The response of hepatocytes isolated from phenobarbitone treated mice to mitogenic growth factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-05

AUTHORS

Karin Fletcher, Terry C. Orton, J. Kevin Chipman, Alastair J. Strain

ABSTRACT

The ability was investigated of epidermal growth factor (EGF) and hepatocyte growth factor (HGF) to stimulate DNA synthesis in hepatocytes isolated from C57Bl/6J mice following 1, 3, 7, 30 and 90 days pre-treatment with the hepatomegalic drug, phenobarbitone (PB). A 3-fold increase in S-phase labelled hepatocytes was observed in the absence of growth factors after 3 days treatment with PB, which was not seen at other investigated time points. This suggests that the proliferative influence present in vivo at this time interval is maintained in the ex vivo model. Maximum labelling indices of >5-fold the unstimulated control value were observed in hepatocytes isolated from control and 1 day PB pre-treated mice when cultured in the presence of 5 or 10 ng/ml EGF or HGF. Hepatocytes isolated from 3, 7, 30 or 90 day treated mice showed a considerably reduced responsiveness to growth factors; maximum labelling indices did not exceed by a factor of 2 the value obtained in the absence of growth factors. However, the apparent decrease in responsiveness to growth factors in hepatocytes isolated from 3 day pre-treated mice was due to an increased background level of proliferation and the attainment of a `ceiling level' of DNA synthesis at approx. 35%. DNA synthesis was not further enhanced by addition of both EGF and HGF. This maximal level of stimulation may indicate that only a specific hepatocyte sub-population is capable of responding to growth factors under the conditions employed. The loss in sensitivity to mitogenic stimuli after 7 days PB pre-treatment correlates with a reported decrease in receptor protein and mRNA levels in rats and coincides with the in vivo shift from hyperplasia to hypertrophy. More... »

PAGES

422-428

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002040050406

DOI

http://dx.doi.org/10.1007/s002040050406

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018383259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9209687


