SEA0400 fails to alter the magnitude of intracellular Ca2+ transients and contractions in Langendorff-perfused guinea pig heart View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-05-06

AUTHORS

Norbert Szentandrássy, Péter Birinyi, Gyula Szigeti, Attila Farkas, János Magyar, András Tóth, László Csernoch, András Varró, Péter P. Nánási

ABSTRACT

SEA0400 is a recently developed inhibitor of the Na+/Ca2+ exchanger (NCX) shown to suppress both forward and reverse mode operation of NCX. Present experiments were designed to study the effect of partial blockade of NCX on Ca handling and contractility in Langendorff-perfused guinea pig hearts loaded with the fluorescent Ca-sensitive dye fura-2. Left ventricular pressure and intracellular calcium concentration ([Ca2+]i) were synchronously recorded before and after cumulative superfusion with 0.3 and 1 μM SEA0400. SEA0400 caused no significant change in the systolic and diastolic values of left ventricular pressure and [Ca2+]i. Accordingly, pulse pressure and amplitude of the [Ca2+]i transient also remained unchanged in the presence of SEA0400. SEA0400 had no influence either on the time required to reach peak values of pressure and [Ca2+]i or on half relaxation time. On the other hand, both 0.3 and 1 μM SEA0400 significantly increased the decay time constant of [Ca2+]i transients, obtained by fitting its descending limb between 30% and 90% of relaxation, from 127 ± 7 to 165 ± 7 and 177 ± 14 ms, respectively (P < 0.05, n = 6). In contrast to the guinea pig hearts, rat hearts responded to SEA0400 treatment with increased [Ca2+]i transients and contractility. These interspecies differences observed in the effect of SEA0400 can be explained by the known differences in calcium handling between the two species. More... »

PAGES

65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00210-008-0296-5

DOI

http://dx.doi.org/10.1007/s00210-008-0296-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025471304

