Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10-02

AUTHORS

Dagmar Zeljenková, Katarína Ambrušová, Mária Bartušová, Anton Kebis, Jevgenij Kovrižnych, Zora Krivošíková, Miroslava Kuricová, Aurélia Líšková, Eva Rollerová, Viera Spustová, Elena Szabová, Jana Tulinská, Soňa Wimmerová, Mikuláš Levkut, Viera Révajová, Zuzana Ševčíková, Kerstin Schmidt, Jörg Schmidtke, Jose Luis La Paz, Maria Corujo, Maria Pla, Gijs A. Kleter, Esther J. Kok, Jutta Sharbati, Carlos Hanisch, Ralf Einspanier, Karine Adel-Patient, Jean-Michel Wal, Armin Spök, Annette Pöting, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Pablo Steinberg

ABSTRACT

The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu ) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event. More... »

PAGES

2289-2314

References to SciGraph publications

Journal

TITLE

Archives of Toxicology

ISSUE

12

VOLUME

88

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00204-014-1374-8

DOI

http://dx.doi.org/10.1007/s00204-014-1374-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023620042

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25270621


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