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Separation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Replication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Synergism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocyte Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperplasia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenobarbital", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, GB", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, GB"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fletcher", 
        "givenName": "Karin", 
        "id": "sg:person.0701626175.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701626175.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield , SK10 4TG, UK, GB", 
          "id": "http://www.grid.ac/institutes/grid.417815.e", 
          "name": [
            "Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield , SK10 4TG, UK, GB"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orton", 
        "givenName": "Terry C.", 
        "id": "sg:person.01005713060.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005713060.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, GB", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, GB"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chipman", 
        "givenName": "J. Kevin", 
        "id": "sg:person.01072542354.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072542354.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, GB", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, GB"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strain", 
        "givenName": "Alastair J.", 
        "id": "sg:person.0631732143.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631732143.23"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1997-05", 
    "datePublishedReg": "1997-05-01", 
    "description": "Abstract The ability was investigated of epidermal growth factor (EGF) and hepatocyte growth factor (HGF) to stimulate DNA synthesis in hepatocytes isolated from C57Bl/6J mice following 1, 3, 7, 30 and 90 days pre-treatment with the hepatomegalic drug, phenobarbitone (PB). A 3-fold increase in S-phase labelled hepatocytes was observed in the absence of growth factors after 3 days treatment with PB, which was not seen at other investigated time points. This suggests that the proliferative influence present in vivo at this time interval is maintained in the ex vivo model. Maximum labelling indices of >5-fold the unstimulated control value were observed in hepatocytes isolated from control and 1 day PB pre-treated mice when cultured in the presence of 5 or 10\u2009ng/ml EGF or HGF. Hepatocytes isolated from 3, 7, 30 or 90 day treated mice showed a considerably reduced responsiveness to growth factors; maximum labelling indices did not exceed by a factor of 2 the value obtained in the absence of growth factors. However, the apparent decrease in responsiveness to growth factors in hepatocytes isolated from 3 day pre-treated mice was due to an increased background level of proliferation and the attainment of a `ceiling level' of DNA synthesis at approx. 35%. DNA synthesis was not further enhanced by addition of both EGF and HGF. This maximal level of stimulation may indicate that only a specific hepatocyte sub-population is capable of responding to growth factors under the conditions employed. The loss in sensitivity to mitogenic stimuli after 7 days PB pre-treatment correlates with a reported decrease in receptor protein and mRNA levels in rats and coincides with the in vivo shift from hyperplasia to hypertrophy.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s002040050406", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019669", 
        "issn": [
          "0340-5761", 
          "1432-0738"
        ], 
        "name": "Archives of Toxicology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "71"
      }
    ], 
    "keywords": [
      "pre-treated mice", 
      "hepatocyte growth factor", 
      "epidermal growth factor", 
      "maximum labeling index", 
      "growth factor", 
      "labeling index", 
      "unstimulated control value", 
      "ex vivo model", 
      "DNA synthesis", 
      "vivo shift", 
      "C57BL/6J mice", 
      "response of hepatocytes", 
      "days treatment", 
      "vivo model", 
      "control values", 
      "mice", 
      "proliferative influence", 
      "time points", 
      "phenobarbitone", 
      "mRNA levels", 
      "specific hepatocytes", 
      "maximal levels", 
      "hepatocytes", 
      "receptor protein", 
      "responsiveness", 
      "days", 
      "apparent decrease", 
      "factors", 
      "levels", 
      "hyperplasia", 
      "hypertrophy", 
      "rats", 
      "stimulation", 
      "time interval", 
      "drugs", 
      "index", 
      "absence", 
      "decrease", 
      "treatment", 
      "proliferation", 
      "vivo", 
      "ceiling level", 
      "correlates", 
      "stimuli", 
      "response", 
      "intervals", 
      "background levels", 
      "control", 
      "increase", 
      "sensitivity", 
      "protein", 
      "loss", 
      "presence", 
      "ability", 
      "increased background level", 
      "addition", 
      "values", 
      "attainment", 
      "synthesis", 
      "approx", 
      "Abstract", 
      "conditions", 
      "influence", 
      "point", 
      "model", 
      "phase", 
      "shift", 
      "coincide", 
      "hepatomegalic drug", 
      "day PB pre-treated mice", 
      "PB pre-treated mice", 
      "day pre-treated mice", 
      "days PB pre-treatment correlates", 
      "PB pre-treatment correlates", 
      "pre-treatment correlates"
    ], 
    "name": "The response of hepatocytes isolated from phenobarbitone treated mice to mitogenic growth factors", 
    "pagination": "422-428", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018383259"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002040050406"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9209687"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002040050406", 
      "https://app.dimensions.ai/details/publication/pub.1018383259"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_284.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s002040050406"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002040050406'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002040050406'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002040050406'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002040050406'


 

This table displays all metadata directly associated to this object as RDF triples.

