Quo vadis blood protein adductomics? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-11-13

AUTHORS

Gabriele Sabbioni, Billy W. Day

ABSTRACT

Chemicals are measured regularly in air, food, the environment, and the workplace. Biomonitoring of chemicals in biological fluids is a tool to determine the individual exposure. Blood protein adducts of xenobiotics are a marker of both exposure and the biologically effective dose. Urinary metabolites and blood metabolites are short term exposure markers. Stable hemoglobin adducts are exposure markers of up to 120 days. Blood protein adducts are formed with many xenobiotics at different sites of the blood proteins. Newer methods apply the techniques developed in the field of proteomics. Larger adducted peptides with 20 amino acids are used for quantitation. Unfortunately, at present the methods do not reach the limits of detection obtained with the methods looking at single amino acid adducts or at chemically cleaved adducts. Therefore, to progress in the field new approaches are needed. More... »

PAGES

79-103

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00204-021-03165-2

    DOI

    http://dx.doi.org/10.1007/s00204-021-03165-2

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34773488


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    41 schema:description Chemicals are measured regularly in air, food, the environment, and the workplace. Biomonitoring of chemicals in biological fluids is a tool to determine the individual exposure. Blood protein adducts of xenobiotics are a marker of both exposure and the biologically effective dose. Urinary metabolites and blood metabolites are short term exposure markers. Stable hemoglobin adducts are exposure markers of up to 120 days. Blood protein adducts are formed with many xenobiotics at different sites of the blood proteins. Newer methods apply the techniques developed in the field of proteomics. Larger adducted peptides with 20 amino acids are used for quantitation. Unfortunately, at present the methods do not reach the limits of detection obtained with the methods looking at single amino acid adducts or at chemically cleaved adducts. Therefore, to progress in the field new approaches are needed.
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    49 acid
    50 acid adducts
    51 adductomics
    52 adducts
    53 air
    54 amino acid adducts
    55 amino acids
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    58 biomonitoring
    59 blood metabolites
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    66 dose
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    75 hemoglobin adducts
    76 individual exposure
    77 limit
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    79 markers
    80 metabolites
    81 method
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    83 new method
    84 peptides
    85 protein
    86 protein adductomics
    87 protein adducts
    88 proteomics
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    97 schema:name Quo vadis blood protein adductomics?
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