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18458877


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aniline Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fura-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guinea Pigs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenyl Ethers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium-Calcium Exchanger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szentandr\u00e1ssy", 
        "givenName": "Norbert", 
        "id": "sg:person.0741603700.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741603700.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Birinyi", 
        "givenName": "P\u00e9ter", 
        "id": "sg:person.0606370563.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606370563.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szigeti", 
        "givenName": "Gyula", 
        "id": "sg:person.01036343537.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036343537.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Pharmacotherapy, University of Szeged, P.O. Box 427, 6701, Szeged, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.9008.1", 
          "name": [
            "Department of Pharmacology and Pharmacotherapy, University of Szeged, P.O. Box 427, 6701, Szeged, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farkas", 
        "givenName": "Attila", 
        "id": "sg:person.01054340564.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054340564.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magyar", 
        "givenName": "J\u00e1nos", 
        "id": "sg:person.01206027354.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206027354.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Pharmacotherapy, University of Szeged, P.O. Box 427, 6701, Szeged, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.9008.1", 
          "name": [
            "Department of Pharmacology and Pharmacotherapy, University of Szeged, P.O. Box 427, 6701, Szeged, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "T\u00f3th", 
        "givenName": "Andr\u00e1s", 
        "id": "sg:person.015311001242.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015311001242.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Csernoch", 
        "givenName": "L\u00e1szl\u00f3", 
        "id": "sg:person.01205301115.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205301115.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Pharmacotherapy, University of Szeged, P.O. Box 427, 6701, Szeged, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.9008.1", 
          "name": [
            "Department of Pharmacology and Pharmacotherapy, University of Szeged, P.O. Box 427, 6701, Szeged, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varr\u00f3", 
        "givenName": "Andr\u00e1s", 
        "id": "sg:person.015203014040.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015203014040.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "N\u00e1n\u00e1si", 
        "givenName": "P\u00e9ter P.", 
        "id": "sg:person.0724365203.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724365203.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00210-005-1051-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049313328", 
          "https://doi.org/10.1007/s00210-005-1051-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-29715-4_6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036253717", 
          "https://doi.org/10.1007/3-540-29715-4_6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-010-0658-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008786655", 
          "https://doi.org/10.1007/978-94-010-0658-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-005-1079-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040834200", 
          "https://doi.org/10.1007/s00210-005-1079-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-05-06", 
    "datePublishedReg": "2008-05-06", 
    "description": "SEA0400 is a recently developed inhibitor of the Na+/Ca2+ exchanger (NCX) shown to suppress both forward and reverse mode operation of NCX. Present experiments were designed to study the effect of partial blockade of NCX on Ca handling and contractility in Langendorff-perfused guinea pig hearts loaded with the fluorescent Ca-sensitive dye fura-2. Left ventricular pressure and intracellular calcium concentration ([Ca2+]i) were synchronously recorded before and after cumulative superfusion with 0.3 and 1\u00a0\u03bcM SEA0400. SEA0400 caused no significant change in the systolic and diastolic values of left ventricular pressure and [Ca2+]i. Accordingly, pulse pressure and amplitude of the [Ca2+]i transient also remained unchanged in the presence of SEA0400. SEA0400 had no influence either on the time required to reach peak values of pressure and [Ca2+]i or on half relaxation time. On the other hand, both 0.3 and 1\u00a0\u03bcM SEA0400 significantly increased the decay time constant of [Ca2+]i transients, obtained by fitting its descending limb between 30% and 90% of relaxation, from 127\u2009\u00b1\u20097 to 165\u2009\u00b1\u20097 and 177\u2009\u00b1\u200914\u00a0ms, respectively (P\u2009<\u20090.05, n\u2009=\u20096). In contrast to the guinea pig hearts, rat hearts responded to SEA0400 treatment with increased [Ca2+]i transients and contractility. These interspecies differences observed in the effect of SEA0400 can be explained by the known differences in calcium handling between the two species.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00210-008-0296-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4193655", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1015404", 
