 2, and 3, respectively. The antiulcerogenic activity of P. cyparissias may be attributed, at least in part, to these compounds.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00210-009-0485-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1015404", 
        "issn": [
          "0028-1298", 
          "1432-1912"
        ], 
        "name": "Naunyn-Schmiedeberg's Archives of Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "381"
      }
    ], 
    "name": "Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Polygalaceae)", 
    "pagination": "121-126", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "91bf4c2c559328fbd88f2244e3e62bdae147908c79f5e1584b85870bd2820c62"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20054524"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0326264"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00210-009-0485-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030594251"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00210-009-0485-x", 
      "https://app.dimensions.ai/details/publication/pub.1030594251"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89785_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00210-009-0485-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00210-009-0485-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00210-009-0485-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00210-009-0485-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00210-009-0485-x'


 

This table displays all metadata directly associated to this object as RDF triples.

231 TRIPLES      21 PREDICATES      66 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00210-009-0485-x schema:about N04217680f7bd48a9b3c904b23695abe7
2 N0fdaf06ad880443081f7adc8027df3b8
3 N2e686e2a9857428aa0d773a43defbba4
4 N3369db72a69c47fb9468aeb154ba0dbe
5 N34ae5c3db71c404ebb2253522a45b2b7
6 N4ebba280712b4f3cb438155e6577ac9c
7 Nb19184ffbd1c4f7f98b0e03b83bd7af2
8 Nbc20864d103f4ac6a1d80537df013d48
9 Ncb425c1c5ae4468bae1b9ac3da79dbc8
10 Nd0029fbf20bb4730a2c2cda119e48972
11 Nec82ad89de66456a9f866b3aa057ebe7
12 Nf60b9830ec6a43f697fb904701b19a52
13 Nf8c30bbf8b1b45d69622d610a4e15dca
14 Nfb51290c485c4b48ad3247eaf4aefcab
15 anzsrc-for:11
16 anzsrc-for:1115
17 schema:author N1642ee5f4de54f03981e646a17d2f802
18 schema:citation sg:pub.10.1007/s000110050449
19 sg:pub.10.1007/s12272-008-1118-5
20 https://app.dimensions.ai/details/publication/pub.1078435952
21 https://doi.org/10.1016/j.annepidem.2005.02.004
22 https://doi.org/10.1016/j.cbi.2009.04.001
23 https://doi.org/10.1016/j.cep.2007.08.007
24 https://doi.org/10.1016/j.ddmec.2006.07.001
25 https://doi.org/10.1016/j.jchromb.2004.08.009
26 https://doi.org/10.1016/j.jep.2005.04.027
27 https://doi.org/10.1016/j.lfs.2005.09.012
28 https://doi.org/10.1016/j.lfs.2007.11.007
29 https://doi.org/10.1016/j.mam.2005.07.008
30 https://doi.org/10.1016/j.phymed.2007.07.057
31 https://doi.org/10.1016/j.phytochem.2007.04.032
32 https://doi.org/10.1016/s0024-3205(97)00741-8
33 https://doi.org/10.1016/s0031-9422(98)00051-x
34 https://doi.org/10.1016/s0140-6736(02)11030-0
35 https://doi.org/10.1021/np50105a012
36 https://doi.org/10.1111/j.2042-7158.1987.tb03454.x
37 https://doi.org/10.1111/j.2042-7158.1991.tb03461.x
38 https://doi.org/10.1159/000007703
39 https://doi.org/10.1248/bpb.18.223
40 https://doi.org/10.1515/znc-2007-7-812
41 schema:datePublished 2010-02
42 schema:datePublishedReg 2010-02-01
43 schema:description The present study evaluates the gastroprotective properties of acetone extract, chloroform, and methanol fractions, alpha-spinasterol (1); 1,3-dihydroxy-7-methoxyxanthone (2); and 1,7-dihydroxy-2,3-methylenedioxyxanthone (3) obtained from Polygala cyparissias (Polygalaceae). Gastroprotective assays were performed in mice using ethanol/HCl and nonsteroidal anti-inflammatory drug (NSAID)/bethanechol-induced ulcer models. Chloroformic fraction showed no interesting results. On the other hand, in the ethanol/HCl-induced ulcer model, the treatment using doses of 50, 125, and 250 mg/kg promoted ulcer inhibition of 45.19+/-12.93%, 62.99+/-3.49%, and 67.40+/-4.75% for acetone extract and 43.70+/-5.12%, 64.56+/-5.64%, and 74.49+/-6.13% for methanol fraction. In the model of NSAID/bethanechol-induced ulcer, the ulcer inhibitions in the same doses were 28.12+/-12.45%, 60.16+/-6.58%, and 77.86+/-7.18% for the acetone extract and 46.09+/-6.92%, 67.45+/-4.36%, and 75.00+/-2.92% for the methanol fraction. In view of the antiulcer potential of the acetone extract and its high yield and xanthone content, it was submitted to chromatographic procedures, giving compounds 1-3, which were also evaluated in the ethanol-induced ulcer model. The results showed that at a dose of 50 mg/kg, these compounds reduced the percentage of ulcer by around 71.26+/-9.40%, 81.10+/-5.75%, and 86.22+/-3.42%, for compounds 1, 2, and 3, respectively. The antiulcerogenic activity of P. cyparissias may be attributed, at least in part, to these compounds.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf N23ee92e1bed046ac8438a623245a1c69
