Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-04-17

AUTHORS

Parviz Afiatpour, Jamshid Latifpour, Wataru Takahashi, Makoto Yono, Harris E. Foster, Kazuyoshi Ikeda, Mehdi Pouresmail, Robert M. Weiss

ABSTRACT

The effect of aging on functional, biochemical, anatomical and molecular properties of endothelin (ET) receptors in bladder smooth muscle of the 3-week-, 3-month- and 22-month-old rats was examined using isolated muscle bath techniques, radioligand binding on membrane particulates and slide mounted tissue sections, and real-time reverse transcription polymerase chain reaction (RT-PCR). ET-1 induced significantly larger contractile responses in bladder dome muscle strips from 3-week- than from 3-month- and 22-month-old rats. The expression level of total ET receptors, determined by saturation binding experiments with [125I]ET-1, was higher in detrusor from 3-week- than 22-month-old rats. Inhibition studies with BQ123, a selective ETA receptor antagonist, indicated the predominance of the ETA receptor subtype and a similar proportion of ETA to ETB receptor subtypes in the rat detrusor at all ages studied. Autoradiographic data support the age-dependent decrease in the density of ET receptors and also indicate that the ETA receptor subtype is primarily located in the smooth muscle layer, whereas the ETB receptor subtype is located in both the urothelial and smooth muscle layers. Determined by real-time RT-PCR, ET 1, ET-3, ECE-1 and ET receptor subtype (ETA and ETB) mRNAs were shown to be higher in bladders of 3-week- compared to 3-month- or 22-month-old rats. This study indicates age-dependent alterations in the ET receptor system at both gene transcript and protein levels in the Fischer rat detrusor. More... »

PAGES

462-472

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00210-003-0715-6

DOI

http://dx.doi.org/10.1007/s00210-003-0715-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011773390

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12700883


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63 decrease
64 density
65 detrusor
66 developmental changes
67 effect
68 endothelin receptors
69 eta
70 experiments
71 expression levels
72 gene transcripts
73 inhibition studies
74 larger contractile responses
75 layer
76 levels
77 mRNA
78 membrane particulates
79 molecular properties
80 muscle
81 muscle bath technique
82 muscle layer
83 muscle strips
84 particulates
85 polymerase chain reaction
86 predominance
87 properties
88 proportion
89 protein levels
90 rat detrusor
91 rats
92 reaction
93 real-time RT-PCR
94 real-time reverse transcription-polymerase chain reaction
95 receptor antagonist
96 receptor subtype mRNAs
97 receptor subtypes
98 receptor system
99 receptors
100 response
101 reverse transcription-polymerase chain reaction
102 saturation
103 sections
104 selective ETA receptor antagonist
105 similar proportions
106 slides
107 smooth muscle
108 smooth muscle layer
109 strips
110 study
111 subtype mRNAs
112 subtypes
113 system
114 technique
115 tissue sections
116 total ET receptors
117 transcription-polymerase chain reaction
118 transcripts
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