        "issn": [
          "0028-1298", 
          "1432-1912"
        ], 
        "name": "Naunyn-Schmiedeberg's Archives of Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "378"
      }
    ], 
    "keywords": [
      "guinea pig hearts", 
      "left ventricular pressure", 
      "ventricular pressure", 
      "pig hearts", 
      "intracellular calcium concentration", 
      "half-relaxation time", 
      "dye fura-2", 
      "pulse pressure", 
      "fura-2", 
      "calcium handling", 
      "SEA0400", 
      "diastolic values", 
      "partial blockade", 
      "Ca handling", 
      "rat heart", 
      "intracellular Ca2", 
      "calcium concentration", 
      "heart", 
      "contractility", 
      "Langendorff", 
      "NCX", 
      "significant changes", 
      "interspecies differences", 
      "present experiments", 
      "systolic", 
      "superfusion", 
      "blockade", 
      "limb", 
      "treatment", 
      "differences", 
      "pressure", 
      "inhibitors", 
      "contraction", 
      "Ca2", 
      "effect", 
      "time", 
      "ms", 
      "peak value", 
      "contrast", 
      "handling", 
      "\u03bcM", 
      "presence", 
      "concentration", 
      "changes", 
      "transients", 
      "values", 
      "hand", 
      "amplitude", 
      "relaxation", 
      "influence", 
      "magnitude", 
      "operation", 
      "species", 
      "relaxation time", 
      "experiments", 
      "exchanger", 
      "decay time", 
      "mode operation", 
      "fluorescent Ca-sensitive dye fura-2", 
      "Ca-sensitive dye fura-2", 
      "cumulative superfusion", 
      "presence of SEA0400", 
      "\u03bcM SEA0400", 
      "SEA0400 treatment"
    ], 
    "name": "SEA0400 fails to alter the magnitude of intracellular Ca2+ transients and contractions in Langendorff-perfused guinea pig heart", 
    "pagination": "65", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025471304"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00210-008-0296-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18458877"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00210-008-0296-5", 
      "https://app.dimensions.ai/details/publication/pub.1025471304"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_476.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00210-008-0296-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00210-008-0296-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00210-008-0296-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00210-008-0296-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00210-008-0296-5'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      22 PREDICATES      108 URIs      96 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00210-008-0296-5 schema:about N16d415b670484579bbcb38b99da6a12c
2 N1b92ddaf9f1a404e98f07c8dea94c265
3 N2b1d6eadad5d4830816f581af2b96ae5
4 N358aa75df7cc4e04886ce5ec1e1777d8
5 N4e40730f1aa8463eb5b6c9fcfa81b6a6
6 N7d12e52dea124a4db43c34ebdae47afb
7 N8329b576b2fb4bd6a61bcad09a4ba401
8 N97c1b97172b64460a1fe78e65f5da54b
9 N9b2d61ad86e94bdba9f5a9b9f92d31b5
10 Na8e7c023936f4aeeb8ba111b287deb5a
11 Nb9495cb184f74c6ebca29b2c08f72945
12 Nd47786db29384e89ae4d49123bf5c80d
13 Ndadf9bc222ee4cd2a2cc1e16009b0fae
14 Nf040e0f4e4c345568c82b8e6a4ec2e5a
15 anzsrc-for:11
16 anzsrc-for:1116
17 schema:author N3d5ed241900f4241bed88c33d5a0070d
18 schema:citation sg:pub.10.1007/3-540-29715-4_6
19 sg:pub.10.1007/978-94-010-0658-3
20 sg:pub.10.1007/s00210-005-1051-9
21 sg:pub.10.1007/s00210-005-1079-x
22 schema:datePublished 2008-05-06
23 schema:datePublishedReg 2008-05-06