48 Ndaf2f10ff4dc4a6cb6cd15f56825a0b9
49 sg:journal.1015404
50 schema:name Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Polygalaceae)
51 schema:pagination 121-126
52 schema:productId N0109409298804c08bdaa63c849f783f8
53 N0cc9ec7f03524bc69f4d28686abdd17c
54 N5a911899afe2487e903edda90f38a025
55 N776b5fb74b98491583625d00e58740ea
56 Nbd223be413fd425888ea49aa1645b29c
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030594251
58 https://doi.org/10.1007/s00210-009-0485-x
59 schema:sdDatePublished 2019-04-11T09:49
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N16a7857af63840089d08dec867a8f8c8
62 schema:url http://link.springer.com/10.1007/s00210-009-0485-x
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N0109409298804c08bdaa63c849f783f8 schema:name readcube_id
67 schema:value 91bf4c2c559328fbd88f2244e3e62bdae147908c79f5e1584b85870bd2820c62
68 rdf:type schema:PropertyValue
69 N04217680f7bd48a9b3c904b23695abe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Xanthones
71 rdf:type schema:DefinedTerm
72 N0653a378748c46b888441a11d965d94c rdf:first sg:person.01313753041.46
73 rdf:rest N5c3f61da351c4d358f93b84b48c0a55e
74 N0cc9ec7f03524bc69f4d28686abdd17c schema:name dimensions_id
75 schema:value pub.1030594251
76 rdf:type schema:PropertyValue
77 N0fdaf06ad880443081f7adc8027df3b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Anti-Inflammatory Agents, Non-Steroidal
79 rdf:type schema:DefinedTerm
80 N1265d25325a548f4acd3b22070abafe2 rdf:first sg:person.01355147052.24
81 rdf:rest N0653a378748c46b888441a11d965d94c
82 N1642ee5f4de54f03981e646a17d2f802 rdf:first sg:person.01145241155.33
83 rdf:rest N1265d25325a548f4acd3b22070abafe2
84 N16a7857af63840089d08dec867a8f8c8 schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N209c489ef8654ede9d17a5101c6c6027 rdf:first sg:person.014443642245.05
87 rdf:rest Na596f32668724b159551f99f02e5c825
88 N23ee92e1bed046ac8438a623245a1c69 schema:volumeNumber 381
89 rdf:type schema:PublicationVolume
90 N2e686e2a9857428aa0d773a43defbba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Stomach Ulcer
92 rdf:type schema:DefinedTerm
93 N3369db72a69c47fb9468aeb154ba0dbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Dose-Response Relationship, Drug
95 rdf:type schema:DefinedTerm
96 N34ae5c3db71c404ebb2253522a45b2b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Hydrochloric Acid
98 rdf:type schema:DefinedTerm
99 N4ebba280712b4f3cb438155e6577ac9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 N5a911899afe2487e903edda90f38a025 schema:name nlm_unique_id
103 schema:value 0326264
104 rdf:type schema:PropertyValue
105 N5c3f61da351c4d358f93b84b48c0a55e rdf:first sg:person.01343472605.08
106 rdf:rest N209c489ef8654ede9d17a5101c6c6027
107 N776b5fb74b98491583625d00e58740ea schema:name doi
108 schema:value 10.1007/s00210-009-0485-x
109 rdf:type schema:PropertyValue
110 Na596f32668724b159551f99f02e5c825 rdf:first sg:person.0637661664.44
111 rdf:rest rdf:nil
112 Nb19184ffbd1c4f7f98b0e03b83bd7af2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Anti-Ulcer Agents
114 rdf:type schema:DefinedTerm
115 Nbc20864d103f4ac6a1d80537df013d48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Ethanol
117 rdf:type schema:DefinedTerm
118 Nbd223be413fd425888ea49aa1645b29c schema:name pubmed_id
119 schema:value 20054524
120 rdf:type schema:PropertyValue
121 Ncb425c1c5ae4468bae1b9ac3da79dbc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Stigmasterol
123 rdf:type schema:DefinedTerm
124 Nd0029fbf20bb4730a2c2cda119e48972 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Bethanechol
126 rdf:type schema:DefinedTerm
127 Ndaf2f10ff4dc4a6cb6cd15f56825a0b9 schema:issueNumber 2
128 rdf:type schema:PublicationIssue
129 Nec82ad89de66456a9f866b3aa057ebe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Polygalaceae
131 rdf:type schema:DefinedTerm
132 Nf60b9830ec6a43f697fb904701b19a52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Phytotherapy
134 rdf:type schema:DefinedTerm
135 Nf8c30bbf8b1b45d69622d610a4e15dca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Plant Extracts
137 rdf:type schema:DefinedTerm
138 Nfb51290c485c4b48ad3247eaf4aefcab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Mice
140 rdf:type schema:DefinedTerm
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
145 schema:name Pharmacology and Pharmaceutical Sciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1015404 schema:issn 0028-1298
148 1432-1912
149 schema:name Naunyn-Schmiedeberg's Archives of Pharmacology
150 rdf:type schema:Periodical
151 sg:person.01145241155.33 schema:affiliation https://www.grid.ac/institutes/grid.412299.5
152 schema:familyName Klein
