Clioquinol inhibits dopamine-β-hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neuroblastoma ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-10-09

AUTHORS

Masato Katsuyama, En Kimura, Masakazu Ibi, Kazumi Iwata, Misaki Matsumoto, Nozomi Asaoka, Chihiro Yabe-Nishimura

ABSTRACT

Clioquinol (5-chloro-7-indo-8-quinolinol), a chelator and ionophore of copper/zinc, was extensively used as an amebicide to treat indigestion and diarrhea in the mid-1900s. However, it was withdrawn from the market in Japan because its use was epidemiologically linked to an increase in the incidence of subacute myelo-optic neuropathy (SMON). SMON is characterized by the subacute onset of sensory and motor disturbances in the lower extremities with occasional visual impairments, which are preceded by abdominal symptoms. Although pathological studies demonstrated axonopathy of the spinal cord and optic nerves, the underlying mechanisms of clioquinol toxicity have not been elucidated in detail. In the present study, a reporter assay revealed that clioquinol (20–50 µM) activated metal response element-dependent transcription in human neuroblastoma SH-SY5Y cells. Clioquinol significantly increased the cellular level of zinc within 1 h, suggesting zinc influx due to its ionophore effects. On the other hand, clioquinol (20–50 µM) significantly increased the cellular level of copper within 24 h. Clioquinol (50 µM) induced the oxidation of the copper chaperone antioxidant 1 (ATOX1), suggesting its inactivation and inhibition of copper transport. The secretion of dopamine-β-hydroxylase (DBH) and lysyl oxidase, both of which are copper-dependent enzymes, was altered by clioquinol (20–50 µM). Noradrenaline levels were reduced by clioquinol (20–50 µM). Disruption of the ATOX1 gene suppressed the secretion of DBH. This study suggested that the disturbance of cellular copper transport by the inactivation of ATOX1 is one of the mechanisms involved in clioquinol-induced neurotoxicity in SMON. More... »

PAGES

135-148

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00204-020-02894-0

DOI

http://dx.doi.org/10.1007/s00204-020-02894-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131544338

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33034664


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