Skin sensitization testing needs and data uses by US regulatory and research agencies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Judy Strickland, Amber B. Daniel, David Allen, Cecilia Aguila, Surender Ahir, Simona Bancos, Evisabel Craig, Dori Germolec, Chandramallika Ghosh, Naomi L. Hudson, Abigail Jacobs, David M. Lehmann, Joanna Matheson, Emily N. Reinke, Nakissa Sadrieh, Stanislav Vukmanovic, Nicole Kleinstreuer

ABSTRACT

United States regulatory and research agencies may rely upon skin sensitization test data to assess the sensitization hazards associated with dermal exposure to chemicals and products. These data are evaluated to ensure that such substances will not cause unreasonable adverse effects to human health when used appropriately. The US Consumer Product Safety Commission, the US Environmental Protection Agency, the US Food and Drug Administration, the Occupational Safety and Health Administration, the National Institute for Occupational Safety and Health, and the US Department of Defense are member agencies of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). ICCVAM seeks to identify opportunities for the use of non-animal replacements to satisfy these testing needs and requirements. This review identifies the standards, test guidelines, or guidance documents that are applicable to satisfy each of these agency's needs; the current use of animal testing and flexibility for using alternative methodologies; information needed from alternative tests to fulfill the needs for skin sensitization data; and whether data from non-animal alternative approaches are accepted by these US federal agencies. More... »

PAGES

1-19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00204-018-2341-6

DOI

http://dx.doi.org/10.1007/s00204-018-2341-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107923924

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30377734


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