153 schema:givenName Luiz Carlos
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145241155.33
155 rdf:type schema:Person
156 sg:person.01313753041.46 schema:affiliation https://www.grid.ac/institutes/grid.412299.5
157 schema:familyName Santin
158 schema:givenName José Roberto
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313753041.46
160 rdf:type schema:Person
161 sg:person.01343472605.08 schema:affiliation https://www.grid.ac/institutes/grid.412299.5
162 schema:familyName Lemos
163 schema:givenName Marivane
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343472605.08
165 rdf:type schema:Person
166 sg:person.01355147052.24 schema:affiliation https://www.grid.ac/institutes/grid.412299.5
167 schema:familyName Gandolfi
168 schema:givenName Renan Becker
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355147052.24
170 rdf:type schema:Person
171 sg:person.014443642245.05 schema:affiliation https://www.grid.ac/institutes/grid.412299.5
172 schema:familyName Filho
173 schema:givenName Valdir Cechinel
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014443642245.05
175 rdf:type schema:Person
176 sg:person.0637661664.44 schema:affiliation https://www.grid.ac/institutes/grid.412299.5
177 schema:familyName de Andrade
178 schema:givenName Sérgio Faloni
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637661664.44
180 rdf:type schema:Person
181 sg:pub.10.1007/s000110050449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036127917
182 https://doi.org/10.1007/s000110050449
183 rdf:type schema:CreativeWork
184 sg:pub.10.1007/s12272-008-1118-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035050504
185 https://doi.org/10.1007/s12272-008-1118-5
186 rdf:type schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1078435952 schema:CreativeWork
188 https://doi.org/10.1016/j.annepidem.2005.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051745689
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.cbi.2009.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010652564
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.cep.2007.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000892019
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.ddmec.2006.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048464720
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.jchromb.2004.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051287478
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.jep.2005.04.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036003554
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.lfs.2005.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028754905
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.lfs.2007.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042386384
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.mam.2005.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038428456
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.phymed.2007.07.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032282354
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.phytochem.2007.04.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007525576
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s0024-3205(97)00741-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030802546
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0031-9422(98)00051-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000740871
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0140-6736(02)11030-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046319386
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1021/np50105a012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056236643
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/j.2042-7158.1987.tb03454.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032771233
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1111/j.2042-7158.1991.tb03461.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035473093
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1159/000007703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020567213
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1248/bpb.18.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013999153
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1515/znc-2007-7-812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067584142
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.412299.5 schema:alternateName Universidade do Vale do Itajaí
229 schema:name Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí, UNIVALI, Rua Uruguai, 458, 88302-202, Itajaí, Santa Catarina, Brazil
230 Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajaí, UNIVALI, Rua Uruguai, 458, 88302-202, Itajaí, Santa Catarina, Brazil
231 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...