24 schema:description SEA0400 is a recently developed inhibitor of the Na+/Ca2+ exchanger (NCX) shown to suppress both forward and reverse mode operation of NCX. Present experiments were designed to study the effect of partial blockade of NCX on Ca handling and contractility in Langendorff-perfused guinea pig hearts loaded with the fluorescent Ca-sensitive dye fura-2. Left ventricular pressure and intracellular calcium concentration ([Ca2+]i) were synchronously recorded before and after cumulative superfusion with 0.3 and 1 μM SEA0400. SEA0400 caused no significant change in the systolic and diastolic values of left ventricular pressure and [Ca2+]i. Accordingly, pulse pressure and amplitude of the [Ca2+]i transient also remained unchanged in the presence of SEA0400. SEA0400 had no influence either on the time required to reach peak values of pressure and [Ca2+]i or on half relaxation time. On the other hand, both 0.3 and 1 μM SEA0400 significantly increased the decay time constant of [Ca2+]i transients, obtained by fitting its descending limb between 30% and 90% of relaxation, from 127 ± 7 to 165 ± 7 and 177 ± 14 ms, respectively (P < 0.05, n = 6). In contrast to the guinea pig hearts, rat hearts responded to SEA0400 treatment with increased [Ca2+]i transients and contractility. These interspecies differences observed in the effect of SEA0400 can be explained by the known differences in calcium handling between the two species.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N873cb24752614301b731ef1b917efbc7
29 Nf4de382a856040b1983b88923309718c
30 sg:journal.1015404
31 schema:keywords Ca handling
32 Ca-sensitive dye fura-2
33 Ca2
34 Langendorff
35 NCX
36 SEA0400
37 SEA0400 treatment
38 amplitude
39 blockade
40 calcium concentration
41 calcium handling
42 changes
43 concentration
44 contractility
45 contraction
46 contrast
47 cumulative superfusion
48 decay time
49 diastolic values
50 differences
51 dye fura-2
52 effect
53 exchanger
54 experiments
55 fluorescent Ca-sensitive dye fura-2
56 fura-2
57 guinea pig hearts
58 half-relaxation time
59 hand
60 handling
61 heart
62 influence
63 inhibitors
64 interspecies differences
65 intracellular Ca2
66 intracellular calcium concentration
67 left ventricular pressure
68 limb
69 magnitude
70 mode operation
71 ms
72 operation
73 partial blockade
74 peak value
75 pig hearts
76 presence
77 presence of SEA0400
78 present experiments
79 pressure
80 pulse pressure
81 rat heart
82 relaxation
83 relaxation time
84 significant changes
85 species
86 superfusion
87 systolic
88 time
89 transients
90 treatment
91 values
92 ventricular pressure
93 μM
94 μM SEA0400
95 schema:name SEA0400 fails to alter the magnitude of intracellular Ca2+ transients and contractions in Langendorff-perfused guinea pig heart
96 schema:pagination 65
97 schema:productId Nab434547623844c2bb417175c47e377d
98 Nb3f0e916690948baa38c2e95f594669e
99 Ncd7e12bb683c443ba90363321ff38ecf
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025471304
101 https://doi.org/10.1007/s00210-008-0296-5
102 schema:sdDatePublished 2022-01-01T18:19
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N47f60eaad26c4c96bc23d4e907dc4ada
105 schema:url https://doi.org/10.1007/s00210-008-0296-5
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N11a81c97176248049522f23cb42ae12f rdf:first sg:person.01205301115.74
110 rdf:rest N923d06ec1b1b40ddadc8d619efe11f17
111 N16d415b670484579bbcb38b99da6a12c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Rats
113 rdf:type schema:DefinedTerm
114 N1b92ddaf9f1a404e98f07c8dea94c265 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Dose-Response Relationship, Drug
116 rdf:type schema:DefinedTerm
117 N2b1d6eadad5d4830816f581af2b96ae5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Species Specificity
119 rdf:type schema:DefinedTerm
120 N2cdc487051d4457f9aae33105300076f rdf:first sg:person.01206027354.83
121 rdf:rest N99912e766b8249b58e650e68850bd30f
122 N358aa75df7cc4e04886ce5ec1e1777d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Heart
124 rdf:type schema:DefinedTerm
125 N3d5ed241900f4241bed88c33d5a0070d rdf:first sg:person.0741603700.70
126 rdf:rest N5ee36b10b13949169769e49d023fd368
127 N47f60eaad26c4c96bc23d4e907dc4ada schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N4e40730f1aa8463eb5b6c9fcfa81b6a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Myocardial Contraction
131 rdf:type schema:DefinedTerm
132 N5ee36b10b13949169769e49d023fd368 rdf:first sg:person.0606370563.77
133 rdf:rest Nf6ae7515b8b546708d6217000813ab01
134 N7d12e52dea124a4db43c34ebdae47afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Time Factors
136 rdf:type schema:DefinedTerm
137 N8329b576b2fb4bd6a61bcad09a4ba401 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Animals
139 rdf:type schema:DefinedTerm
140 N873cb24752614301b731ef1b917efbc7 schema:issueNumber 1
141 rdf:type schema:PublicationIssue
142 N923d06ec1b1b40ddadc8d619efe11f17 rdf:first sg:person.015203014040.44
143 rdf:rest Na5c1a1e569da4ca0946fa75ba1ca7de5
144 N97c1b97172b64460a1fe78e65f5da54b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Sodium-Calcium Exchanger
146 rdf:type schema:DefinedTerm
147 N99912e766b8249b58e650e68850bd30f rdf:first sg:person.015311001242.33
148 rdf:rest N11a81c97176248049522f23cb42ae12f
149 N9b2d61ad86e94bdba9f5a9b9f92d31b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Phenyl Ethers
151 rdf:type schema:DefinedTerm
152 N9d8fe658cce94f4b81771413775fe32c rdf:first sg:person.01054340564.59
153 rdf:rest N2cdc487051d4457f9aae33105300076f
154 Na5c1a1e569da4ca0946fa75ba1ca7de5 rdf:first sg:person.0724365203.35
155 rdf:rest rdf:nil