225 TRIPLES      21 PREDICATES      118 URIs      110 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002040050406 schema:about N0ecd1cb3d2f44a05895b372f92b4aeb3
2 N21079d94a6a742b09c4cad15ae8bcac1
3 N2f3c610db429429585d8f9dcb852b7a5
4 N59279009bec4494bacfb5944b44ec8b0
5 N6315e72678ba4b3d8c5fe9ffa45107be
6 N70d728547edd41c5b04129607363ef39
7 N72b708898b5e44d9b4f933c15299a61a
8 N7fa178b1fae44c9cabd3062ba9332c1d
9 N96498ae1372a4c15b96cc41c2d946a3b
10 N9687474fa6cb4a1badb9332fb750be99
11 Na24c93c653a944338bb2bd0fa9e0e533
12 Na49107e79e4842df9b26e6d28c7ef31c
13 Nb7f46b3327ed4c218186be36acc40a29
14 Nd7f8e90ac54141d98125ab995e9f193b
15 Nef57127c18954fa7bbc3e47b59bb528f
16 Nfd5fc2100a7145eabd6fa6bcbbf860c6
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N674bf64d664c4da2af825a3bc590f865
20 schema:datePublished 1997-05
21 schema:datePublishedReg 1997-05-01
22 schema:description Abstract The ability was investigated of epidermal growth factor (EGF) and hepatocyte growth factor (HGF) to stimulate DNA synthesis in hepatocytes isolated from C57Bl/6J mice following 1, 3, 7, 30 and 90 days pre-treatment with the hepatomegalic drug, phenobarbitone (PB). A 3-fold increase in S-phase labelled hepatocytes was observed in the absence of growth factors after 3 days treatment with PB, which was not seen at other investigated time points. This suggests that the proliferative influence present in vivo at this time interval is maintained in the ex vivo model. Maximum labelling indices of >5-fold the unstimulated control value were observed in hepatocytes isolated from control and 1 day PB pre-treated mice when cultured in the presence of 5 or 10‚ÄČng/ml EGF or HGF. Hepatocytes isolated from 3, 7, 30 or 90 day treated mice showed a considerably reduced responsiveness to growth factors; maximum labelling indices did not exceed by a factor of 2 the value obtained in the absence of growth factors. However, the apparent decrease in responsiveness to growth factors in hepatocytes isolated from 3 day pre-treated mice was due to an increased background level of proliferation and the attainment of a `ceiling level' of DNA synthesis at approx. 35%. DNA synthesis was not further enhanced by addition of both EGF and HGF. This maximal level of stimulation may indicate that only a specific hepatocyte sub-population is capable of responding to growth factors under the conditions employed. The loss in sensitivity to mitogenic stimuli after 7 days PB pre-treatment correlates with a reported decrease in receptor protein and mRNA levels in rats and coincides with the in vivo shift from hyperplasia to hypertrophy.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf N3b881b6299c0419c91d719134b536aa0
27 N6c21fc690f3b453cb7e2cc5a282bf0a3
28 sg:journal.1019669
29 schema:keywords Abstract
30 C57BL/6J mice
31 DNA synthesis
32 PB pre-treated mice
33 PB pre-treatment correlates
34 ability
35 absence
36 addition
37 apparent decrease
38 approx
39 attainment
40 background levels
41 ceiling level
42 coincide
43 conditions
44 control
45 control values
46 correlates
47 day PB pre-treated mice
48 day pre-treated mice
49 days
50 days PB pre-treatment correlates
51 days treatment
52 decrease
53 drugs
54 epidermal growth factor
55 ex vivo model
56 factors
57 growth factor
58 hepatocyte growth factor
59 hepatocytes
60 hepatomegalic drug
61 hyperplasia
62 hypertrophy
63 increase
64 increased background level
65 index
66 influence
67 intervals
68 labeling index
69 levels
70 loss
71 mRNA levels
72 maximal levels
73 maximum labeling index
74 mice
75 model
76 phase
77 phenobarbitone
78 point
79 pre-treated mice
80 pre-treatment correlates
81 presence
82 proliferation
83 proliferative influence
84 protein
85 rats
86 receptor protein
87 response
88 response of hepatocytes
89 responsiveness
90 sensitivity
91 shift
92 specific hepatocytes
93 stimulation
94 stimuli
95 synthesis
96 time interval
97 time points
98 treatment
99 unstimulated control value
100 values
101 vivo
102 vivo model
103 vivo shift
104 schema:name The response of hepatocytes isolated from phenobarbitone treated mice to mitogenic growth factors
105 schema:pagination 422-428
106 schema:productId Na000af8d158346cbb3adb4753b0a80f3
107 Nf105dc50f44c4a1bb1e0bc971c4885a1
108 Nf672587243a2413880fb3289207c2641
109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018383259
110 https://doi.org/10.1007/s002040050406
111 schema:sdDatePublished 2022-01-01T18:08
112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
113 schema:sdPublisher Naf9d3dd3772d46129fd65b4994cfcdd0
114 schema:url https://doi.org/10.1007/s002040050406
115 sgo:license sg:explorer/license/
116 sgo:sdDataset articles
117 rdf:type schema:ScholarlyArticle
118 N0ecd1cb3d2f44a05895b372f92b4aeb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Drug Synergism
120 rdf:type schema:DefinedTerm
