Humoral and cellular immune response in Wistar Han RCC rats fed two genetically modified maize MON810 varieties for 90 days ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05-31

AUTHORS

Jana Tulinská, Karine Adel-Patient, Hervé Bernard, Aurélia Líšková, Miroslava Kuricová, Silvia Ilavská, Mira Horváthová, Anton Kebis, Eva Rollerová, Júlia Babincová, Radka Aláčová, Jean-Michel Wal, Kerstin Schmidt, Jörg Schmidtke, Paul Schmidt, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Pablo Steinberg

ABSTRACT

The genetically modified maize event MON810 expresses a Bacillus thuringiensis-derived gene, which encodes the insecticidal protein Cry1Ab to control some lepidopteran insect pests such as the European corn borer. It has been claimed that the immune system may be affected following the oral/intragastric administration of the MON810 maize in various different animal species. In the frame of the EU-funded project GRACE, two 90-day feeding trials, the so-called studies D and E, were performed to analyze the humoral and cellular immune responses of male and female Wistar Han RCC rats fed the MON810 maize. A MON810 maize variety of Monsanto was used in the study D and a MON810 maize variety of Pioneer Hi-Bred was used in the study E. The total as well as the maize protein- and Cry1Ab-serum-specific IgG, IgM, IgA and IgE levels, the proliferative activity of the lymphocytes, the phagocytic activity of the granulocytes and monocytes, the respiratory burst of the phagocytes, a phenotypic analysis of spleen, thymus and lymph node cells as well as the in vitro production of cytokines by spleen cells were analyzed. No specific Cry1Ab immune response was observed in MON810 rats, and anti-maize protein antibody responses were similar in MON810 and control rats. Single parameters were sporadically altered in rats fed the MON810 maize when compared to control rats, but these alterations are considered to be of no immunotoxicological significance. More... »

PAGES

2385-2399

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00204-018-2230-z

DOI

http://dx.doi.org/10.1007/s00204-018-2230-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104330369

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29855658


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362 schema:name Institute for Biosafety in Plant Biotechnology, Julius Kühn-Institut, Federal Research Centre for Cultivated Plants, Erwin-Baur-Str. 27, 06484 Quedlinburg, Germany
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365 schema:name Service de Pharmacologie et d’Immunoanalyse, Laboratoire d’Immuno-Allergie Alimentaire (LIAA), INRA, CEA, Université Paris Saclay, DRF/Institut Joliot/SPI-Bat 136, CEA de Saclay, 91191 Gif sur Yvette Cedex, France
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367 grid-institutes:grid.72925.3b schema:alternateName Present Address: Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Haid-und-Neu-Str. 9, 76131 Karlsruhe, Germany
368 schema:name Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany
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371 grid-institutes:grid.9464.f schema:alternateName Present Address: Biostatistics (340c), University of Hohenheim, Fruwirthstr. 23, 70599 Stuttgart, Germany
372 schema:name BioMath GmbH, Friedrich-Barnewitz-Str. 8, 18119 Rostock-Warnemünde, Germany
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375 grid-institutes:grid.9982.a schema:alternateName Faculty of Medicine, Slovak Medical University, Limbová 12, 83303 Bratislava, Slovakia
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