156 Na8e7c023936f4aeeb8ba111b287deb5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Fura-2
158 rdf:type schema:DefinedTerm
159 Nab434547623844c2bb417175c47e377d schema:name doi
160 schema:value 10.1007/s00210-008-0296-5
161 rdf:type schema:PropertyValue
162 Nb3f0e916690948baa38c2e95f594669e schema:name pubmed_id
163 schema:value 18458877
164 rdf:type schema:PropertyValue
165 Nb9495cb184f74c6ebca29b2c08f72945 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Calcium
167 rdf:type schema:DefinedTerm
168 Ncd7e12bb683c443ba90363321ff38ecf schema:name dimensions_id
169 schema:value pub.1025471304
170 rdf:type schema:PropertyValue
171 Nd47786db29384e89ae4d49123bf5c80d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Aniline Compounds
173 rdf:type schema:DefinedTerm
174 Ndadf9bc222ee4cd2a2cc1e16009b0fae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Guinea Pigs
176 rdf:type schema:DefinedTerm
177 Nf040e0f4e4c345568c82b8e6a4ec2e5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Blood Pressure
179 rdf:type schema:DefinedTerm
180 Nf4de382a856040b1983b88923309718c schema:volumeNumber 378
181 rdf:type schema:PublicationVolume
182 Nf6ae7515b8b546708d6217000813ab01 rdf:first sg:person.01036343537.32
183 rdf:rest N9d8fe658cce94f4b81771413775fe32c
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical Physiology
189 rdf:type schema:DefinedTerm
190 sg:grant.4193655 http://pending.schema.org/fundedItem sg:pub.10.1007/s00210-008-0296-5
191 rdf:type schema:MonetaryGrant
192 sg:journal.1015404 schema:issn 0028-1298
193 1432-1912
194 schema:name Naunyn-Schmiedeberg's Archives of Pharmacology
195 schema:publisher Springer Nature
196 rdf:type schema:Periodical
197 sg:person.01036343537.32 schema:affiliation grid-institutes:grid.7122.6
198 schema:familyName Szigeti
199 schema:givenName Gyula
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036343537.32
201 rdf:type schema:Person
202 sg:person.01054340564.59 schema:affiliation grid-institutes:grid.9008.1
203 schema:familyName Farkas
204 schema:givenName Attila
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054340564.59
206 rdf:type schema:Person
207 sg:person.01205301115.74 schema:affiliation grid-institutes:grid.7122.6
208 schema:familyName Csernoch
209 schema:givenName László
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205301115.74
211 rdf:type schema:Person
212 sg:person.01206027354.83 schema:affiliation grid-institutes:grid.7122.6
213 schema:familyName Magyar
214 schema:givenName János
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206027354.83
216 rdf:type schema:Person
217 sg:person.015203014040.44 schema:affiliation grid-institutes:grid.9008.1
218 schema:familyName Varró
219 schema:givenName András
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015203014040.44
221 rdf:type schema:Person
222 sg:person.015311001242.33 schema:affiliation grid-institutes:grid.9008.1
223 schema:familyName Tóth
224 schema:givenName András
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015311001242.33
226 rdf:type schema:Person
227 sg:person.0606370563.77 schema:affiliation grid-institutes:grid.7122.6
228 schema:familyName Birinyi
229 schema:givenName Péter
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606370563.77
231 rdf:type schema:Person
232 sg:person.0724365203.35 schema:affiliation grid-institutes:grid.7122.6
233 schema:familyName Nánási
234 schema:givenName Péter P.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724365203.35
236 rdf:type schema:Person
237 sg:person.0741603700.70 schema:affiliation grid-institutes:grid.7122.6
238 schema:familyName Szentandrássy
239 schema:givenName Norbert
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741603700.70
241 rdf:type schema:Person
242 sg:pub.10.1007/3-540-29715-4_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036253717
243 https://doi.org/10.1007/3-540-29715-4_6
244 rdf:type schema:CreativeWork
245 sg:pub.10.1007/978-94-010-0658-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008786655
246 https://doi.org/10.1007/978-94-010-0658-3
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s00210-005-1051-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049313328
249 https://doi.org/10.1007/s00210-005-1051-9
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s00210-005-1079-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040834200
252 https://doi.org/10.1007/s00210-005-1079-x
253 rdf:type schema:CreativeWork
254 grid-institutes:grid.7122.6 schema:alternateName Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary
255 schema:name Department of Physiology, University of Debrecen, P.O. Box 22, 4012, Debrecen, Hungary
256 rdf:type schema:Organization
257 grid-institutes:grid.9008.1 schema:alternateName Department of Pharmacology and Pharmacotherapy, University of Szeged, P.O. Box 427, 6701, Szeged, Hungary
258 schema:name Department of Pharmacology and Pharmacotherapy, University of Szeged, P.O. Box 427, 6701, Szeged, Hungary
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...