121 N21079d94a6a742b09c4cad15ae8bcac1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Hyperplasia
123 rdf:type schema:DefinedTerm
124 N2f3c610db429429585d8f9dcb852b7a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Hepatocyte Growth Factor
126 rdf:type schema:DefinedTerm
127 N3b881b6299c0419c91d719134b536aa0 schema:volumeNumber 71
128 rdf:type schema:PublicationVolume
129 N5899413b8a1e405fa97ac238be82edb2 rdf:first sg:person.0631732143.23
130 rdf:rest rdf:nil
131 N59279009bec4494bacfb5944b44ec8b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cells, Cultured
133 rdf:type schema:DefinedTerm
134 N6315e72678ba4b3d8c5fe9ffa45107be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Epidermal Growth Factor
136 rdf:type schema:DefinedTerm
137 N674bf64d664c4da2af825a3bc590f865 rdf:first sg:person.0701626175.51
138 rdf:rest Ne652f5cfcc9744659ce9e1b35ee62d3c
139 N6c21fc690f3b453cb7e2cc5a282bf0a3 schema:issueNumber 7
140 rdf:type schema:PublicationIssue
141 N70d728547edd41c5b04129607363ef39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Separation
143 rdf:type schema:DefinedTerm
144 N72b708898b5e44d9b4f933c15299a61a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Liver
146 rdf:type schema:DefinedTerm
147 N7fa178b1fae44c9cabd3062ba9332c1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Mice
149 rdf:type schema:DefinedTerm
150 N921c4c4c4642487a97a01f9407c8962d rdf:first sg:person.01072542354.75
151 rdf:rest N5899413b8a1e405fa97ac238be82edb2
152 N96498ae1372a4c15b96cc41c2d946a3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Growth Substances
154 rdf:type schema:DefinedTerm
155 N9687474fa6cb4a1badb9332fb750be99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Male
157 rdf:type schema:DefinedTerm
158 Na000af8d158346cbb3adb4753b0a80f3 schema:name doi
159 schema:value 10.1007/s002040050406
160 rdf:type schema:PropertyValue
161 Na24c93c653a944338bb2bd0fa9e0e533 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name DNA Replication
163 rdf:type schema:DefinedTerm
164 Na49107e79e4842df9b26e6d28c7ef31c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Animals
166 rdf:type schema:DefinedTerm
167 Naf9d3dd3772d46129fd65b4994cfcdd0 schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 Nb7f46b3327ed4c218186be36acc40a29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Time Factors
171 rdf:type schema:DefinedTerm
172 Nd7f8e90ac54141d98125ab995e9f193b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Phenobarbital
174 rdf:type schema:DefinedTerm
175 Ne652f5cfcc9744659ce9e1b35ee62d3c rdf:first sg:person.01005713060.27
176 rdf:rest N921c4c4c4642487a97a01f9407c8962d
177 Nef57127c18954fa7bbc3e47b59bb528f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Cell Division
179 rdf:type schema:DefinedTerm
180 Nf105dc50f44c4a1bb1e0bc971c4885a1 schema:name pubmed_id
181 schema:value 9209687
182 rdf:type schema:PropertyValue
183 Nf672587243a2413880fb3289207c2641 schema:name dimensions_id
184 schema:value pub.1018383259
185 rdf:type schema:PropertyValue
186 Nfd5fc2100a7145eabd6fa6bcbbf860c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Mice, Inbred C57BL
188 rdf:type schema:DefinedTerm
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
193 schema:name Clinical Sciences
194 rdf:type schema:DefinedTerm
195 sg:journal.1019669 schema:issn 0340-5761
196 1432-0738
197 schema:name Archives of Toxicology
198 schema:publisher Springer Nature
199 rdf:type schema:Periodical
200 sg:person.01005713060.27 schema:affiliation grid-institutes:grid.417815.e
201 schema:familyName Orton
202 schema:givenName Terry C.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005713060.27
204 rdf:type schema:Person
205 sg:person.01072542354.75 schema:affiliation grid-institutes:grid.6572.6
206 schema:familyName Chipman
207 schema:givenName J. Kevin
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072542354.75
209 rdf:type schema:Person
210 sg:person.0631732143.23 schema:affiliation grid-institutes:grid.6572.6
211 schema:familyName Strain
212 schema:givenName Alastair J.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631732143.23
214 rdf:type schema:Person
215 sg:person.0701626175.51 schema:affiliation grid-institutes:grid.6572.6
216 schema:familyName Fletcher
217 schema:givenName Karin
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701626175.51
219 rdf:type schema:Person
220 grid-institutes:grid.417815.e schema:alternateName Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield , SK10 4TG, UK, GB
221 schema:name Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield , SK10 4TG, UK, GB
222 rdf:type schema:Organization
223 grid-institutes:grid.6572.6 schema:alternateName School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, GB
224 schema:name School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, GB
225 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...